Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-25T01:44:35.920Z Has data issue: false hasContentIssue false
  • English
  • Français

Lymphocyte subpopulations and antibody levels in immunized malnourished children

Published online by Cambridge University Press:  09 March 2007

L. S. Salimonu ,
A. O. K. Johnson ,
A. I. O. Williams ,
G. Iyabo Adeleye  and
B. O. Osunkoya
L. S. Salimonu
Affiliation:
Departments of Chemical Pathology (Immunology Unit), University College Hospital, Ibadan, Nigeria
A. O. K. Johnson
Affiliation:
Departments of Chemical Pathology Paediatrics, University College Hospital, Ibadan, Nigeria
A. I. O. Williams
Affiliation:
Departments of Chemical Pathology (Immunology Unit), University College Hospital, Ibadan, Nigeria
G. Iyabo Adeleye
Affiliation:
Departments of Chemical Pathology General Out-Patients, University College Hospital, Ibadan, Nigeria
B. O. Osunkoya
Affiliation:
Departments of Chemical Pathology (Immunology Unit), University College Hospital, Ibadan, Nigeria
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The proportions of lymphocyte subpopulations (by rosette tests) and the serum antibody levels (using haemagglutination techniques) were estimated in malnourished and well fed Nigerian children before and up to 21 d after immunization with tetanus toxoid or measles virus vaccine.

2. Significantly diminished (P < 0.01) mean percentage T lymphocyte levels and considerably higher mean percentage null cell levels were observed in the malnourished children before immunization with either of the vaccines.

3. There was comparable in vivo increases in percentage T lymphocytes in malnourished and control children following the administration of each antigen.

4. The mean percentage B lymphocyte levels were similar in the control and malnourished children before and after the immunization.

5. There was a slight depression in the tetanus antibody levels (P > 0.2) but a significant diminution (P < 0.01) in measles virus antibody concentrations in the malnourished children.

6. Rise in mean percentage T lymphocytes corresponded with the elevation in mean tetanus antibody levels in both malnourished and control children following tetanus toxoid immunization. This was however not the situation in the malnourished children following immunization with measles virus.

7. The observed depressed T lymphocyte number in malnourished children may in practice affect their handling of antigens such as measles virus in vivo.

Type
Papers of direct reference to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 48 , Issue 1 , July 1982 , pp. 7 - 14
Copyright
Copyright © The Nutrition Society 1982

References

REFERENCES

Basten, A. & Howard, J. G. (1973). Contemporary Topics in Immunology, vol. 2, p. 265 [Davies, A. J. S. and Caster, R. L., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Chandra, R. K. (1972). J. Pediat 81, 194.Google Scholar
Chandra, R. K. (1974 a). Br. med. J. iii, 608.CrossRefGoogle Scholar
Chandra, R. K. (1974 b). In Progress in Immunology II, vol. 4, p. 355 [Brent, L. and Holborrow, J., editors]. Amsterdam: North Holland.Google Scholar
Chandra, R. K. (1975). Br. med. J. ii, 583.CrossRefGoogle Scholar
Chandra, R. K. (1977). Paediatrics, Springfield 59, 423.CrossRefGoogle Scholar
Chollet, P. H., Chassagne, J., Phillipe, P., Vuillaume, C., Maublant, J., Gauvin, H., Rey, M. & Plagne, R. (1979). Clin. exp. Immun. 37, 152.Google Scholar
Dresser, D. W. & Tao, T. W. (1975). Immunology 28, 443.Google Scholar
Ferguson, A. C., Lawlor, C. J., Neumann, C. G., Oh, W. & Stiehm, E. R. (1974). J. Pediat. 85, 717.CrossRefGoogle Scholar
Gandra, Y. R. & Scrimshaw, N. S. (1961). Am. J. clin. Nutr. 9, 159.CrossRefGoogle Scholar
Gotoff, S. P. (1973). In Immunologic Disorders in Infants and Children, p. 321 [Stiehm, E. R. and Fulginiti, V. A., editors]. Philadelphia: W. B. Saunders.Google Scholar
Hafez, M., Aref, G. H., Mahareb, S. W., Kassem, A. S., El Tahhan, H., Rizk, Z., Mahfonz, R. & Saad, K. (1977). J. trop. Med. Hyg. 80, 36.Google Scholar
Heyworth, B., Moore, D. L. & Brown, J. (1975). Clin. exp. Immun. 22, 72.Google Scholar
Hodges, R. E., Bean, W. N., Ohlson, M. A. & Bleiler, R. E. (1962). Am. J. clin. Nutr. 11, 187.CrossRefGoogle Scholar
Jondal, M., Holm, C. & Wigzell, H. (1972). J. expl Med. 136, 207.CrossRefGoogle Scholar
Klaus, G. G. & Cross, A. M. (1974). Cell. Immun. 14, 226.CrossRefGoogle Scholar
Lancet (1970). Lancet ii, 302.Google Scholar
McFarlane, H., Reddy, S., Cooke, A., Long, O., Onabamiro, M. O. & Houba, J. E. (1970). Trop. Geog. Med. 22, 61.Google Scholar
Morley, D. (1969). Br. med. J. i, 297.CrossRefGoogle Scholar
Neumann, C. G., Stiehm, E. R., Swenseid, M., Ferguson, A. C. & Lawlor, G. (1977). In Malnutrition and the Immune Response, p. 77 [Suskind, R. M., editor]. New York: Raven Press.Google Scholar
Olarte, J., Cravioto, J. & Campos, B. (1956). Boln. med. Hosp. infant., Méx 13, 467.Google Scholar
Salimonu, L. S. (1980). Immune responses and a serum inhibitory substance in malnourished children. PhD Thesis. University of Ibadan, Nigeria.Google Scholar
Salimonu, L. S., Johnson, A. O. K., Williams, A. I. O., Adeleye, G.Iyabode, & Osunkoya, B. O. (1982). Clin. expl Immun. 47 (In the Press).Google Scholar
Salimonu, L. S. & Osunkoya, B. O. (1980). Am. J. clin. Nutr. 33, 2699.CrossRefGoogle Scholar
Scrimshaw, N. S. & Behar, M. (1961). Science N. Y. 133, 2039.CrossRefGoogle Scholar
Sengar, D. P. S. & Terasaki, P. I. (1971). Transplantation 2, 260.CrossRefGoogle Scholar
Sever, J. L. (1962). J. Immun. 88, 320.CrossRefGoogle Scholar
Stavitsky, A. B. (1954). J. Immun. 72, 360.CrossRefGoogle Scholar
Taylor, R. R. & Wortis, H. H. (1968). Nature, Lond. 220, 927.CrossRefGoogle Scholar
Trowell, H. C. (1949). Trans. Roy. Soc. trop. Med. Hyg. 42, 417.CrossRefGoogle Scholar
Unanue, E. R. (1970). J. Immun. 105, 1339.CrossRefGoogle Scholar
Williams, C. D. (1953). J. Am. med. Ass. 153, 1280.Google Scholar