Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-25T02:47:48.509Z Has data issue: false hasContentIssue false
  • English
  • Français

Lipid atherogenic risk markers can be more favourably influenced by the cis-9,trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters

Published online by Cambridge University Press:  09 March 2007

Karine Valeille ,
Daniel Gripois ,
Marie-France Blouquit ,
Maamar Souidi ,
Michel Riottot ,
Jean-Christophe Bouthegourd ,
Colette Sérougne  and
Jean-Charles Martin
Karine Valeille
Affiliation:
ARILAIT Recherches, 42 rue de Châteaudun, 75314 Paris, Cedex 09, France
Daniel Gripois
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Marie-France Blouquit
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Maamar Souidi
Affiliation:
Institut de Radioprotection et de Sûreté Nucléaire, SARAM/DPHD, rue Auguste Lemaire, IRSN, BP 17, 92262 Fontenay-aux-Roses, Cedex, France
Michel Riottot
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Jean-Christophe Bouthegourd
Affiliation:
UMR INRA/INA P-G 914, Physiologie de la Nutrition et du Comportement Alimentaire, 16 rue Claude Bernard, 75231 Paris, Cedex 05, France
Colette Sérougne
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
Jean-Charles Martin*
Affiliation:
Université Paris-Sud, bat 447, campus d'Orsay, 91405 Orsay, Cedex, France
*
*Corresponding author: Dr Jean-Charles Martin, fax +33 1 69 15 70 74, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of our present study was to compare the efficiency of conjugated linoleic acids (CLA) and fish oil in modulating atherogenic risk markers. Adult male hamsters were given a cholesterol-rich diet (0·6 g/kg) for 8 weeks; the diet was supplemented with 5 g cis-9,trans-11-CLA isomer/kg, 12 g CLA mixture (CLA-mix)/kg, 12 g fish oil/kg or 12 g fish oil + 12 g CLA-mix/kg. The plasma cholesterol status was improved only with the cis-9,trans-11-CLA (HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratio, P<0·05), but was of borderline significance for CLA-mix (HDL-cholesterol:LDL-cholesterol ratio, P=0·06), with an increase (33–40 %) in the liver lipoprotein receptors (scavenger receptor-type I and LDL ApoB/E receptor) and HDL-binding protein 2 (P<0·05). A 100 % pigment gallstones incidence and a slight insulin resistance (homeostatic model assessment index) were observed in the CLA-mix-fed hamsters (P=−0·031). In comparison, fish-oil feeding alone improved merely the scavenger receptor-type I and HDL-binding protein 2 liver status and faeces sterol output. For most of our present observations, the concomitant intake of fish oil and CLA-mix gave dominant effects that were exclusive and specific to one or the other oil. In conclusion, part of the beneficial effects of CLA in the present study can be ascribed to the cis-9,trans-11-isomer, and these did not generally overlap with those of fish oil. In addition, the CLA-mix effects are clearly affected by the marine (n-3) fatty acids.

Keywords

Conjugated linoleic acidRumenic acidFish oilLipid atherosclerosis risk markersHamsters
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 2 , February 2004 , pp. 191 - 199
Copyright
Copyright © The Nutrition Society 2004

