Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-22T08:02:49.492Z Has data issue: false hasContentIssue false
  • English
  • Français

The physical state of a meal affects hormone release and postprandial thermogenesis

Published online by Cambridge University Press:  09 March 2007

Maddalena Peracchi ,
Alessandra Santangelo ,
Dario Conte ,
Mirella Fraquelli ,
Rosalia Tagliabue ,
Carlotta Gebbia  and
Marisa Porrini
Maddalena Peracchi*
Affiliation:
Department of Gastroenterology Institute of Medical Science, University of Milan, Ospedale Maggiore-IRCCS, via F. Sforza 35, 20122 Milan, Italy
Alessandra Santangelo
Affiliation:
Department of Food Science and Technology Nutrition Section, University of Milan, via Celoria 2, 20133 Milan, Italy
Dario Conte
Affiliation:
Department of Gastroenterology Institute of Medical Science, University of Milan, Ospedale Maggiore-IRCCS, via F. Sforza 35, 20122 Milan, Italy
Mirella Fraquelli
Affiliation:
Department of Gastroenterology Institute of Medical Science, University of Milan, Ospedale Maggiore-IRCCS, via F. Sforza 35, 20122 Milan, Italy
Rosalia Tagliabue
Affiliation:
Department of Gastroenterology Institute of Medical Science, University of Milan, Ospedale Maggiore-IRCCS, via F. Sforza 35, 20122 Milan, Italy
Carlotta Gebbia
Affiliation:
Department of Gastroenterology Institute of Medical Science, University of Milan, Ospedale Maggiore-IRCCS, via F. Sforza 35, 20122 Milan, Italy
Marisa Porrini
Affiliation:
Department of Food Science and Technology Nutrition Section, University of Milan, via Celoria 2, 20133 Milan, Italy
*
*Corresponding author: Dr Maddalena Peracchi, fax +39 02 55012111, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

There is evidence that food consistency may influence postprandial physiological responses. Recently we found that homogenization of a vegetable-rich meal significantly delayed the gastric emptying rate and was more satiating than the same meal in solid–liquid form. In this present study we investigated whether homogenization also influences endocrine and metabolic responses to the meal. Eight healthy men, aged 21–28 (mean 24·5) years, were given the meal (cooked vegetables 250 g, cheese 35 g, croutons 50 g and olive oil 25 g, with water 300 ml; total energy 2·6 MJ) in both solid–liquid (SM) and homogenized (HM) form, in random order, at 1-week intervals. Variables assayed were plasma glucose, insulin and glucose-dependent insulinotropic peptide (GIP) levels for 2 h and diet-induced thermogenesis (DIT) for 5 h. Plasma glucose pattern was similar after both meals. However, HM induced significantly greater insulin, GIP and DIT responses than SM. Mean integrated areas under the curves (AUC) were 1·7 (SEM 0·38) V. 1·2 (sem 0·33) U/l per 120 min (P = 0·005) for insulin, 19·9 (sem 2·44) v. 16 (sem 1·92) nmol/l per 120 min (P = 0·042) for GIP, and 237·7 (sem 16·32) v. 126·4 (sem 23·48) kJ/300 min (P = 0·0029) for DIT respectively. Differences between GIP-AUC after HM and SM correlated significantly with differences between insulin-AUC after HM and SM (r2 0·62, P = 0·021). These findings demonstrate that homogenization of a meal results in a coordinated series of changes of physiological gastroentero–pancreatic functions and confirm that the physical state of the meal plays an important role in modulating endocrine and metabolic responses to food.

