Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-26T13:28:46.203Z Has data issue: false hasContentIssue false
  • English
  • Français

Normal folic acid metabolism in iron-deficient rats

Published online by Cambridge University Press:  09 March 2007

D. G. Burns  and
G. H. Spray
D. G. Burns
Affiliation:
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford
G. H. Spray
Affiliation:
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Weanling rats were fed on an iron-deficient diet without added folic acid and litter-mate controls received the same diet supplemented with Fe. Groups of deficient and control animals were killed at intervals of up to 88 days and glutamate formiminotransferase activity in liver and folic acid activity in liver and serum were measured.

2. No differences were found between the results from the deficient and control animals, although the deficient diet produced marked falls in haemoglobin, packed cell volume and serum iron.

3. In a second experiment folic acid was added to the diets and twelve rats received the Fe-deficient diet and their litter-mates were fed on the Fe-supplemented diet for 91 days. No differences were found in the activity of glutamate formiminotransferase purified from the combined livers of the two groups.

Type
Research Article
Information
British Journal of Nutrition , Volume 23 , Issue 3 , August 1969 , pp. 665 - 670
Copyright
Copyright © The Nutrition Society 1969

References

Bennett, M. C., Berry, V., Chanarin, I. & Ardeman, S. (1964). J. clin. Path. 17, 27.CrossRefGoogle Scholar
Bothwell, T. H. & Mallett, B. (1955). Biochem. J. 59, 599.CrossRefGoogle Scholar
Burns, D. G. (1968). Observations on the effects of iron deficiency and anticonvulsant drugs on folate metabolism in the rat. D. Phil. Thesis, University of Oxford.Google Scholar
Cameron, D. G. & Watson, G. M. (1948). Blood 3, 292.Google Scholar
Chanarin, I., Rothman, D. & Berry, V. (1965). Br. med. J. i, 480.CrossRefGoogle Scholar
Darke, S. J. & White, C. (1950). Br. J. Nutr. 4, 9.CrossRefGoogle Scholar
Grossowicz, N., Rachmilewitz, M. & Izak, G. (1963). Proc. Soc. exp. Biol. Med. 112, 486.CrossRefGoogle Scholar
Layne, E. (1957). In Methods in Enzymology. Vol. 3, p. 451. [Colowick, S. P. and Kaplan, N. O., editors.] New York: Academic Press Inc.Google Scholar
MacDonald, R. A., Jones, R. S. & Pechet, G. S. (1965). Archs Path. 80, 153.Google Scholar
McCall, M. G., Newman, G. E., O'Brien, J. R. P., Valberg, L. S. & Witts, L. J. (1962). Br. J. Nutr. 16, 297.CrossRefGoogle Scholar
O'Dell, B. L., Vandenbelt, J. M., Bloom, E. S. & Pfiffner, J. J. (1947). J. Am. chem. Soc. 69, 250.CrossRefGoogle Scholar
Spray, G. H. (1964). J. clin. Path. 17, 660.CrossRefGoogle Scholar
Velez, H., Restrepo, A., Vitale, J. J. & Hellerstein, E. E. (1966). Am. J. clin. Nutr. 19, 27.Google Scholar
Vitale, J. J., Restrepo, A., Velez, H., Riker, J. B. & Hellerstein, E. E. (1966). J. Nutr. 88, 315.Google Scholar
Vitale, J. J., Streiff, R. R. & Hellerstein, E. E. (1965). Lancet ii, 393.CrossRefGoogle Scholar