Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-23T18:17:54.161Z Has data issue: false hasContentIssue false
  • English
  • Français

Nτ-Methylhistidine in human skeletal and smooth muscle proteins

Published online by Cambridge University Press:  08 December 2008

I. B. Holbrook ,
E. Gross  and
M. H. Irving
I. B. Holbrook
Affiliation:
Department of Surgery, Hope HospitalUniversity of Manchester School of Medicine, Salford M6 8HD
E. Gross
Affiliation:
Department of Surgery, Hope HospitalUniversity of Manchester School of Medicine, Salford M6 8HD
M. H. Irving
Affiliation:
Department of Surgery, Hope HospitalUniversity of Manchester School of Medicine, Salford M6 8HD
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Fifteen pieces of rectus abdominus muscle and fifteen pieces of taenia muscle were removed from patients undergoing various surgical procedures.

2. The muscles were extracted, hydrolysed and the content of Nτ-methylhistidine was measured.

3. The rectus muscles contained 3.13±0.7 μmols Nτ-methylhistidine/g fat-free dry solid andthe taenia muscles 2.4±0.6 μmols/g fat-free dry solid. There was a statistically significant difference (P < 0.05) between these values using the Student's unpaired t test, although this could have been due to contamination of the taenia muscles with connective tissue.

4. The muscle content of Nτ-methylhistidine was at least 40% higher than the only other reported value and therefore the method of calculating muscle protein breakdown based on Nτ-methylhistidine excretion requires revision.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 1 , January 1979 , pp. 15 - 17
Copyright
Copyright © The Nutrition Society 1979

References

Asatoor, A. M. & Armstrong, M. D. (1967). Biochem. Biophys. Res. Commun. 26, 168.Google Scholar
Fitzpatrick, G. F., Meguid, M. M., Gitlitz, P. H. & Brennan, M. F. (1977). Metabolism 26, 477.Google Scholar
Funabiki, R., Watanabe, Y., Nishizawa, N. & Hareyama, S. (1976). Biochim. biophys. Acta 451, 143.Google Scholar
Gross, E., Holbrook, I. B. & Irving, M. H. (1978). Br. J. Surg. (In the Press.)Google Scholar
Haverberg, L. N., Deckelbaum, L., Bilmazes, C., Munro, H. N. & Young, V. R. (1975). Biochem. J. 152, 503.Google Scholar
Haverberg, L. N., Munro, H. N. & Young, V. R. (1974). Biochim. biophys. Acta 371, 226.Google Scholar
Haverberg, L. N., Omstedt, P. T., Munro, H. N. & Young, V. R. (1975). Biochim. biophys. Acta 405, 67.Google Scholar
Johnson, P., Harris, C. I. & Perry, S. V. (1967). Biochem. J. 105, 361.Google Scholar
Johnson, P. & Perry, S. V. (1970). Biochem. J. 199, 293.Google Scholar
Long, C. L., Haverberg, L. N., Young, V. R., Kinney, J. M., Munro, H. N. & Geiger, J. W. (1975). Metabolism 24, 929.Google Scholar
Narasinga Rao, B. S. & Nagabhushan, V. S. (1973). Life Sci. 12, 205.Google Scholar
Nishizawa, N., Funabiki, R. & Hareyama, S. (1975). J. Nutr. Sci. 21, 383.Google Scholar
Wannemacher, R. W., Dintennan, R. E., Pekarek, R. S., Bartelloni, P. J. & Beisel, W. R. (1975). Am. J. clin. Nutr. 28, 110.Google Scholar
Williamson, D. H., Farrell, R., Kerr, A. & Smith, R. (1977). Clin. Sci. mol. Med. 52, 527.Google Scholar
Young, V. R., Alexis, S. C., Baliga, B. S., Munro, H. N. & Muecke, W. (1972). J. biol. Chem. 247, 3592.Google Scholar
Young, V. R., Baliga, B. S., Alexis, S. C. & Munro, H. N. (1970). Biochim. biophys. Acta 199, 297.Google Scholar
Young, V. R.Haverberg, L. N., Bilmazes, C. & Munro, H. N. (1973). Metabolism 22, 1429.Google Scholar