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Messenger RNA levels of plasma proteins following fasting

Published online by Cambridge University Press:  09 March 2007

Felice A. De Jong ,
Geoffrey J. Howlett  and
Gerhard Schreiber
Felice A. De Jong
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
Geoffrey J. Howlett
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
Gerhard Schreiber
Affiliation:
Biotechnology Australia Pty Ltd, Roseville, NSW 2069, Australia
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Abstract

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1. The effect of fasting on hepatic mRNA levels of seven plasma proteins was examined in the rat.

2. The levels of mRNA were measured directly in cytoplasmic extracts by hybridization to specific 32P-labelled cDNA probes.

3. Following a 48 h period of fasting, the mRNA levels of apolipoprotein E, apolipoprotein A-IV, albumin, transferrin, and transthyretin decreased by 15–30%, while apolipoprotein A-II decreased by 78% compared with non-fasted control rats. The mRNA for apolipoprotein A-I increased by 33%.

4. These findings suggest that mRNA levels in the liver following fasting are regulated independently and variations in these levels may be due to differences in transcription rates or mRNA stability.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 81 - 86
Copyright
Copyright © The Nutrition Society 1988

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