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Metabolic studies of [75Se]selenomethionine and [75Se]selenite in the rat

Published online by Cambridge University Press:  09 March 2007

Christine D. Thomson  and
R. D. H. Stewart
Christine D. Thomson
Affiliation:
Department of Nutrition and Department of Medicine, University of Otago, Dunedin, New Zealand
R. D. H. Stewart
Affiliation:
Department of Nutrition and Department of Medicine, University of Otago, Dunedin, New Zealand
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Abstract

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1. Information was sought concerning the long-term fate of orally and intravenously administered [75Se]selenomethionine and [75Se]selenite in rats.

2. Urinary and faecal radioactivity was assayed during the 1st week and whole-body radio-activity was determined weekly for 16 weeks. Rats were killed at intervals for analysis of 75Se tissue distribution.

3. Intestinal absorption after oral administration was estimated to be 91–93% for selenite and 95–97% for selenomethionine.

4. Urinary excretion of absorbed [75Se]selenite was greater than that of [75Se]selenomethionine during the 1st week.

5. After the 1st week, whole-body retention diminished exponentially at a similar rate in rats given either selenomethionine or selenite. Except for the erythrocytes, 75Se content of individual tissues also decreased exponentially.

6. It appears that, after an initial period, 75Se from either selenomethionine or selenite is metabolized similarly, suggesting that Se from both potential dietary sources is ultimately incorporated into the same metabolic pool.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 30 , Issue 1 , July 1973 , pp. 139 - 147
Copyright
Copyright © The Nutrition Society 1973

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