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Maternal nutrition in early-mid gestation and placental size in sheep

Published online by Cambridge University Press:  09 March 2007

Lynne Clarke ,
Lindsay Heasman ,
Darren T. Juniper  and
Michael E. Symonds
Lynne Clarke
Affiliation:
School of Animal and Microbial Sciences and University of Reading, Whiteknights, Reading RG6 6AJ, UK
Lindsay Heasman
Affiliation:
Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK
Darren T. Juniper
Affiliation:
Department of Agriculture, University of Reading, Whiteknights, Reading RG6 6AJ, UK
Michael E. Symonds*
Affiliation:
Department of Child Health, University Hospital, Queen's Medical School, Nottingham NG7 2UH, UK
*
*Corresponding author:Dr Michael Symonds, fax +44 (0) 115 970 9382, email [email protected]
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Abstract

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We investigated the influence of restricted maternal nutrition between 30 and 80 d gestation on placental growth. Singleton-bearing ewes were fed on either 0.6 (i.e. nutrient restricted) times their energy requirements or 2.25 times this amount (i.e. controls) up to 80 d gestation, when their placentas and fetuses were sampled and analysed. Nutrient-restricted ewes lost body condition score but not body weight and had lower plasma thyroid hormone concentrations than controls, but there were no differences in plasma glucose, non-esterified fatty acids or 3-hydroxybutyrate concentrations between groups. There was no effect of maternal nutrient restriction on fetal weight, conformation or organ weights with the exception of brain weight which was lower in nutrient-restricted ewes. Nutrient restriction had no effect on total placental weight, or proportion of inverted placentomes, but was associated with an increased abundance of small placentomes and decreased weight of the fetal but not maternal components of the placenta. Fetal cotyledons from nutrient-restricted ewes also had a lower DNA but higher haemoglobin concentration than those sampled from controls. The plasma concentration of triiodothyronine in umbilical cord plasma was also increased in fetuses from nutrient-restricted ewes. In conclusion, maternal nutrient restriction during early-mid gestation is associated with a smaller placenta.

Keywords

PlacentaregnancySheep
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 4 , April 1998 , pp. 359 - 364
Copyright
Copyright © The Nutrition Society 1998

