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Iron, copper and zinc status in rats fed on diets containing various concentrations of tin

Published online by Cambridge University Press:  09 March 2007

H. L. M. Pekelharing ,
A. G. Lemmens  and
A. C. Beynen
H. L. M. Pekelharing
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EVWageningen, The Netherlands
A. G. Lemmens
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EVWageningen, The Netherlands
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Abstract

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The effects of various dietary concentrations of Sn (1, 10, 50, 100 and 200 mg/kg; added as SnCl2) on Fe, Cu and Zn status of rats were determined. After feeding the diets for 28 d body weight was not significantly affected, but there was a Linear inverse response of feed intake. Plasma, kidney, spleen and tibia Fe concentrations as well as blood haemoglobin concentration and percentage transferrin saturation decreased in a linear dose-response manner as the level of dietary Sn increased. The addition of Sn to the diet depressed Cu status, as indicated by a significant inverse response of plasma, Liver, kidney, spleen and tibia Cu levels. Plasma, kidney and tibia Zn concentrations were decreased by increasing levels of dietary Sn, but spleen and Liver Zn concentrations were not significantly influenced. Fe, Cu and Zn status was influenced by dietary Sn concentrations lower than 50 mg/kg. If the results can be extrapolated to man it would follow that a high v. low Sn concentration in the human diet, which can be as distinct as 75 v. 2 mg/kg dry diet, may decrease plasma and tissue concentrations of Fe, Cu and Zn by up to 15%.

Keywords

TinIronCopperZincRat
Type
Interactions between tin and minerals
Information
British Journal of Nutrition , Volume 71 , Issue 1 , January 1994 , pp. 103 - 109
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Becker, G., Huebers, H. & Runimel, W. (1979). Intestinal absorption of cobalt and iron: Mode ofinteraction and subcellular distribution. Blut 38, 397–406.Google Scholar
De Groot, A. P. (1973). Subacute toxicity of inorganic tin as influenced by dietary levels of iron and copper. Food and Cosmetics Toxicology 11, 955–962.Google Scholar
De Groot, A. P., Feron, V. J. & Til, H. P. (1973). Short-term toxicity studies on some salts and oxides of tin in rats. Food and Cosmetics Toxicology 11, 19–30.CrossRefGoogle ScholarPubMed
Greger, J. L. & Baier, M. (1981). Tin and iron content of canned and bottled foods. Journal of Food Science 46, 1751–1765.Google Scholar
Greger, J. L. & Johnson, M. A. (1981). Effect of dietary tin on zinc, copper and iron utilization by rats. Food and Cosmetics Toxicology 19, 163–166.Google Scholar
Johnson, M. A. & Greger, J. L. (1984). Absorption, distribution and endogenous excretion of zinc by rats fed various dietary levels of inorganic tin and zinc. Journal of Nutrition 114, 1843–1852.Google Scholar
Johnson, M. A. & Greger, J. L. (1985). Tin, copper, iron and calcium metabolism of rats fed various dietary levels of inorganic tin and zinc. Journal of Nutrition 115, 615–624.Google Scholar
Morris, E. R. (1987). Iron. In Trace Elements in Human and Animal Nutrition, Vol. 1, pp. 79–142 [Mertz, W., editor]. San Diego, CA: Academic Press, Inc.CrossRefGoogle Scholar
National Research Council (1978). Nutrient Requirements of Laboratory Animals, 3rd ed. Washington, DC: National Academy of Sciences.Google Scholar
Schäfer, S. G. & Forth, W. (1983). The influence of tin, nickel and cadmium on the intestinal absorption of iron. Ecotoxicology and Environmental Safety 7, 87–95.CrossRefGoogle Scholar
SPSS Inc. (1988). SPSS/PC+TM V2.0 Base Manual, Chicago, IL: SPSS Inc.Google Scholar
Yamaguchi, M., Kitade, M. & Okada, S. (1980 a). The oral administration of stannous chloride to rats. Toxicology Letters 5, 275–278.Google Scholar
Yamaguchi, M., Saito, R. & Okada, S. (1980 b). Dose-effect of inorganic tin on biochemical indices in rats. Toxicology 16, 267–273.Google Scholar