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Inulin/oligofructose and anticancer therapy

Published online by Cambridge University Press:  09 March 2007

H. S. Taper  and
M. B. Roberfroid
H. S. Taper*
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, PMNT 73.69, Avenue Em. Mounier, 73, B – 1200 Bruxelles, Belgium
M. B. Roberfroid
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, PMNT 73.69, Avenue Em. Mounier, 73, B – 1200 Bruxelles, Belgium
*
*Corresponding author: Dr H. S. Taper, Tel.: +32 2 764 73 69, fax: +32 2 764 73 59, email [email protected]
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Abstract

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The results of our investigations indicate that dietary treatment with inulin or oligofructose incorporated in the basal diet for experimental animals: (i) reduced the incidence of mammary tumors induced in Sprague-Dawley rats by methylnitrosourea; (ii) inhibited the growth of transplantable malignant tumors in mice; and (iii) decreased the incidence of lung metastases of a malignant tumor implanted intramuscularily in mice. Moreover, besides such cancer risk reduction effects, the dietary treatment with inulin or oligofructose significantly potentiated the effects of subtherapeutic doses of six different cytotoxic drugs commonly utilized in human cancer treatment. If confirmed, such dietary treatment with inulin or oligofructose potentiating cancer therapy might become an interesting approach to complement classical protocols of human cancer treatment without any additional risk for the patients.

Keywords

Inulin/oligofructoseAnticancer therapy
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S283 - S286
Copyright
Copyright © The Nutrition Society 2002

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