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Nutritional anaemia in pregnant Beninese women: consequences on the haematological profile of the newborn

Published online by Cambridge University Press:  09 March 2007

Serge Hercberg ,
Pilar GalÁn ,
Michel Chauliac ,
Anne-Marie Masse-Raimbault ,
Michel Devanlay ,
Semiou Bileoma ,
Eusebe Alihonou ,
Isidore Zohoun ,
Jean-Philippe Christides  and
Geneviève Potier De Courcy
Serge Hercberg
Affiliation:
Centre de Recherche sur les Anémies Nutritionnelles, ISTA, CNAM, 292 rue St Martin, Paris F-75003, France
Pilar GalÁn
Affiliation:
Centre de Recherche sur les Anémies Nutritionnelles, ISTA, CNAM, 292 rue St Martin, Paris F-75003, France
Michel Chauliac
Affiliation:
Centre International de I'Enfance, Paris, France
Anne-Marie Masse-Raimbault
Affiliation:
Centre International de I'Enfance, Paris, France
Michel Devanlay
Affiliation:
Hopital Albert Chenevier, Créteil, France
Semiou Bileoma
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Eusebe Alihonou
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Isidore Zohoun
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Jean-Philippe Christides
Affiliation:
CNRS, Meudon-Bellevue, France
Geneviève Potier De Courcy
Affiliation:
CNRS, Meudon-Bellevue, France
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Abstract

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1. An assessment of iron and folic acid status, blood thick film and haemoglobin (Hb) electrophoresis was performed on 126 pregnant women (and their newborn infants) and in ninety-five menstruating women in Cotonou (Benin).

2. Anaemia (according to the World Health Organization (1972)) was observed in 55% of pregnant women and in 39% of menstruating women.

3. Fe-deficiency was defined as a low serum ferritin concentration (12μg/l or less), combined with a low transferrin saturation (less than 16%) or a high erythrocyte protoporphyrin level (more than 3 μg/g Hb), or both. A moderate elevation in the serum ferritin concentration (between 13 and 50 μg/l), associated with a low transferrin saturation or a high erythrocyte protoporphyrin level, or both, indicated Fe-deficiency in an inflammatory context. Fe-deficiency was present in 73% of pregnant women and in 41% of menstruating women.

4. Folate deficiency (defined as erythrocyte folate below 160 μg/l) was observed in 45% of pregnant women.

5. In pregnant women, anaemia was associated with Fe-deficiency in 83% of cases and with folate deficiency in 48% of cases.

6. Haemoglobinopathies were mainly heterozygous and did not seem to contribute significantly to anaemia. Intensity of malaria was not related to Hb level, but Plasmodium falcipurum was found in 99% of subjects.

7. Hb concentration and mean corpuscular volume were significantly lower in babies born of Fe-deficient mothers than in babies born of Fe-sufficient mothers. Hb concentration in newborn infants was positively correlated with maternal serum ferritin.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 2 , March 1987 , pp. 185 - 193
Copyright
Copyright © The Nutrition Society 1987

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