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Nutritional status of drug addicts undergoing detoxification: prevalence of malnutrition and influence of illicit drugs and lifestyle

Published online by Cambridge University Press:  09 March 2007

S. K. Nazrul Islam ,
Kazi Jahangir Hossain ,
Afsaruddin Ahmed  and
Monira Ahsan
S. K. Nazrul Islam*
Affiliation:
Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh
Kazi Jahangir Hossain
Affiliation:
Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh
Afsaruddin Ahmed
Affiliation:
Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh
Monira Ahsan
Affiliation:
Department of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
*
*Corresponding author:Dr S. K. Nazrul Islam, fax +880 2 8615583, email [email protected]
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Abstract

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The aim of the present study was to investigate the nutritional status of drug addicts, the prevalence of malnutrition among them and the influence of their drug habit and lifestyle factors on their nutritional indices. The study was conducted among 253 male drug addicts, who sought detoxification at the Central Drug Addiction Treatment Hospital, Dhaka, during the period of June 1998–July 1999. One hundred age-, height- and socioeconomic-matched non-addicted healthy men were recruited by convenience as cohort controls. Results showed that the drug addicts had significantly (P<0·001) lowered BMI, haemoglobin, and serum total protein and albumin levels. Clinical signs of nutrient deficiency were diagnosed in about 74 % of drug addicts. The BMI, biochemical values and nutrient deficiency signs indicated that more than 60 % of drug addicts were suffering from multiple malnutrition. One-way ANOVA demonstrated a significant (P<0·05) negative correlation between drug habit, sexually transmitted diseases and selected nutritional indices, and a positive correlation between education, income and the nutritional indices. A series of multiple regression analyses revealed that education, income and age showed significantly predicted BMI and biochemical indices, and the group (non-drug addicts or drug addicts) had a significant negative effect on these parameters in favour of controls.

Keywords

Drug addictionNutritional statusDrug habitLifestyle
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue 5 , November 2002 , pp. 507 - 513
Copyright
Copyright © The Nutrition Society 2002

