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Metabolism of erythritol in humans: Comparison with glucose and lactitol

Published online by Cambridge University Press:  09 March 2007

Martin Hiele ,
Yvo Ghoos ,
Paul Rutgeerts  and
Gaston Vantrappen
Martin Hiele
Affiliation:
Departments of Medicine and of Medical Research, Gastrointestinal Research Center, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Yvo Ghoos
Affiliation:
Departments of Medicine and of Medical Research, Gastrointestinal Research Center, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Paul Rutgeerts
Affiliation:
Departments of Medicine and of Medical Research, Gastrointestinal Research Center, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Gaston Vantrappen
Affiliation:
Departments of Medicine and of Medical Research, Gastrointestinal Research Center, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
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Abstract

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The metabolism of erythritol was assessed in six normal volunteers by measuring the amount of 13CO2 excretion and H2 excretion in breath, and erythritol in urine after intake of 25 g 13C-labelled erythritol. The results were compared with the same variables obtained after intake of 25 g 13C-labelled glucose and13C-labelled lactitol. In addition, the H2 production by faecal flora supplemented with small amounts of erythritol, glucose and lactitol was measured in vitro, as an index of bacterial metabolism of non-absorbed substrate. In contrast to the results obtained after intake of glucose and lactitol, no increase in breath 13CO2 and H2 was observed after intake of erythritol, and erythritol was nearly completely recovered in urine. The in vitro experiments showed that no H2 was formed by faecal flora from erythritol as compared with glucose and lactitol. It is concluded that erythritol is a substrate that is readily absorbed, and undergoes no metabolism by the host. If part of it escapes absorption, it is not metabolized by faecal flora.

Keywords

Erythritol metabolismGlucoseLactitolHumans
Type
Carbohydrate Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 169 - 176
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Ebiner, J. R., Acheson, K. J., Doerner, A., Maeder, E., Arnaud, M. J., Jéquier, E. & Felber, J. P. (1979). Comparison of carbohydrate utilization in man using indirect calorimetry and mass spectrometry after an oral load of 100 g naturally-labelled [13C]glucose. British Journal of Nutrition 41, 419–429.CrossRefGoogle ScholarPubMed
Grimble, G. K., Patil, D. H. & Silk, D. B. A. (1988). Assimilation of lactitol, an ‘unabsorbed’ disaccharide in the normal human colon. Gut 29, 1666–1671.CrossRefGoogle ScholarPubMed
Haycock, G. B., Schwatz, G. J. & Wisotsky, D. H. (1978). Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. Journal of Pediatrics 93, 62–66.CrossRefGoogle ScholarPubMed
Hiele, M., Ghoos, Y., Rutgeerts, P. & Vantrappen, G. (1988 a). Measurements of the rate of assimilation of oligo- and polysaccharides by 13CO2, breath tests and isotope ratio mass spectrometry. Biomedical and Environmental Mass Spectrometry 16, 133–135.CrossRefGoogle ScholarPubMed
Hiele, M., Ghoos, Y., Rutgeerts, P., Vantrappen, G., Carchon, H. & Eggermont, E. (1988 b). 13CO2, breath test using naturally 13C-enriched lactose for detection of lactose deficiency in patients with gastrointestinal symptoms. Journal of Laboratory and Clinical Medicine 112, 193–200.Google ScholarPubMed
Hiele, M., Ghoos, Y., Rutgeerts, P. & Vantrappen, G. (1989). Starch digestion in normal subjects and patients with pancreatic disease, using a 13CO2, breath test. Gastroenterology 96, 503–509.CrossRefGoogle ScholarPubMed
Klein, P. D. & Klein, E. R. (1985). Applications of stable isotopes to pediatric nutrition and gastroenterology: measurement of nutrient absorption and digestion using 13C. Journal of Pediatric Gastroenterology and Nutrition 4, 9–19.CrossRefGoogle ScholarPubMed
Lacroix, M., Mosord, F., Pontus, M., Lefebvre, P., Luyckx, A. & Lopez-Habib, G. (1973). Glucose naturally labelled with carbon-13: use for metabolic studies in man. Science 181, 445–446.CrossRefGoogle ScholarPubMed
McGaw, B. A., Milne, E. & Duncan, G. J. (1988). A rapid method for the preparation of combustion samples for stable carbon isotope analysis by isotope ratio mass spectrometry. Biomedical and Environmental Mass Spectrometry 16, 269–273.CrossRefGoogle Scholar
Miller, T. L. & Wolin, M. J. (1979). Fermentations by saccharolytic intestinal bacteria. American Journal of Clinical Nutrition 32, 164–172.CrossRefGoogle ScholarPubMed
Oku, T. & Noda, J. (1990). Influence of chronic ingestion of newly developed sweetener, erythritol on growth and gastrointestinal function of the rats. Nutrition Research 10, 987–996.CrossRefGoogle Scholar
SAS Institute Inc. (1988). SAS/STAT User's Guide, releuse 6.03 ed. Cary, NC: SAS Institute Inc.Google Scholar
Schoeller, D. A., Klein, P. D., Watkins, J. B., Heim, T. & MacLean, W. C. (1980). 13C abundances of nutrients and the effect of variations in 13C isotopic abundances of test meals formulated for l3CO, breath tests. American Journal of Clinical Nutrition 33, 2375–2385.CrossRefGoogle Scholar
Shreeve, W. W., Cerasi, E. & Luft, R. (1970). Metabolism of [2-14C]-pyruvate in normal, acromegalic and HGH- treated human subjects. Acta Endocrinologica 65, 155–169.Google ScholarPubMed
Shulman, R. J., Wong, W. W., Irving, C. S., Nichols, B. L. & Klein, P. D. (1983). Utilization of dietary cereal by young infants. Journal of Pediatrics 103, 23–28.CrossRefGoogle ScholarPubMed
Van Es, A. J. H. (1987). Energy utilization of low digestibility carbohydrates. In Low Digestibility Carbohydrates, pp. 121–127 [Leegwater, D. C., Feron, V. J. and Hermus, R. J. J., editors]. Wageningen: Pudoc.Google Scholar
Van Es, A. J. H., De Groot, L. & Vogt, J. E. (1986). Energy balances of eight volunteers fed on diets supplemented with either lactitol or saccharose. British Journal of Nutrition 56, 545–554.CrossRefGoogle ScholarPubMed