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Metabolic adaptation to a fat-supplemented diet by the thoroughbred horse

Published online by Cambridge University Press:  09 March 2007

Catherine E. Orme ,
Roger C. Harris ,
David J. Marlin  and
Jane Hurley
Catherine E. Orme
Affiliation:
Department of Physiology, Animal Health Trust, PO Box 5, Newmarket CB8 7DW
Roger C. Harris
Affiliation:
Equine Sports Medicine Centre, Royal Veterinary College, North Mymms AL9 7TA
David J. Marlin
Affiliation:
Department of Physiology, Animal Health Trust, PO Box 5, Newmarket CB8 7DW
Jane Hurley
Affiliation:
Spillers Speciality Feeds, Dalgety Agriculture Ltd, Aztec West, Bristol
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Abstract

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Following 10 weeks of fat supplementation a group of aerobically trained thoroughbred horses exhibited a significant decrease in postprandial plasma triacylglycerol concentration. This decrease was associated with a mean 50% increase in plasma total lipase activity following pentosan polysulfate administration and an increase in postprandial plasma cholesterol concentration. A significant increase in the activity of muscle citrate synthase (EC 4.1.3.7), expressed as a ratio to the total fractional area occupied by type I and type IIa muscle fibres, was also observed. No significant change in the concentration of resting muscle glycogen or triacylglycerol occurred as a result of fat supplementation. These results suggest that there was improved management of the fat load and that the triacylglycerol-clearing capacity of the horses was increased as a result of fat supplementation. It is suggested that the increase in plasma total lipase activity following pentosan polysulfate administration may have reflected an increase in muscle lipoprotein lipase (EC 3.1.1.34) activity, which would increase the capacity of muscle for free fatty acid uptake from circulating triacylglycerol-rich plasma lipoproteins. Fat supplementation may also enhance the oxidative capacity of muscle, as suggested by the significant increase in muscle citrate synthase and the trend towards an increase in β-hydroxyacyl CoA dehydrogenase (EC 1.1.1.35) following 10 weeks of fat supplementation.

Keywords

Dietary fatLipase activityHorse
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 78 , Issue 3 , September 1997 , pp. 443 - 458
Copyright
Copyright © The Nutrition Society 1997

References

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