References

Benito, P, Nelson, GJ, Kelley, DS, Bartolini, G, Schmidt, PC & Simon, V (2001) The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 36, 229–236.CrossRefGoogle ScholarPubMed
Blankson, H, Stakkestad, JA, Fagertun, H, Thom, E, Wadstein, J & Gudmundsen, (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130, 2943–2948.Google ScholarPubMed
Boehler, N, Riottot, M, Ferezou, J, Souidi, M, Milliat, F, Serounge, C, Smith, JL & Lutton, C (1999) Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. J Lipid Res 40, 726–734.CrossRefGoogle ScholarPubMed
Bouthegourd, J-C, Even, PC, Gripois, D, Tiffon, B, Blouquit, MF, Roseau, S, Lutton, C, Tome, D & Martin, JC (2002) A CLA mixture prevents body triglyceride accumulation without affecting energy expenditure in Syrian hamsters. J Nutr 132, 2682–2689.CrossRefGoogle ScholarPubMed
Brown, M, Evans, M & McIntosh, M (2001) Linoleic acid partially restores the triglyceride content of conjugated linoleic acid-treated cultures of 3T3-L1 preadipocytes. J Nutr Biochem 12, 381–387.CrossRefGoogle ScholarPubMed
de Deckere, EA, Van Amelsvoort, JM, McNeill, GP & Jones, P (1999) Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br J Nutr 82, 309–317.CrossRefGoogle ScholarPubMed
Delplanque, B, Loison, C, Le Roy, B, Thaminy, A, Jusselin, I, Verneau, C, Samson, N, Lutton, C & Ruelland, A (2002) From human to hamster: Benefit on plasma and hepatic lipids of high oleic sunflower oil (HOSO) and HOSO-combined vegetable oil (ISIO) compared to olive oil (OO) and sunflower oil (SUN) consumption. ISSFAL wp 36, 71.Google Scholar
Donovan, JM (1999) Physical and metabolic factors in gallstone pathogenesis. Gastroenterol Clin North Am 28, 75–97.CrossRefGoogle ScholarPubMed
Gavino, VC, Gavino, G, Leblanc, MJ & Tuchweber, B (2000) An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr 130, 27–29.CrossRefGoogle Scholar
Hamura, M, Yamatoya, H & Kudo, S (2001) Glycerides rich in conjugated linoleic acid (CLA) improve blood glucose control in diabetic C57BLKS-Lepdb/leprdb mice. J Oleo Sci 11, 889–894.CrossRefGoogle Scholar
Harris, WS (1997) n-3 Fatty acids and serum lipoproteins: animal studies. Am J Clin Nutr 65, 1611S–1616S.CrossRefGoogle ScholarPubMed
Jump, DB (2002) The biochemistry of n -3 polyunsaturated fatty acids. J Biol Chem 277, 8755–8758.CrossRefGoogle ScholarPubMed
Kris-Etherton, PM & Dietschy, J (1997) Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies. Am J Clin Nutr 65, 1590S–1596S.CrossRefGoogle ScholarPubMed
Kritchevsky, D, Tepper, SA, Wright, S, Tso, P & Czarnecki, SK (2000) Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am Coll Nutr 19, 472S–477S.CrossRefGoogle ScholarPubMed
Li, Y, Seifert, MF, Ney, DM, Grahn, M, Grant, AL, Allen, KG & Watkins, BJ (1999) Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed ( n-6) or ( n-3) fatty acids. J Bone Miner Res 14, 1153–1162.CrossRefGoogle ScholarPubMed
Loison, C, Mendy, F, Sérougne, C & Lutton, C (2002) Dietary myristic acid modifies the HDL-cholesterol concentration and liver scavenger receptor BI expression in the hamster. Br J Nutr 87, 199–210.CrossRefGoogle ScholarPubMed
Martin, JC & Valeille, K (2002) Conjugated linoleic acids: all the same or to everyone its own function? Reprod Nutr Dev 42, 525–536.CrossRefGoogle ScholarPubMed
Matthews, DR, Hosker, JP, Rudenski, AS, Naylor, BA, Treacher, DF & Turner, RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.CrossRefGoogle ScholarPubMed
Medina, EA, Horn, WF, Keim, NL, Havel, PJ, Benito, P, Kelley, DS, Nelson, GJ & Erickson, KL (2000) Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids 35, 783–788.CrossRefGoogle ScholarPubMed
Milliat, F, Gripois, D, Blouquit, ME, Ferezou, J, Serounge, C, Fidge, NH & Lutton, C (2000) Short and long-term effects of streptozotocin on dietary cholesterol absorption, plasma lipoproteins and liver lipoprotein receptors in RICO rats. Exp Clin Endocrinol Diabetes 108, 436–446.CrossRefGoogle Scholar
Munday, JS, Thompson, KG & James, KA (1999) Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J Nutr 81, 251–255.CrossRefGoogle ScholarPubMed
Noone, EJ, Roche, HM, Nugent, AP & Gibney, MJ (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243–251.CrossRefGoogle ScholarPubMed
Pariza, MW, Park, Y & Cook, ME (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283–298.CrossRefGoogle ScholarPubMed
Riserus, U, Arner, P, Brismar, K & Vessby, B (2002) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25, 1516–1521.CrossRefGoogle ScholarPubMed
Roche, HM, Noone, E, Nugent, A & Gibney, MJ (2001) Conjugated linoleic acid: a novel therapeutic nutrient? Nutr Res Rev 14, 173–187.CrossRefGoogle ScholarPubMed
Roche, HM, Noone, E, Sewter, C, McBennett, S, Savage, D, Gibney, MJ, O'Rahilly, S & Vidal-Puig, AJ (2002) Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 51, 2037–2044.CrossRefGoogle ScholarPubMed
Rudel, LL, Parks, JS, Hedrick, CC, Thomas, M & Williford, K (1998) Lipoprotein and cholesterol metabolism in diet-induced coronary artery atherosclerosis in primates, role of cholesterol and fatty acids. Prog Lipid Res 37, 353–370.CrossRefGoogle ScholarPubMed
Sakata, R, Ueno, T, Sata, M, Sujaku, K, Tamaki, S, Torimura, T & Tanikawa, K (1997) Formation of black pigment gallstone in a hamster model of experimental cirrhosis. Eur J Clin Invest 27, 840–845.CrossRefGoogle Scholar
Souidi, M, Combettes-Souverain, M, Milliat, F, Eckhardt, ER, Audas, O, Parquet, M, Ferezou, J & Lutton, C (2001) Hamsters predisposed to sucrose-induced cholesterol gallstones (LPN strain) are more resistant to excess dietary cholesterol than hamsters that are not sensitive to cholelithiasis induction. J Nutr 131, 1803–1811.CrossRefGoogle Scholar
Spady, DK & Dietschy, JM (1983) Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat. J Lipid Res 24, 303–315.CrossRefGoogle Scholar
Stangl, GI, Muller, H & Kirchgessner, M (1999) Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins, and its proportion in fasting serum and erythrocyte membranes of swine. Eur J Nutr 38, 271–277.CrossRefGoogle ScholarPubMed
Tsuboyama-Kasaoka, N, Takahashi, M, Tanemura, K, Kim, HJ, Tange, T, Okuyama, H, Kasai, M, Ikemoto, S & Ezaki, O (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 1534–1542.CrossRefGoogle ScholarPubMed
Wilson, TA, Nicolosi, RJ, Chrysam, M & Kritchevsky, D (2000) Conjugated linoleic acid reduces early aortic atherosclerosis greater than linoleic acid in hypercholesterolemic hamsters. Nutr Res 20, 1795–1805.CrossRefGoogle Scholar
Yeung, TCH, Yang, L, Huang, Y, Wang, J & Chen, ZY (2000) Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A:cholesterol acyltransferase in hamsters. Br J Nutr 84, 935–941.CrossRefGoogle Scholar