References

Agricultural and, Food Research, Council Technical, Committee on, Responses to Nutrients (1992) Energy and Protein Requirements of Ruminants. Report no. 9, pp. 812–815. Wallingford: CAB INTERNATIONAL.Google Scholar
Alexander, G (1964) Studies on the placenta of the sheep (Ovis aries L) placental size. Journal of Reproduction and Fertility 7, 289–305.CrossRefGoogle ScholarPubMed
Bauer, MK, Breier, BH, Harding, JE, Veldhuis, JD & Gluckman, PD (1995) The fetal somatotropic axis during long term maternal undernutrition in sheep: evidence for nutritional regulation in utero. Endocrinology 136, 1250–1257.Google Scholar
Bzoskie, L, Blount, L, Kashiwai, K, Tseng, Y-T, Hay, WW & Padbury, JF (1995) Placental norepinephrine clearance: in vivo measurement and physiological role. American Journal of Physiology 269, E145–E149.Google ScholarPubMed
Clarke, L, Bird, JA, Lomax, MA & Symonds, ME (1996) Effect of β3-adrenergic agonist (Zeneca D7114) on thermoregulation in near-term lambs delivered by Cesarean section. Pediatric Research 40, 330–336.Google Scholar
Clarke, L, Darby, CJ, Lomax, MA & Symonds, ME (1994) Effect of ambient temperature during 1 st day of life on thermoregulation in lambs delivered by Cesarean section. Journal of Applied Physiology 76, 1481–1488.Google Scholar
Clarke, L, Yakubu, DP & Symonds, ME (1997) Influence of maternal body weight on size, conformation and survival of newborn lambs. Reproduction, Fertility and Development 9, 509–514.CrossRefGoogle ScholarPubMed
Dauncey, MJ (1990) Thyroid hormones and thermogenesis. Proceedings of the Nutrition Society 49, 203–215.CrossRefGoogle ScholarPubMed
Ehrhardt, RA & Bell, AW (1995) Growth and metabolism of the ovine placenta during mid-gestation. Placenta 16, 727–741.CrossRefGoogle ScholarPubMed
Gunn, T & Gluckman, PD (1995) Perinatal thermogenesis. Early Human Development 42, 169–183.Google Scholar
Harding, JE, Jones, CT & Robinson, JS (1985) Studies on experimental growth retardation in sheep. The effects of a small placenta in restricting transport to and growth of the fetus. Journal of Developmental Physiology 7, 453–457.Google ScholarPubMed
Hinegardner, RT (1971) An improved fluorometric assay for DNA. Analytical Biochemistry 39, 197–201.Google Scholar
Lowry, OH, Rosebrough, NJ, Farr, AL & Randall, RJ (1951) Protein measurement with the Folin reagent. Journal of Biological Chemistry 193, 141–150.Google Scholar
Ma, L, Burton, KA, Saunders, JC & Dauncey, MJ (1992) Thermal and nutritional influences on tissue levels of insulin-like growth factor mRNA and peptide. Journal of Thermal Biology 17, 89–95.Google Scholar
McCrabb, GJ, Egan, AR & Hosking, BJ (1991) Maternal under-nutrition during mid-pregnancy in sheep. Placental size and its relation to calcium transfer during late pregnancy. British Journal of Nutrition 65, 157–168.Google Scholar
McCrabb, GJ, Egan, AR & Hosking, BJ (1992) Maternal under-nutrition during mid-pregnancy in sheep: variable effects on placental growth. Journal of Agricultural Science, Cambridge 118, 127–132.CrossRefGoogle Scholar
Maruo, T, Matsuo, H & Mochizuki, M (1991) Thyroid hormone as a biological amplifier of differentiated trophoblast function in early pregnancy. Acta Endocrinologica 127, 118–122.Google Scholar
Nunez, J (1984) Effects of thyroid hormones during brain differentiation. Molecular Cellular Endocrinology 37, 125–132.Google Scholar
Owens, JA, Owens, PC & Robinson, JS (1995) Experimental restriction of fetal growth. In Fetus and Neonate, Vol. 3. Growth, pp. 139–175 [Hanson, MA, Spencer, JAD and CH, Rodeck, editors]. Cambridge University Press: Cambridge.Google Scholar
Robinson, JJ (1990). Nutrition in the reproduction of farm animals. Nutrition Research Reviews 3, 253–276.Google Scholar
Robinson, JJ, McDonald, I, Fraser, C & Crofts, RMJ (1977) Studies on reproduction in prolific ewes. 1. Growth of the conceptus, Journal of Agricultural Science, Cambridge 88, 539–552.CrossRefGoogle Scholar
Robinson, JS, Owens, JA, DeBarro, T, Lok, F & Chidzanja, S (1994) Maternal nutrition and fetal growth. In Early Fetal Growth and Development, pp. 317–329 [SmithRHT Ward, SK RHT Ward, SK, Donnai, D, editors]. London: RCOG Press.Google Scholar
Roti, E, Fang, SL, Green, K, Emerson, CH & Braverman, LE (1981) Human placenta is an active site of thyroxine and 3,3',5-triiodothyronine tyrosol ring deiodination. Journal of Clinical Endocrinology and Metabolism 53, 498–501.CrossRefGoogle Scholar
Russel, AJF, Doney, JM & Gunn, RG (1969) Subjective assessment of body fat in live sheep. Journal of Agricultural Science, Cambridge 72, 451–454.CrossRefGoogle Scholar
Schneider, H (1996) Ontogenic changes in the nutritive function of the placenta. Placenta 17, 15–26.Google Scholar
Symonds, ME (1995) Pregnancy, parturition and neonatal development–interactions between nutrition and thyroid hormones. Proceedings of the Nutrition Society 54, 329–343.Google Scholar
Symonds, ME, Bryant, MJ & Lomax, MA (1986) The effect of shearing on the energy metabolism of the pregnant ewe. British Journal of Nutrition 56, 635–643.Google Scholar
Vatnick, I, Schoknecht, PA, Darrigrand, R & Bell, AW (1991) Growth and metabolism of the placenta after unilateral fetectomy in twin pregnant ewes. Journal of Developmental Physiology 15, 351–356.Google ScholarPubMed