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A pilot study of vitamin B12 in the treatment of tiredness

Published online by Cambridge University Press:  09 March 2007

F. R. Ellis  and
S. Nasser
F. R. Ellis
Affiliation:
Department of Pathology, Kindston and Long Grove Group Hospitals, 37 Coombe Road, Kingston upon Thames, Surrey TK2 7BD
S. Nasser
Affiliation:
Department of Pathology, Kindston and Long Grove Group Hospitals, 37 Coombe Road, Kingston upon Thames, Surrey TK2 7BD
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Abstract

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1. Twenty-eight subjects complaining of tiredness completed a double-blind cross-over trial of injections of hydroxocobalamin (5 mg twice weekly for 2 weeks) followed by a rest period of 2 weeks and then a similar course of matching placebo injections. Symptoms were assessed by a daily self-rating method and included appetite, mood, energy, sleep and general feeling of well-being.

2. Those subjects who received the placebo in the first 2-week period showed a favourable response to hydroxocobalamin in the second period in all measurements made. The response achieved statistical significance (P = 0·006) in respect of general well-being; ‘happiness’ achieved a value of P = 0·032. Subjects who received hydroxocobalamin in the first period showed no difference between responses to active and placebo treatments, which suggests that the effects of the vitamin may persist for a period of at least 4 weeks.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 30 , Issue 2 , September 1973 , pp. 277 - 283
Copyright
Copyright © The Nutrition Society 1973

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