Keywords

Food consistencyGlucose-dependent insulinotropic peptideInsulinDiet-induced thermogenesis
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue 6 , June 2000 , pp. 623 - 628
Copyright
Copyright © The Nutrition Society 2000

References

Andersen, DKElahi, DBrown, JCTobin, JD and Andres, R (1978) Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels Journal of Clinical Investigation 62, 152–161.CrossRefGoogle ScholarPubMed
Anderson, JW and Lin Chen, WJ (1979) Plant fiber. Carbohydrate and lipid metabolism American Journal of Clinical Nutrition 32, 346–363.CrossRefGoogle ScholarPubMed
Beck, BVillaume, CChayvialle, JAGariot, PUlmer, M, Desalme, A and Debry, G (1984) Influence of caloric intake on gastric inhibitory polypeptide, VIP and gastrin release in man Peptides 5, 403–406.CrossRefGoogle ScholarPubMed
Bjorck, I (1996) Starch: nutritional aspects. In Carbohydrates in Food, pp. 505–553 [Eliasson, AC, editor]. New York, NY: Marcel Dekker Inc.Google Scholar
Calles-Escandon, J and Robbins, DC (1987) Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose Diabetes 36, 1167–1172.CrossRefGoogle ScholarPubMed
Collier, GMcLean, A and O'Dea, K (1984) Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates Diabetologia 26, 50–54.CrossRefGoogle ScholarPubMed
Estrich, DRavnik, ASchlierf, G, Fukayama, G and Kinsell, L (1967) Effects of co-ingestion of fat and protein upon carbohydrate-induced hyperglycemia Diabetes 16, 232–237.CrossRefGoogle ScholarPubMed
Fehmann, HCGoke, R and Goke, B(1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide Endocrine Reviews 16, 390–410.CrossRefGoogle ScholarPubMed
Flatt, PRBailey, CJKwasowski, PPage, T and Marks, V (1984) Plasma immunoreactive gastric inhibitory polypeptide in obese hyperglycemic (ob/ob) mice Journal of Endocrinology 101, 249–256.CrossRefGoogle Scholar
Fried, MSchwizer, WBeglinger, C, Keller, UJansen, JB and Lamers, CB (1991) Physiological role of cholecystokinin on postprandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor antagonist loxiglumide Diabetologia 34, 721–726.CrossRefGoogle ScholarPubMed
Gulliford, MCBicknell, EJ and Scarpello, JH (1989) Differential effect of protein and fat ingestion on blood glucose responses to high- and low-glycemic-index carbohydrates in non insulin-dependent diabetic subjects American Journal of Clinical Nutrition 50, 773–777.CrossRefGoogle Scholar
Gustafsson, KAsp, NGHagander, B and Nyman, M (1995) Satiety effects of spinach in mixed meals: comparison with other vegetables International Journal of Food Sciences and Nutrition 46, 327–334.CrossRefGoogle ScholarPubMed
Habas, ME and Macdonald, IA (1998) Metabolic and cardiovascular responses to liquid and solid test meals British Journal of Nutrition 79, 241–247.CrossRefGoogle ScholarPubMed
Holt, SHABrand Miller, JC and Petocz, P (1996) Interrelationships among postprandial satiety, glucose and insulin responses and changes in subsequent food intake European Journal of Clinical Nutrition 50, 788–797.Google ScholarPubMed
Holt, SHA and Miller, B (1994) Particle size, satiety and the glycaemic response European Journal of Clinical Nutrition 48, 496–502.Google ScholarPubMed
Joannic, JLAuboiron, SRaison, J, Basdevant, ABornet, F and Guy-Grand, B (1997) How the degree of unsaturation of dietary fatty acids influences the glucose and insulin responses to different carbohydrates in mixed meals American Journal of Clinical Nutrition 65, 1427–1433.CrossRefGoogle ScholarPubMed
Landsberg, L and Young, JB (1983) The role of the sympathetic nervous system and catecholamines in the regulation of energy metabolism American Journal of Clinical Nutrition 38, 1018–1024.CrossRefGoogle ScholarPubMed
