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Plasma and tissue concentrations of α-tocopherol during vitamin E depletion in sheep

Published online by Cambridge University Press:  09 March 2007

J. M. Fry ,
G. M. Smith ,
M. C Mcgrath ,
E. J. Speijers  and
J. G. Allen
J. M. Fry
Affiliation:
Animal Health Division, Western Australian Department of Agriculture, Baron Hay-court, South Perth, Western Australia 6151, Australia
G. M. Smith
Affiliation:
Plant Industries Division, Western Australian Department of Agriculture, Baron Hay-court, South Perth, Western Australia 6151, Australia
M. C Mcgrath
Affiliation:
Animal Health Division, Western Australian Department of Agriculture, Baron Hay-court, South Perth, Western Australia 6151, Australia
E. J. Speijers
Affiliation:
Plant Industries Division, Western Australian Department of Agriculture, Baron Hay-court, South Perth, Western Australia 6151, Australia
J. G. Allen
Affiliation:
Animal Health Division, Western Australian Department of Agriculture, Baron Hay-court, South Perth, Western Australia 6151, Australia
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Abstract

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To determine the relationship between plasma and tissue α-tocopherol concentrations during vitamin E depletion, weaned lambs were placed on a vitamin E-deficient diet for 0, 1, 2, 4, 8 and 12 weeks. α-Tocopherol was measured in plasma, erythrocytes, liver, adrenal, adipose tissue, three different skeletal muscles and heart muscle. The α-tocopherol concentration in plasma fell at the same rate as the α-tocopherol concentration in skeletal muscles, heart muscle, adrenal and adipose tissue. The α-tocopherol concentration in liver and erythrocytes fell at a faster rate than that of plasma and all muscle tissues. There were significant correlations between α-tocopherol concentration in plasma and α-tocopherol concentrations in all the tissues measured. Different skeletal muscles had significantly different concentrations of α-tocopherol which may relate to their differing susceptibility to nutritional myopathy. The increase in malondialdehyde in oxidatively-stressed muscle tissue and the correlation with α-tocopherol concentration in most muscle tissues indicated that the muscles had reduced antioxidant capacity in vitro as a result of vitamin E depletion. It was concluded that during vitamin E depletion in sheep α-tocopherol concentration in plasma was a good index of vitamin E status under the experimental conditions employed.

Keywords

α-TocopherolVitamin ENutritional myopathySheep
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 225 - 232
Copyright
Copyright © The Nutrition Society 1993

References

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