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Low-iodine diet for the production of severe I deficiency in marmosets (Callithrix jacchus jacchus)

Published online by Cambridge University Press:  09 March 2007

M. T. Mano ,
B. J. Potter ,
G. B. Belling  and
B. S. Hetzel
M. T. Mano
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
B. J. Potter
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
G. B. Belling
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
B. S. Hetzel
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
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Abstract

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1. A low-iodine diet consisting of maize, peas (Pisum sativum), torula yeast, meat meal, maize oil and added vitamins, minerals and amino acids was given to eight pairs of adult, common cotton-eared marmosets (Caliithrix jacchus jacchus). Eight control pairs were given the same diet to which potassium iodate was added. Both groups also received low-I apple and deionized water.

2. The diet provided adequate nutrition, as confirmed by the maintenance of body-weight and good health.

3. In the I-deficient marmosets the concentration of plasma thyroxine was decreased from 140.1 nmol/l to 22.4 nmol/l and thyroid-stimulating hormone increased significantly from 1.8 ng/ml to 9.0 ng/ml compared with control marmosets, thereby indicating severe I deficiency.

4. Compared with newborn offspring from control marmosets, the thyroid glands from the I-deficient offspring showed (a) an increase in weight, (b) a decrease in I content and (c), on histological examination, hyperplasia, hypertrophy and a total absence of colloid material in the follicles.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 2 , September 1985 , pp. 367 - 372
Copyright
Copyright © The Nutrition Society 1985

References

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