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Phyto-oestrogen intake and plasma concentrations in South Asian and native British women resident in England

Published online by Cambridge University Press:  08 March 2007

Dee Bhakta ,
Craig D. Higgins ,
Leena Sevak ,
Punam Mangtani ,
Herman Adlercreutz ,
Anthony J. McMichael  and
Isabel dos Santos Silva
Dee Bhakta
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
Craig D. Higgins
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
Leena Sevak
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
Punam Mangtani
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
Herman Adlercreutz
Affiliation:
Institute for Preventative MedicineNutrition and CancerFolkhälsan ResearchCenter and Division of Clinical Chemistry University of HelsinkiHelsinkiFinland
Anthony J. McMichael
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
Isabel dos Santos Silva*
Affiliation:
Department of Epidemiology and Population HealthLondon School of Hygiene and Tropical MedicineKeppel StreetLondon WC1E 7HTUK
*
*Corresponding author: author: Dr Isabel dos Santos Silva, fax +44 (0)20 7580 6897, email [email protected]
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Abstract

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Phyto-oestrogens, naturally occurring hormone-like chemicals in plant food, may play a protective role against hormone-related chronic diseases. South Asian migrants in the UK have a lower incidence of hormone-related cancer than their hosts but the extent to which this difference may be due to phytoestrogen intake is not known. The aim was to compare habitual phytoestrogen intake in first-generation South Asian migrant women and native British women. South Asian (n 221) and native British women (n 50) were recruited from general practitioner lists and were asked to provide monthly 24h recalls for a period of 1 year. An enhanced phytoestrogen database was compiled using data from a literature search and unpublished data. A sub-sample of South Asian women (n 100) and the native British women (n 40) also provided blood samples every 3 months during the 1-year period. The median daily intakes (μg/d) of isoflavones (184·2 v. 333·9) and lignans (110·8 v. 148·8) were significantly lower in South Asians than in the native British (P<0·001, P=0·04 respectively).There were no significant differences in mean plasma isoflavone levels (nmol/l) but plasma enterolactone was significantly lower in the South Asians (13·9 (sd17·5) v. 28·5 (SD23·3),P<0·001). The main sources of phytoestrogens were bread and vegetables in both ethnic groups. Habitual phytoestrogen intake in South Asian and native British women was below 1mg/d and was higher in the native British diet. The present study does not support the hypothesis that differences in phytoestrogen intake, or in circulating levels, could explain differences in hormone-related cancer risks between these two populations.

Keywords

Phytoestrogen24-h recallSouth Asian dietIsoflavonesLignansGenisteinDaidzeinEnterolactone
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 6 , June 2006 , pp. 1150 - 1158
Copyright
Copyright © The Nutrition Society 2006

