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Kinetics of the appearance of cereal alkylresorcinols in pig plasma

Published online by Cambridge University Press:  08 March 2007

Anna-Maria Linko ,
Alastair B. Ross ,
Afaf Kamal-Eldin ,
Anja Serena ,
Anna Kirstin Bjørnbak Kjær ,
Henry Jørgensen ,
José L. Peñalvo ,
Herman Adlercreutz ,
Per Åman  and
Knud Erik Bach Knudsen
Anna-Maria Linko*
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Alastair B. Ross
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden Nestlé Research Centre, Lausanne 26, CH-1000, Switzerland
Afaf Kamal-Eldin
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden
Anja Serena
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
Anna Kirstin Bjørnbak Kjær
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
Henry Jørgensen
Affiliation:
Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
José L. Peñalvo
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Herman Adlercreutz
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre and Department of Clinical Chemistry, PO Box 63, University of Helsinki, FIN-00014, Helsinki, Finland
Per Åman
Affiliation:
Department of Food Science, Swedish University of Agricultural Science (SLU), Box 7051, S-750 07 Uppsala, Sweden
Knud Erik Bach Knudsen
Affiliation:
Nestlé Research Centre, Lausanne 26, CH-1000, Switzerland Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, DK-8830 Tjele, Denmark
*
*corresponding author: Dr Anna-Maria Linko, fax +358 9 191 25452, email [email protected]
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Abstract

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Alkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of AR-rich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5d, and arterial and venous AR concentrations were determined over 960min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120min, remained elevated between 120 and 420min, and were re-elevated on refeeding at 480min. In study 2, AR appeared in the plasma after 60min, peaked at 180–240min, and remained elevated after 960min. The apparent elimination half-life was 3·93h, and the maximum plasma concentration was 666 (sem 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.

Keywords

AlkylresorcinolsBiomarkersWholegrain cerealsRye
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 282 - 287
Copyright
Copyright © The Nutrition Society 2006

