Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-24T05:04:51.288Z Has data issue: false hasContentIssue false
  • English
  • Français

Iron nutrition and anaemia in a malaria-endemic environment: haematological investigation of the Gidra-speaking population in lowland Papua New Guinea

Published online by Cambridge University Press:  09 March 2007

Minato Nakazawa ,
Ryutaro Ohtsuka ,
Toshio Kawabe ,
Tetsuro Hongo ,
Tsukasa Inaoka ,
Tomoya Akimichi  and
Tsuguyoshi Suzuki
Minato Nakazawa
Affiliation:
Department of Human Ecology, Faculty of Medicine, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113 Japan
Ryutaro Ohtsuka
Affiliation:
Department of Human Ecology, Faculty of Medicine, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113 Japan
Toshio Kawabe
Affiliation:
Takasaki City University of Economics, Takasaki, Gunma, 370 Japan
Tetsuro Hongo
Affiliation:
Department of Human Ecology, Faculty of Medicine, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113 Japan
Tsukasa Inaoka
Affiliation:
Department of Public Health, Kumamoto University Medical School, Kumamoto, 860 Japan
Tomoya Akimichi
Affiliation:
National Museum of Ethnology, Osaka, 565 Japan
Tsuguyoshi Suzuki
Affiliation:
National Institute for Environmental Studies, Tsukuba, Ibaraki, 305 Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Blood examination was conducted for the four Gidra-speaking village groups in Papua New Guinea, who were characterized by high Fe intake and high malaria prevalence with marked inter-village differences. The northern riverine villagers, whose Fe intake was higher than the other three village groups, did not suffer from Fe-deficiency anaemia in their malaria-endemic environment; nor did the inland villagers, with their second highest Fe intake and their malaria-free environment, suffer from Fe-deficiency anaemia. However, several individuals of the southern riverine village suffered from anaemia in a malaria-endemic environment, although their Fe intake was almost the same as the inland villagers’. A considerable proportion of the coastal villagers were anaemic, reflecting the lowest Fe intake and the highest malaria prevalence. An inter-village comparison of the relationships between haemoglobiin levels and transferrin saturation revealed that the southern riverine villagers needed smaller amounts of circulating Fe for erythropoiesis than the northern riverine and inland villagers, reflecting the long-term human-environment conditions such as the density of malaria vectors and the people’s dietary habits. Fe supplementation was not judged effective against hypoferraemia and/or anaemia in such a population. As the incidence of malaria had no significant long-lasting effect on Fe stores or circulating Fe concentration, but did have an effect on anaemia, the hypothesis that malaria causes a transfer of Fe from the blood to parenchymal tissues as a defence against infectious diseases was not supported.

Keywords

IronAnaemiaMalaria
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 3 , September 1996 , pp. 333 - 346
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

