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Metabolic studies in rats of [75Se]selenomethionine and of 75Se incorporated in vivo into rabbit kidney

Published online by Cambridge University Press:  25 March 2008

Christine D. Thomson ,
R. D. H Stewart  and
Marion F. Robinson
Christine D. Thomson
Affiliation:
Department of Nutrition and Department of Medicine, University of Otago, Dunedin, New Zealand
R. D. H Stewart
Affiliation:
Department of Nutrition and Department of Medicine, University of Otago, Dunedin, New Zealand
Marion F. Robinson
Affiliation:
Department of Nutrition and Department of Medicine, University of Otago, Dunedin, New Zealand
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Abstract

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1. [75Se]selenomethionine was administered to four rabbits and after 4 d their kidneys were removed and homogenized. The long-term fate in rats of an oral dose of this kidney homogenate (RK-75Se) was compared with that of an oral dose of [75Se]selenomethionine mixed with unlabelled rabbit kidney homogenate.

2. Urinary and faecal radioactivities were measured during the 1st week and whole-body radioactivity was determined for 10 weeks. Rats were killed at weekly intervals for 4 weeks for analysis of tissue distribution of 75Se.

3. Intestinal absorption of RK-75Se was 87%; that of [75Se]selenomethionine was 91%. Urinary excretion of absorbed RK-75Se was 13·3% and that of [75Se]selenomethionine was 7·6%, in the 1st week.

4. Whole-body retention of 75Se was greater for [75Se]selenomethione than for RK-75Se but after the 1st week decreased at a similar rate in both groups. Tissue distribution of retained 75Se was also similar in both groups.

5. The initial utilization of 75Se in rabbit kidney is different from that of [75Se]selenomethionine. However, after the 1st week 75Se from these sources appears to be metabolized similarly, suggesting that Se from both is ultimately incorporated into the same metabolic pool.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 33 , Issue 1 , January 1975 , pp. 45 - 54
Copyright
Copyright © The Nutrition Society 1975

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