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Metabolism of riboflavin:reduction of 7,s-dimethyl-10-formylmethylisoalloxazine by an enzyme in liver

Published online by Cambridge University Press:  24 July 2007

D. W. West  and
E. C. Owen
D. W. West
Affiliation:
Biochemistry Department, Hannah Research Institute, Ayr KA6 5HL
E. C. Owen
Affiliation:
Biochemistry Department, Hannah Research Institute, Ayr KA6 5HL
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Abstract

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1. The riboflavin metabolite, 7,8-dimethyl-10-formylmethylisoalloxazine, has been shown to be reduced to the corresponding alcohol, 7,8-dimethyl-10-(2′-hydroxyethyl)isoalloxazine, by an enzyme present in the soluble fraction of liver and kidney.

2. The enzyme is present in these organs in a number of species but is especially prevalent in the tissues of ruminants. It appears to be different from the normal hepatic alcohol dehydrogenase in that it uses NADPH rather than NADH as cofactor.

Type
Research Article
Information
British Journal of Nutrition , Volume 29 , Issue 1 , January 1973 , pp. 43 - 50
Copyright
Copyright © The Nutrition Society 1973

References

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