References

Allard, JP, Aghdassi, E, Chau, J, Salit, I & Walmsley, S (1998) Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection.American Journal of Clinical Nutrition 67, 143–147.CrossRefGoogle ScholarPubMed
Baum, MK, Shor-Posner, G & Campa, A (2000) Zinc status in human immunodeficiency virus infection. Journal of Nutrition 130, 1421S–1423S.CrossRefGoogle ScholarPubMed
Baum, MK, Shor-Posner, G, Lu, Y, Rosner, B, Sauberlich, HE, Fletcher, MA, Szapocznik, J, Eisdorfer, C, Buring, JE & Hennekens, CH (1995) Micronutrients and HIV-1 disease progression. AIDS 9, 1051–1056.CrossRefGoogle ScholarPubMed
Beatty, WW & Borrell, GK (2000) Forms of knowledge, cognitive impairment and drug abuse: a demonstration. Progress in Neuro-psychopharmacology and Biological Psychiatry 24, 17–22.CrossRefGoogle ScholarPubMed
Beisel, WR (1996) Nutrition in paediatric HIV infection: setting the research agenda Nutrition and immune function: Overview. Journal of Nutrition 126, Suppl., 2611S–2615S.CrossRefGoogle ScholarPubMed
Bluthenthal, R, Kral, A, Gee, L, Erringer, E & Edlin, E (2000) The effect of syringe exchange use on high risk IDUs: a cohort study. AIDS 14, 605–611.CrossRefGoogle Scholar
Booth, R, Kwiatkowski, C & Chitwood, D (2000) Sex-related HIV risk behaviors: differential risk among IDUs, crack smokers, and IDUs who smoke crack. Drug and Alcohol Dependence 58, 219–226.CrossRefGoogle Scholar
Brown, SM, Stimmel, BT & Taub, RN (1974) Immunologic dysfunction in heroin addicts. Archives of Internal Medicine 134, 1001–1006.CrossRefGoogle ScholarPubMed
Califano, JA Jr (1998) Substance abuse and addiction - the need to know. American Journal of Public Health 88, 9–11.CrossRefGoogle ScholarPubMed
Carr, DJJ & Serou, M (1995) Exogenous and endogenous opioids as biological response modifiers. Immunopharmacology 31, 59–71.CrossRefGoogle ScholarPubMed
Chandra, RK (1997) Nutrition and the immune system: an introduction. American Journal of Clinical Nutrition 66, 460S–463S.CrossRefGoogle ScholarPubMed
Chandra, RK (2001) Introduction and state of the art and science of nutrition and immunology (abstract). In The 17th International Congress of Nutrition, 27–31 August 2001, Vienna, Austria, p. 288 [Elmadfa, I and Konig, J, editors]. New York and London: Medical and Science Publishers.Google Scholar
Chlebowski, RT, Beall, G & Grosvenor, M (1993) Long term effects of early nutritional support with new enterotropic peptide-based formula vs standard enteral formula in HIV-infected patients: randomized prospective trial. Nutrition 9, 507–512.Google ScholarPubMed
Choi, KH, Xiwen, Z, Shuquan, Q, Yiee, K & Mandel, J (2000) HIV risk among patients attending sexually transmitted diseases clinic in China. AIDS and Behavior 4, 111–119.CrossRefGoogle Scholar
Courssons-Reed, ME, Dykstra, LA & Lystle, DT (1994) Pavlovian conditioning of morphine induced alterations of immune status. Brain Behavior Immunology 8, 204–217.Google Scholar
Finnegan, LP (1998) Perinatal Morbidity and Mortality in Substance Using Families: Effects and Intervention Strategies, pp. 1–21. Rockville, MD: NIDA, NIH, US Department of Health and Human Services.Google Scholar
Food and Agriculture Organization (1994) BMI as an indicator of CED. In Body Mass Index: A Measure of Chronic Energy Deficiency in Adults, pp. 17–20 [Shetty, PS and James, WPT, editors]. Rome: FAO.Google ScholarPubMed
Food and Agriculture Organization (1995) State of Nutrition in Bangladesh, pp. 1–66. Dhaka, Bangladesh: FAO.Google Scholar
Ganong, WF (1997) Review of Medical Physiology, 18th ed. pp. 481–508. New Jersey, USA: Prentice-Hall International, Inc.Google Scholar
Hegde, HR, Woodman, RC & Sankarn, K (1999) Nutrients as modulators of energy in AIDS. Journal of the Association of Physicians of India 47, 318–325.Google Scholar
Himmelgreen, DA, Perez-Escamilla, R, Segura-Millan, S, Romero-Daza, N, Tansescu, M & Sin, M (1998) A comparison of the nutritional status and food security of drug-using and non-drug-using Hispanic women in Hartford, Connecticut. American Journal of Physical Anthropology 107, 351–361.Google ScholarPubMed
International Development Research Centre and World Health Organization (1991) Designing and Conducting Health System Research Projects, vol. 2, part 1, pp. 195–218 [Varkevisser, CM, Pathmanathan, I and Brooconlee, A, editors]. Geneva: WHO.Google Scholar
Islam, SN, Hossain, KJ & Ahsan, M (2000) Sexual life style, drug habit and sociodemographic status of the drug addicts in Bangladesh. Public Health 114, 389–392.CrossRefGoogle Scholar
Islam, SN, Hossain, KJ & Ahsan, M (2001) Original communication: Serum vitamin E, C and A status of the drug addicts undergoing detoxification: influence of drug habit, sexual practice and life style factors. European Journal of Clinical Nutrition 55, 1022–1027.CrossRefGoogle Scholar
