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Lipid peroxidation, prostacyclin and thromboxane A2 in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Published online by Cambridge University Press:  09 March 2007

Maeve R. Nolan ,
Seamus Kennedy ,
W. John Blanchflower  and
D. Glenn Kennedy
Maeve R. Nolan
Affiliation:
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast BT4 3SD, Northern Ireland
Seamus Kennedy
Affiliation:
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast BT4 3SD, Northern Ireland
W. John Blanchflower
Affiliation:
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast BT4 3SD, Northern Ireland
D. Glenn Kennedy
Affiliation:
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast BT4 3SD, Northern Ireland
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Abstract

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In a 2×2 balanced factorial experiment the biochemical effects on pigs of two dietary factors were investigated. The first factor was α-tocopherol and Se supplementation and the second factor was supplementation with α-tocopherol-stripped linseed oil. In pigs fed on diets depleted of α-tocopherol and Se, increases in concentrations of markers of lipid peroxidation (4-hydroxynonenal and hexanal) were observed. However, skeletal myopathy was only observed in those pigs fed on diets depleted of α-tocopherol and Se and supplemented with oil. In those pigs, increased lipid peroxidation was observed in heart and supraspinatus muscle. The plasma concentration of thromboxane B2 was increased in pigs fed on diets depleted of α-tocopherol and Se, suggesting an increased tendency towards platelet aggregation. However, this change was reversed in pigs depleted of α-tocopherol and Se, but supplemented with oil. This may have been a consequence of loss of arachidonic acid, the substrate for thromboxane formation, as a result of lipid peroxidation.

Keywords

Vitamin ELipid peroxidation4-HydroxynonenalProstacyclinThromboxane A2
Type
Lipid peroxidation and eicosanoid production in pigs
Information
British Journal of Nutrition , Volume 74 , Issue 3 , September 1995 , pp. 369 - 380
Copyright
Copyright © The Nutrition Society 1995

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