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Plasma 65Zn Kinetics in the rat

Published online by Cambridge University Press:  09 March 2007

N. M. Lowe ,
I. Bremner  and
M. J. Jackson
N. M. Lowe
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
I. Bremner
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
M. J. Jackson
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
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Abstract

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The amount of 65Zn in the plasma of rats after intravenous injection was found to decline following closely two-compartment kinetics over a period of 90 min. Comparative analysis of the amount of 65Zn present in the two kinetic pools at various time-intervals post-injection with the actual physiological location of the 65Zn, revealed that the initial pool (Qa) is primarily the blood plasma, while the second pool (Qb) is primarily within the liver. The plasma Zn concentration and Qa were both found to fall reproducibly during Zn depletion, whereas Qa and Qb increased following injection of Escherichia coli endotoxin in contrast to the decline in plasma Zn concentration. Further investigation of the nature of Qb indicates that it represents in part a metabolic pool within the liver which varies substantially in response to Zn status in a manner similar to metallothionein.

Keywords

ZincRat
Type
Trace Element Metabolism
Information
British Journal of Nutrition , Volume 65 , Issue 3 , May 1991 , pp. 445 - 455
Copyright
Copyright © The Nutrition Society 1991

References

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