References

Bach Knudsen, KE, Canibe, N & Jørgensen, HQuantification of the absorption of nutrients deriving from carbohydrate assimilation: model experiment with catheterised pigs fed on wheat and oat based rolls. Br J Nutr. (2000) 84 449–458CrossRefGoogle ScholarPubMed
Bach Knudsen, KE, Serena, A, Bjørnbak, Kjaer AK, Tetens, I, Heinonen, S-M, Nurmi, T & Adlercreutz, HRye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces. J Nutr. (2003) 133 1368–1375CrossRefGoogle ScholarPubMed
Bingham, SA, Luben, R, Welch, A, Wareham, N, Khaw, KT & Day, NAre imprecise methods obscuring a relation between fat and breast cancer?. Lancet. (2003) 362 212–214CrossRefGoogle ScholarPubMed
Branca, F, Hanley, AB, Pool-Zobel, B & Verhagen, HBiomarkers in disease and health. Br J Nutr. (2001) 85 S55–S92CrossRefGoogle Scholar
Chen, Y, Ross, AB, Åman, P & Kamal-Eldin, AAlkylresorcinols as markers of whole-grain wheat and rye in cereal products. J Agric Food Chem. (2004) 52 8242–8246CrossRefGoogle ScholarPubMed
Hallmans, G, Zhang, J-X, Lundin, E, Stattin, P, Johansson, A, Johansson, I, Hultén, K, Winkvist, A, Lenner, P, Åman, P & Adlercreutz, HRye, lignans and human health. Proc Nutr Soc. 62. (2003) 193–199CrossRefGoogle ScholarPubMed
Jensen, MK, Koh-Banerjee, P, Hu, FB, Franz, MSampson, LGrønbæk, M & Rimm, EBIntakes of whole grains, bran, and germ and the risk of coronary heart disease in men. Am J Clin Nutr. (2004) 80 1492–1499CrossRefGoogle ScholarPubMed
Kantor, LS, Variyam, JN, Allshouse, JE, Putnam, JJ & Lin, B-HChoose a variety of grains daily, especially whole grains: a challenge for consumers. J Nutr. (2001) 131 473S–486SCrossRefGoogle ScholarPubMed
Kozubek, A & Tyman, JHPResorcinolic lipids, the natural non-isoprenoid phenolic amphiphiles and their biological activity. Chem Rev. (1999) 99 1–25CrossRefGoogle ScholarPubMed
Lee-Kim, YC, Meydani, M, Kassarjian, Z, Blumberg, JB & Russell, RMEnterohepatic circulation of newly administered α-tocopherol in the rat. Int J Vitam Nutr Res. (1988) 58 284–291Google ScholarPubMed
Levi, F, Pasche, C, Lucchini, F, Chatenoud, L, Jacobs, DRJ & La Vecchia, CRefined and whole-grain cereals and the risk of oral, oesophageal and laryngeal cancer.Eur J Clin Nutr. (2000) 54 487–489CrossRefGoogle ScholarPubMed
Linko, A-M & Adlercreutz, HWhole grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes. Br J Nutr (2005) 93 11–13CrossRefGoogle ScholarPubMed
Linko, A-M, Juntunen, KS, Mykkänen, HM & Adlercreutz, HWhole-grain rye bread consumption by women correlates with plasma alkylresorcinols and increases their concentration compared with low-fiber wheat bread.J Nutr. (2005) 135 580–583CrossRefGoogle ScholarPubMed
Linko, A-M, Parikka, KWähälä, K & Adlercreutz, HGas chromatographic - mass spectrometric method for the determination of alkylresorcinols in human plasma. Anal Biochem. (2002) 308 307–313CrossRefGoogle ScholarPubMed
Rérat, AAIntestinal absorption of end products from digestion of carbohydrates and proteins in the pig.Archiv Tierernährung.(1985) 35 461–480CrossRefGoogle ScholarPubMed
Rérat, AA, Vaissade, P & Vaugelade, PAbsorption kinetics of some carbohydrates in conscious pigs. 2. Quantitative aspects. Br J Nutr. (1984) 51 517–529CrossRefGoogle ScholarPubMed
Ross, AB, Åman, P, Andersson, R & Kamal-Eldin, AChromatographic analysis of alkylresorcinols and their metabolites. J Chromatogr. (2004a) 1054 157–164CrossRefGoogle ScholarPubMed
Ross, AB, Åman, P & Kamal-Eldin, AIdentification of cereal alkylresorcinol metabolites in human urine-potential biomarkers of wholegrain wheat and rye intake. J Chromatogr. (2004b) 809 125–130Google ScholarPubMed
Ross, AB, Becker, W, Chen, Y, Kamal-Eldin, A & Åman, PIntake of alkylresorcinols from wheat and rye in the United Kingdom and Sweden. Br J Nutr. (2005) 94 496–499CrossRefGoogle ScholarPubMed
Ross, AB, Chen, Y, Frank, J, Swanson, JE, Parker, RS, Kozubek, A, Lundh, T, Vessby, B, Åman, P & Kamal-Eldin, ACereal alkylresorcinols elevate g-tocopherol levels in rats and inhibit g-tocopherol metabolism in vitro.J Nutr. (2004c) 134 506–510Google Scholar
Ross, AB, Kamal-Eldin, A & Åman, PDietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods. Nutr Rev. (2004d) 62 81–95CrossRefGoogle ScholarPubMed
Ross, AB, Kamal-Eldin, A, Jung, C, Shepherd, MJ & Åman, PGas chromatographic analysis of alkylresorcinols in rye ( Secale cereale L) grains. J Sci Food Agric. (2001) 81 1405–1411CrossRefGoogle Scholar
Ross, AB, Kamal-Eldin, A, Lundin, EA, Zhang, JX, Hallmans, G & Åman, PCereal alkylresorcinols are absorbed by humans. J Nutr. (2003a) 133 2222–2224CrossRefGoogle ScholarPubMed
Ross, AB, Shepherd, MJ, Bach, Knudsen KE, Glitsø, LV, Bowey, E, Phillips, J, Rowland, I, Guo, Z-X, Massy, DJR, Åman, P & Kamal-Eldin, AAbsorption of dietary alkylresorcinols in ileal-cannulated pigs and rats. Br J Nutr. (2003b) 90 787–794CrossRefGoogle Scholar
Ross, AB, Shepherd, MJ, Schüpphaus, M, Sinclair, V, Alfaro, B, Kamal-Eldin, A & Åman, PAlkylresorcinols in cereals and cereal products. J Agric Food Chem (2003c) 51 4111–4118CrossRefGoogle ScholarPubMed
Schwedhelm, E, Maas, R, Troost, R & Böger, RHClinical pharmacokinetics of antioxidants and their importance on systemic oxidative stress. Clin Pharmacokinet. (2003) 42 437–459CrossRefGoogle Scholar
Slavin, JL, Jacobs, D, Marquart, L & Wiemer, KThe role of whole grains in disease prevention. J Am Diet Assoc. (2001) 101 780–785CrossRefGoogle ScholarPubMed
Traber, MGThe bioavailability bugaboo. Am J Clin Nutr. (2000) 71 1029–1030CrossRefGoogle ScholarPubMed
Truswell, ASCereal grains and coronary heart disease. Eur J Clin Nutr (2002) 56 1–14CrossRefGoogle ScholarPubMed
van der, Meulen JBakker, JGSmits, B & de Visser, HEffects of source of starch on net portal flux of glucose, lactate, volatile fatty acids and amino acids in the pig.Br J Nutr.(1987) 78 533–544CrossRefGoogle Scholar
Yap, SP, Yuen, KH & Wong, JWPharmacokinetics and bioavailability of a-, g- and d-tocotrienols under different food status. Pharmaceutical Press. (2004) 53 67–71Google Scholar