Abdalla, S., Weatherall, D. J., Wickramasinghe, S. N. & Hughes, M. (1980). The anaemia of P. falciparum malaria. British Journal of Haematology 46, 171–183.Google Scholar
Adelekan, D. A. & Thurnham, D. I. (1990). Plasma ferritin concentrations in anemic children: relative importance of malaria, riboflavin deficiency, and other infections. American Journal of Clinical Nutrition 51, 454–456.CrossRefGoogle ScholarPubMed
Cook, J. D., Lipschitz, D. A., Miles, L. E. M. & Finch, C. A. (1974). Serum ferritin as a measure of iron stores in normal subjects. American Journal of Clinical Nutrition 27, 681–687.CrossRefGoogle ScholarPubMed
DeMaeyer, E. M. (1989). Preventing and Controlling Iron Deficiency Anaemia Through Primary Health Care. A Guide for Health Administrators and Programme Managers. Geneva: WHO.Google Scholar
Edwards, C. Q., Griffen, L. M., Kaplan, J. & Kushner, J. P. (1989). Twenty-four hours variation of transferrin saturation in treated and untreated haemochromatosis homozygotes. Journal of lnternal Medicine 226, 373–379.CrossRefGoogle Scholar
Expert Scientific Working Group (1985). Summary of a report on assessment of the iron nutritional status of the United States population. American Journal of Clinical Nutrition 42, 1318–1330.CrossRefGoogle Scholar
Garruto, R. M., Yanagihara, R. & Gajdusek, D. C. (1988). Cycads and amyotrophic lateral sclerosis/ Parkinsonism dementia. Lancet 2, 1079.Google Scholar
Goh, T. H. & Hariharan, M. (1986). Iron-deficiency anaemia and serum ferritin levels in Malaysian women. Medical Journal of Malaysia 41, 300–304.Google ScholarPubMed
Guindi, M. E., Skikne, B. S., Covell, A. M. & Cook, J. D. (1988). An immunoassay for human transferrin. American Journal of Clinical Nutrition 47, 37–41.Google ScholarPubMed
Hercberg, S., Galan, P. & Dupin, H. (1987). Iron deficiency in Africa. World Review of Nutrition and Dietetics 54, 201–236.CrossRefGoogle ScholarPubMed
Hongo, T., Suzuki, T., Ohtsuka, R., Kawabe, T., Inaoka, T. & Akimichi, T. (1989 a). Compositional character of Papuan foods. Ecology of Food and Nutrition 23, 39–56.Google Scholar
Hongo, T., Suzuki, T., Ohtsuka, R., Kawabe, T., Inaoka, T. & Akimichi, T. (1989 b). Element intake of the Gidra in lowland Papua: inter-village variation and the comparison with contemporary levels in developed countries. Ecology of Food and Nutrition 23, 293–309.CrossRefGoogle Scholar
Katz, S. H. (1987). Food and biocultural evolution: a model for the investigation of modern nutritional problems. In Nutritional Anthropology, pp. 41–63 [Johnston, F. E. editor]. New York: Alan R. Liss Inc.Google Scholar
Kent, S. (1992). Anemia through the ages: changing perspectives and their implications. Diet, Demography, and Disease: Changing Perspectives on Anemia, pp. 1–30 [Stuart-Macadam, P. and Kent, S. editors]. New York: Aldine de Gruyter.Google Scholar
Kent, S. & Dunn, D. (1993). Etiology of hypoferremia in a recently sedentary Kalahari village. American Journal of Tropical Medicine and Hygiene 48, 554–567.Google Scholar
Kumar, N., Bhargava, M., Sundaram, K. R., Kumar, S., Bhargava, V. L. & Kumar, R. (1989). Serum ferritin as a measure of iron stores in normal Indian subjects and pregnant women. Nutrition Research 9, 999–1006.CrossRefGoogle Scholar
Milman, N., Pedersen, N. S. & Visfeldt, J. (1983). Serum ferritin in healthy Danes: relation to marrow haemosiderin iron stores. Danish Medical Bulletin 30, 115–120.Google Scholar
Murray, M. J., Murray, A. B., Murray, N. J. & Murray, M. B. (1975). Refeeding-malaria and hyperferraemia. Lancet 1, 653–654.CrossRefGoogle ScholarPubMed
Nakazawa, M., Ohtsuka, R., Kawabe, T., Hongo, T., Suzuki, T., Inaoka, T., Akimichi, T., Kano, S. & Suzuki, M. (1994). Differential malaria prevalence among villages of the Gidra in lowland Papua New Guinea. Tropical and Geographical Medicine 46, 350–354.Google Scholar
Ohtsuka, R., Inaoka, T., Kawabe, T., Suzuki, T., Hongo, T. & Akimichi, T. (1985). Diversity and change of food consumption and nutrient intake among the Gidra in lowland Papua. Ecology of Food and Nutrition 16, 339–350.CrossRefGoogle Scholar
Ohtsuka, R. & Suzuki, T. (Eds.) (1990). Population Ecology of Human Survival. Bioecological Studies of the Gidra in Papua New Guinea. Tokyo: University of Tokyo Press.Google Scholar
Oppenheimer, S. J., Gibson, F. D., Macfarlane, S. B., Moody, J. B., Harrison, C., Spencer, A. & Bunari, O. (1986). Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 603–612.Google Scholar
Oppenheimer, S. J., Gibson, F. D., Macfarlane, S. B., Moody, J. B. & Hendrickse, R. G. (1984). Iron supplementation and malaria. Lancet 1, 388–390.Google ScholarPubMed
Pippard, M. J. (1990). Iron deficiency and overload. In Oxford Textbook of Medicine, pp. 19.83–19.91. Oxford: Oxford University Press.Google Scholar
Statistical Analysis Systems Institute (1982 a). SAS Users' Guide; Basics, 4th ed. Cary, NC: SAS Institute Inc.Google Scholar
Statistical Analysis Systems Institute (1982 b). SAS Users' Guide: Statistics, 4th ed. Cary, NC: SAS Institute Inc.Google Scholar
Wadsworth, G. R. (1992). Physiological, pathological, and dietary influences on the hemoglobin level. Diet, Demography, and Disease: Changing Perspectives on Anemia, pp. 63–104 [Stuart-Macadam, P. and Kent, S. editors]. New York: Aldine de Gruyter.Google Scholar
Weinberg, E. D. (1992). Iron withholding in prevention of disease. In Diet, Demography, and Disease: Changing Perspectives on Anemia, pp. 105–150 [Stuart-Macadam, P. and Kent, S. editors]. New York: Aldine de Gruyter.Google Scholar
Wick, M., Pinggera, W. & Lehmann, P. (1991). Ferritin in Iron Metabolism: Diagnostic Strategies. Wien: Springer-Verlag.CrossRefGoogle Scholar
Wickramasingle, S. N., Gill, D. S., Broom, G. N., Akinyanju, O. O. & George, A. (1985). Limited value of serum ferritin in evaluating iron status in children with protein-energy malnutrition. Scandinuvian Journal of Haematology 35, 292–298.Google Scholar
Woodruff, A. W., Ansdell, V. E. & Pettitt, L. E. (1979). Cause of anaemia in malaria. Lancet 1, 1055–1057.CrossRefGoogle ScholarPubMed
World Health Organization (1972). Nutritional Anaemias. Report of a WHO Group of Experts. WHO Technical Report Series no. 503. Geneva: WHO.Google Scholar
World Health Organization (1975). Control of Nutritional Anaemia with Special Reference to Iron Deficiency. Report of an IAEA/IUSAID/WHO Joint Meeting. WHO Technical Report Series no. 580.Geneva:WHO.Google Scholar