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Nutritional outcome and immunocompetence in mice fed on a diet containing raw field beans (Vicia faba, var. minor) as the source of protein

Published online by Cambridge University Press:  09 March 2007

J. Alfredo Martínez ,
M. Teresa Macarulla ,
Rafael Marcos  and
Jesús Larralde
J. Alfredo Martínez
Affiliation:
Department of Nutrition and Food Science, University of País Vasco, 01007, Vitoria, Spain
M. Teresa Macarulla
Affiliation:
Department of Nutrition and Food Science, University of País Vasco, 01007, Vitoria, Spain
Rafael Marcos
Affiliation:
Department of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain
Jesús Larralde
Affiliation:
Department of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain
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Abstract

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Feeding growing mice on diets containing raw field beans (Vicia faba var. minor) as the only source of protein brought about an impairment in growth, muscle mass and liver weight. No changes in food consumption were observed, but the food intake:weight gain ratio was increased in those animals. Plasma protein, triacylglycerols and cholesterol values were not affected by the dietary treatment although serum glucose and zinc levels fell after legume intake as well as the number of circulating erythrocytes. The relative enlargement of thymus and spleen in the legume-fed mice was apparently accompanied by a reduction in the cell number and an increase in cell size, while the protein synthesis capacity followed differentiated patterns in both tissues when assessed through protein, DNA and RNA determinations. The haemagglutination titres and the number of rosette-forming cells were lower in those animals fed on the field bean diet as well as the splenic lymphocyte responses to phytohaemagglutinin, Concanavalin A or lipopolysaccharide mitogens used to evaluate the functional status of T and B lymphocytes. The present study describes, apparently for the first time in mice, the involvement of field bean intake in some immunological disturbances affecting both humoral- and cell-mediated aspects of the immune response

Keywords

Field bean (Vicia faba L.)ImmunocompetenceMiceGrowthNutritional status
Type
Nutritional Effects of Natural Toxicants
Information
British Journal of Nutrition , Volume 68 , Issue 2 , September 1992 , pp. 493 - 503
Copyright
Copyright © The Nutrition Society 1992

References

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