Lavin, JHWittert, GAAndrews, JYeap, B, Wishart, JMMorris, HA, Morley, JEHorowitz, M and Read, NW (1998) Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate American Journal of Clinical Nutrition 68, 591–598.CrossRefGoogle ScholarPubMed
LeBlanc, J, Diamond, P and Nadeau, A (1991) Thermogenic and hormonal responses to palatable protein and carbohydrate rich food Hormone and Metabolic Research 23, 336–340.CrossRefGoogle ScholarPubMed
LeBlanc, J, Soucy, J and Nadeau, A (1996) Early insulin and glucagon responses to different food items Hormone and Metabolic Research 28, 276–279.CrossRefGoogle ScholarPubMed
Morgan, LMTredger, JAWright, J and Marks, V (1990) The effect of soluble- and insoluble-fibre supplementation on postprandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects British Journal of Nutrition 64, 103–110.CrossRefGoogle ScholarPubMed
Naslund, E, Gutniak, MSkogar, S, Rossner, S and Hellstrom, PM (1998) Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men American Journal of Clinical Nutrition 68, 525–530.CrossRefGoogle ScholarPubMed
Ørskov, C, Wettergren, A and Holst, JJ (1996) Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day Scandinavian Journal of Gastroenterology 31, 665–670.CrossRefGoogle ScholarPubMed
Peracchi, MBasilisco, GTagliabue, R, Terrani, CLocati, A, Bianchi, PA and Velio, P (1999) Postprandial gut peptide plasma levels in women with idiopathic slow-transit constipation Scandinavian Journal of Gastroenterology 34, 25–28.Google ScholarPubMed
Raben, AAndersen, KKarberg, MAHolst, JJ and Astrup, A (1997) Acetylation of or β-cyclodextrin addition to potato starch: beneficial effect on glucose metabolism and appetite sensations American Journal of Clinical Nutrition 66, 304–314.CrossRefGoogle ScholarPubMed
Raben, AHolst, JJChristensen, NJ and Astrup, A (1996) Determinants of post-prandial appetite sensations: macronutrient intake and glucose metabolism International Journal of Obesity 20, 161–169.Google Scholar
Rothwell, NJ (1992) Hypothalamus and thermogenesis. In Energy Metabolism: Tissue Determinants and Cellular Corollaries, pp. 229–245 [Kinney, JM and Tucker, HN, editors]. New York, NY: Raven Press Ltd.Google Scholar
Santangelo, APeracchi, MConte, D, Fraquelli, M and Porrini, M (1998) Physical state of meal affects gastric emptying, cholecystokinin release and satiety British Journal of Nutrition 80, 521–527.CrossRefGoogle ScholarPubMed
Sarson, DLHayter, RC and Bloom, SR (1982) The pharmacokinetics of porcine glucose-dependent insulinotropic polypeptide (GIP) in man European Journal of Clinical Investigation 12, 457–461.CrossRefGoogle ScholarPubMed
Schirra, JKatschinski, MWeidmann, C, Schafer, T, Wank, UArnold, R and Goke, B (1996) Gastric emptying and release of incretin hormones after glucose ingestion in humans Journal of Clinical Investigation 97, 92–103.CrossRefGoogle ScholarPubMed
Teff, KLMattes, RD and Engelman, K (1991) Cephalic phase insulin release in normal weight males: verification and reliability American Journal of Physiology 261, E430–E436.Google ScholarPubMed
Torsdottir, IAlpsten, MAndersson, H and Einarsson, S (1989) Dietary guar gum effects on postprandial blood glucose, insulin and hydroxyproline in humans Journal of Nutrition 119, 1925–1931.CrossRefGoogle ScholarPubMed
Weir, JB, De, V (1949) New method for calculating metabolic rate with special to protein metabolism Journal of Physiology 109, 1–9.CrossRefGoogle ScholarPubMed
Wolever, TMS and Bolognesi, C (1996) Source and amount of carbohydrate affect postprandial glucose and insulin in normal subjects Journal of Nutrition 126, 2798–2806.Google ScholarPubMed
Wursch, P (1989) Starch in human nutrition World Review of Nutrition and Dietetics 60, 199–256.CrossRefGoogle ScholarPubMed