References

Adlercreutz, H & Mazur, WPhyto-estrogens and Western diseases. Ann Med 1997 29 95–120CrossRefGoogle ScholarPubMed
Arai, Y, Uehara, M, Sato, Yet al. Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol 2000 10 127–135Google Scholar
Axelson, M, Sjövall, J, Gustafsson, BE & Setchell, KOrigin of lignan in mammals and identification of a precursor from plants. Nature 1982 298 659–660CrossRefGoogle ScholarPubMed
Bhakta, D Comparison of dietary patterns of South Asian migrants and native British women, with a particular focus on the intake and biological levels of phytoestrogens. PhD Thesis University of London 2003Google Scholar
Bhakta, D, dos Santos, Silva I, Higgins, Cet al. A semiquantitative food frequency questionnaire is a valid indicator of phytoestrogens by South Asian women in the UK relative to multiple 24-h dietary recalls and multiple plasma samples. J Nutr 2005 135 116–123CrossRefGoogle ScholarPubMed
Bingham, SA, Liggins, J, Bluck, L & Coward, LIsoflavone Concentrations in Foods: The Biological Effects of Phytoestrogens. LondonMinistry of Agriculture, Fisheries and Foods 1998Google Scholar
de Kleijn, MJJ, van der Schouw, YT, Wilson, PWFet al. Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham Study. J Nutr 2001 131 1826–1832CrossRefGoogle ScholarPubMed
Department of Health The Health Survey of Minority Ethnic Groups, 1999. LondonThe Stationery Office 2001Google Scholar
dos Santos, Silva I, Mangtani, P, McCormack, VA, Bhakta, D, McMichael, AJ & Sevak, LPhytoestrogen intake and breast cancer risk in South Asian women in England: findings from a population-based case-control study. Cancer Causes Control 2004 15 805–818Google Scholar
dos Santos, Silva I, Mangtani, P, McCormack, V, Bhakta, D, Sevak, L & McMichael, AJLifelong vegetarianism and risk of breast cancer: a population-based case-control study among South Asian migrant women living in England. Int J Cancer 2002 99 238–244CrossRefGoogle Scholar
Erdman, J, Stillman, R & Boileau, RProvocative relationship between soy and bone maintenance. Am J Clin Nutr 2000 72 679–680CrossRefGoogle Scholar
Goldberg, GR, Black, AE, Jebb, SAet al. Critical evaluation of energy intake data using fundamental principles of energy physiology 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr 1991 45 569–581Google Scholar
Gooderham, M, Adlercreutz, H, Ojala, S, Wähälä, K & Holub, BA soy protein isolate rich in genistein and daidzein and its effect on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. J Nutr 1996 126 2000–2006Google Scholar
Horn-Ross, P, Barnes, S, Kirk, M, Coward, L, Parsonnett, J & Hiatt, RUrinary phytoestrogens levels in young women from a multi-ethnic population. Cancer Epidemiol Biomarkers Prev 1997 6 339–345Google Scholar
Horn-Ross, PL, Hogatt, KJ & West, DWet al. Recent diet and breast cancer risk: the California Teachers Study (USA). Cancer Causes Control 2002 13 407–415CrossRefGoogle ScholarPubMed
Horn-Ross, P, Lee, M, John, E & Koo, JSources of phytoestrogens exposure among non-Asian women in California, USA. Cancer Causes Control 2000 11 299–302CrossRefGoogle ScholarPubMed
Hutchins, A, Martini, M, Olson, B, Thomas, W & Slavin, JFlaxseed influences urinary lignan excretion in a dose-dependent manner in post-menopausal women. Cancer Epidemiol Biomarkers Prev 2000 9 1113–1118Google Scholar
Hutchins, A, Slavin, J & Lampe, JUrinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Dietet Assoc 1995 95 545–551CrossRefGoogle ScholarPubMed
Ingram, D, Sanders, K, Kolybaba, M & Lopez, DCasecontrol study of phytoestrogens and breast cancer. Lancet 1997 350 990–994CrossRefGoogle ScholarPubMed
Jacobs, E, Kulling, S & Metzler, MNovel metabolites of the mammalian lignans enterolactone and enterodiol in human urine. J Steroid Biochem Mol Bio 1999 68 211–218CrossRefGoogle ScholarPubMed
Judd, PA, Kassam-Khamis, T & Thomas, JEThe Composition and Nutrient Content of Foods Commonly Consumed by South Asians in the UK. LondonThe Aga Khan Health Board for the United Kingdom 2000Google Scholar
Kamath, S, Murillo, G & Chatterton, RTet al. Breast cancer risk factors in two distinct ethnic groups: Indian and Pakistani vs American premenopausal women.. Nutr Cancer 1999 35 16–26CrossRefGoogle ScholarPubMed
Keinan-Boker, L, van Der Schow, YT, Grobbee, DE & Peeters, PHMDietary phytoestrogens and breast cancer risk. Am J Clin Nutr 2004 79 282–288CrossRefGoogle ScholarPubMed
Key, TJ, Sharp, GB, Appleby, Pet al. Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. Br J Cancer 1999 81 1248–1256Google Scholar
Kilkkinen, A, Pietinen, P, Klaukka, T, Virtamo, J, Korhornen, P & Adlercreutz, HUse of oral antimicrobials decreases plasma enterolactone concentration. Am J Epidemiol 2002 155 472–477CrossRefGoogle Scholar