Johnson, A & Gerstein, DR (1998) Initiation of use of alcohol, cocaine, and other substances in US birth cohorts since 1919. American Journal of Public Health 88, 27–33.CrossRefGoogle ScholarPubMed
Kotler, DP (1998) Antioxidant therapy and HIV infection. American Journal of Clinical Nutrition 67, 7–9.CrossRefGoogle ScholarPubMed
Latham, MC (1997) Human Nutrition in the Developing World FAO, Food and Nutrition Series no 29, pp. 147–156. Rome: FAO.Google Scholar
Leklem, JE (1996) Vitamin B6. In Present Knowledge in Nutrition, 7th ed. pp. 174–183 [Ziegler, EE and Filer, LJ Jr, editors]. Washington, DC: ILSI Press.Google Scholar
Levine, M, Rumsey, S & Wang, Y (1996) Vitamin C. In Present Knowledge in Nutrition, 7th ed. pp. 146–159 [Ziegler, EE and Filer, LJ Jr, editors]. Washington, DC: ILSI Press.Google Scholar
Marangon, K, Herbeth, B, Lecomte, E, Paul-Dauohin, A, Grolier, P, Chancerelle, Y, Artur, Y & Siest, G (1998) Diet, antioxidant status, and smoking habits in French men. American Journal of Clinical Nutrition 67, 231–239.Google ScholarPubMed
Mason, S & Swash, M (1980) The mouth and throat. In Hutchison's Clinical Method, 17th ed. pp. 62–70 [Mason, S and Swash, M, editors]. London: ELBS, A Baillieze Tindall Publications.Google Scholar
Miyagi, AU, Chuang, T, Lam, KM, Kung, HF, Wang, JM, Osburn, BI & Chuang, RY (2000) Opioids suppress chemokine-mediated migration of monkey neutrophils and monocytes – an instant response. Immunopharmacology 47, 53–62.CrossRefGoogle ScholarPubMed
Mohs, ME, Watson, RR & Leonard-Green, T (1990) Nutritional effects of marijuana, heroin, cocaine and nicotine. Journal of the American Dietetic Association 90, 1261–1267.CrossRefGoogle ScholarPubMed
Morabia, A, Fabre, J, Chee, E, Zeger, S, Orsat, E & Robert, A (1989) Diet and opiate addiction: a quantitative assessment of the diet of non-institutionalized opiate addicts. British Journal of Addicts 84, 173–180.Google ScholarPubMed
Nagati, K (2001) Multiple approaches to micronutrient deficiency in developing countries (abstract). In The 17th International Congress of Nutrition, 27–31 August 2001, Vienna, Austria, p. 7 [Elmadfa, I and Konig, J, editors]. New York and London: Medical and Science Publishers.Google Scholar
Ogilvie, C & Evans, CC (1987) External manifestation of disease. In Chamberlain's Symptoms and Signs in Clinical Medicine, 11th ed. pp. 36–70 [Ogilvie, C and Evans, CC, editors]. Bristol: ELBS, IOP Publishing Ltd.Google Scholar
Rand, ML & Murray, RK (2000) Plasma proteins, immunoglobulins, and blood coagulation. In Harpar's Biochemistry, 25th ed. pp. 737–762 [Murray, RK, Granner, DK, Mayes, PA and Rodwell, VW, editors]. Stamford, CT: Appleton and Lange.Google Scholar
Rouveix, B (1992) Opiates and immune function: consequence on infectious disease with special reference to AIDS. Therapie 47, 503–512.Google ScholarPubMed
Scrimshaw, NS & SanGiovanni, JP (1997) Synergism of nutrition, infection, and immunity: an overview. American Journal of Clinical Nutrition 66, 464S–477S.CrossRefGoogle ScholarPubMed
Shearman, DJC (1996) Disease of the alimentary tract and pancreas. In Davidson's Principle and Practice of Medicine, 17th ed. pp. 405–482 [Edwards, CRW, Bouchier, D, Haslett, C and Chilverse, E, editors]. Edinburgh: ELBS, Churchill Livingstone.Google Scholar
Smith, DK, Gwinn, M, Selik, RM, Miller, KS, Dean-Gaitor, HD, Ma'at, PI, DeCock, KM & Gayle, HD (2000) HIV/AIDS among African Americans: progress or progression? AIDS 14, 1237–1248.CrossRefGoogle ScholarPubMed
Solis-Pereyra, B, Aattouri, N & Lemonnier, D (1997) Role of food in the stimulation of cytokine production. American Journal of Clinical Nutrition 66, 521S–525S.CrossRefGoogle ScholarPubMed
Thomas, PT, Bhargana, HN & House, RV (1995) Immunomodulatory effects of in vitro exposure to morphine and its metabolites.Pharmacology 50, 51–62.CrossRefGoogle ScholarPubMed
United Nations International Drug Control Programme (1997) Recent trends and development in cultivation, production, trafficking and consumption: an overview. In World Drug Report, pp. 16–43. New York: UNDCP, Oxford University Press.Google Scholar
Varela, P, Marcos, A, Ripoll, S, Santacruz, I & Requejo, AM (1997a) Effects of human immunodeficiency virus infection and detoxification time on anthropometric measurements and dietary intake of male drug addicts. American Journal of Clinical Nutrition 66, 509S–514S.CrossRefGoogle ScholarPubMed
Varela, P, Marcos, A, Santacruz, I, Ripoll, S & Requejo, AM (1997b) Human immunodeficiency virus infection and nutritional status in female drug addicts undergoing detoxification: anthropometric and immunologic assessments. American Journal of Clinical Nutrition 66, 504S–508S.CrossRefGoogle ScholarPubMed
Vasko, ME (1992) Drug abuse and dependence. In Goth's Medical Pharmacology, 13th ed. pp. 336–353 [Clerk, WO, Brater, DE and Johnson, AR, editors]. St. Louis, USA: Mosby Year Book.Google Scholar