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Methionine deficiency and iron retention in the rat*

Published online by Cambridge University Press:  09 March 2007

Nathan Kaufman ,
Janis V. Klavins  and
Thomas D. Kinney
Nathan Kaufman
Affiliation:
Department of Pathology, Duke University Medical Center, Durham, NC, USA
Janis V. Klavins
Affiliation:
Department of Pathology, Duke University Medical Center, Durham, NC, USA
Thomas D. Kinney
Affiliation:
Department of Pathology, Duke University Medical Center, Durham, NC, USA
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Abstract

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1. Methionine-deficient diets were given to rats for 4 weeks. 2. This resulted in a decrease in total body iron, due to a decrease either in Fe absorption or Fe retention. 3. There was inhibition of growth, development of anaemia and a shift of body Fe to the liver. 4. There were no histological alterations which could be interpreted as specific to methionine deficiency. 5. These findings were different from reports of effects of ethionine in which there is an increased Fe absorption and various tissue alterations, including pancreatic acinar and liver damage.

Type
Research Article
Information
British Journal of Nutrition , Volume 20 , Issue 4 , December 1966 , pp. 813 - 817
Copyright
Copyright © The Nutrition Society 1966

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