Kilkkinen, A, Stumpf, K, Pietinen, M, Valsta, L, Tapanainen, H & Adlercreutz, HDeterminants of serum enterolactone concentration. Am J Clin Nutr 2001 73 1094–1100Google Scholar
Maskarinec, G, Singh, S, Meng, L & Franke, ADietary soy intake and urinary isoflavone excretion among women from a multiethnic population. Cancer Epidemiol Biomarkers Prev 1998 7 613–619Google ScholarPubMed
Mazur, WPhytoestrogen content in foods. In Balliere's Clinical Endocrinology and Metabolism, Phytoestrogens, Adlercreutz, HLondonHarcourt Brace 1998 12:4 729–742Google Scholar
Mazur, W, Duke, J, Wähälä, K, Rasku, S & Adlercreutz, HIso-flavonoids and lignans in legumes: nutritional and health aspects in humans. Nutr Biochem 1998 9 1–8Google Scholar
McCormack, VA, Mangtani, P, Bhakta, Det al. Heterogeneity of breast cancer risk within the South Asian female population in England: a population-based case-control study of first-generation migrants. Br J Cancer 2004 99 160–166CrossRefGoogle Scholar
McKeigue, P, Adelstein, A, Marmot, Met al. Diet and faecal steroid profile in a South Asian population with a low coloncancer rate. Am J Clin Nutr 1989 50 151–154Google Scholar
Milder, I, Feskens, J, Arts, I, Bas Bueno de Mesquita, H, Hollman, P & Kromhout, DIntake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol and pinoresinol in Dutch men and women. J Nutr 2005 135 1202–1207Google Scholar
Nagata, C, Takatsuka, N, Kawakami, N & Shimizu, HSoy product intake and hot flashes in Japanese women: results from a community-based prospective study. Am J Epidemiol 2001 153 790–793Google Scholar
Nanchanal, K, Mangtani, P, Alston, Met al. Development and validation of a computerised South Asian Names and Group Recognition (SANGRA) for use in British health-related studies. J Publ Health Med 2001 23 278–285CrossRefGoogle Scholar
Nesbitt, P, Lam, Y & Thompson, LHuman metabolism of mammalian precursors in raw and processed flaxseed. Am J Clin Nutr 1999 6 549–555Google Scholar
Office of Population and Census Survey UK. Birth Statistics, 1991. Series FM1 no. 20. LondonHMSO 1993Google Scholar
Peach, CEthnicity in the 1991 Census. The Ethnic Minority Populations of Great Britain LondonHMSO 1996 2Google Scholar
Pietinen, P, Stumpf, K, Männistö, S, Kataja, V, Uusitupa, M & Adlercreutz, HPlasma enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 2001 10 339–344Google Scholar
Rowland, I, Wiseman, H, Sanders, T, Adlercreutz, H & Bowey, EInter-individual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000 36 27–32Google Scholar
Shu, G, Jin, F, Dai, Qet al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2001 110 483–488Google Scholar
Smith, Z, Knight, T, Sahota, P & Baker, MDietary patterns in Asian and Caucasian men in Bradford: differences and implications for nutrition education. J Hum Nutr Diet 1993 6 323–333Google Scholar
Stumpf, K, Uehara, M, Nurmi, T & Adlercreutz, HChanges in time-resolved fluoroimmunoassay of plasma enterolactone. Anal Biochem 2000 284 153–157CrossRefGoogle ScholarPubMed
van Erp-Baart, MJ, Brants, HAM, Kiely, Met al. Isoflavone intake in four different European countries: the VENUS approach. Br J Nutr 2003 89S S25–S30CrossRefGoogle ScholarPubMed
Vanharanta, M, Voutilainen, S, Lakka, TA, van der Lee, , Adlercreutz, H, Salonen, JTRisk of acute coronary events according to plasma concentrations of enterolactone: a prospective populationbased case-control study. Lancet 1999 354 2112–2115Google Scholar
Verkasalo, PK, Appleby, PN, Allen, NE, Davey, G, Adlercreutz, H & Key, TJSoya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women, Oxford arm of the European Prospective Investigation into Cancer. Br J Nutr 2001 86 415–421Google Scholar
Wang, GJ, Läpcik, O, Hampl, Ret al. Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 2000 65 339–348Google Scholar
Winter, H, Cheng, KK, Cummins, C, Maric, R, Silcocks, P & Varghese, CCancer incidence in the South Asian population in England, 1990–92. Br J Cancer 1999 79 645–654CrossRefGoogle ScholarPubMed
Yamomoto, S, Sobue, T, Kobayashi, Met al. Validity and reproducibility of a self-administered food frequency questionnaire to assess isoflavone intake in Japanese populations in comparison with dietary records and blood and urine isoflavones. J Nutr 2001 131 2741–2747CrossRefGoogle Scholar
Yamomoto, S, Sobue, T, Kobayashi, M, Sasaki, S & Tsugane, SSoy, isoflavones and breast cancer risk in Japan. J Natl Cancer Inst 2003 95 906–913Google Scholar
Zeleniuch-Jacquotte, A, Adlercreutz, H, Akhmedkhanov, A & Toniolo, PReliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two year period. Cancer Epidemiol Biomarkers Prev 1998 7 885–889Google Scholar