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Inulin and oligofructose: effects on lipid metabolism from human studies

Published online by Cambridge University Press:  09 March 2007

C. M. Williams  and
K. G. Jackson
C. M. Williams*
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, The University of Reading, Reading RG6 6AP, UK
K. G. Jackson
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, The University of Reading, Reading RG6 6AP, UK
*
*Corresponding author: Professor C M Williams, tel +44 0118 9318706, fax +44 0118 9310080, email [email protected]
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Abstract

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Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.

Keywords

TriglyceridemiaInulinemiaInulinOligofructose
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S261 - S264
Copyright
Copyright © The Nutrition Society 2002

References

Aarsland, A, Chinkes, D & Wolfe, RR (1996) Contributions of de novo synthesis of fatty acids to total VLDL-triacylglycerol secretion during prolonged hyperglycemial hyperinsulinemia in normal man. Journal of Clinical Investigation 98, 2008–2017.CrossRefGoogle Scholar
Alles, MA, de Roos, NM, Bakz, JC, van de Lisdonk, E, Zock, PL & Hautvast, JGAJ (1999) Consumption of fructo-oligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. American Journal of Clinical Nutrition 69, 64–69.CrossRefGoogle Scholar
Brighenti, F, Casiraghi, MC, Canzi, E & Ferrari, A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. European Journal of Clinical Nutrition 53, 726–733.CrossRefGoogle ScholarPubMed
Causey, JL, Feirtag, JM, Gallaher, DD, Tungland, BC & Slavin, JL (2000) Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men. Nutrition Research 20, 191–201.CrossRefGoogle Scholar
Davidson, MH, Synecki, C, Maki, KC & Drennan, KB (1998) Effects of dietary inulin in serum lipids in men and women with hypercholesterolemia. Nutrition Research 3, 503–517.CrossRefGoogle Scholar
Delzenne, N, Kok, N, Fiordaliso, M, Deboyser, D, Goethals, F & Roberfroid, M (1993) Dietary fructo-oligosaecharides modifies lipid metabolism in rats. American Journal of Clinical Nutrition 57, 8205.CrossRefGoogle Scholar
Fiordaliso, MF, Kok, N, Desager, JP, Goethals, F, Deboyser, D, Roberfroid, M & Delzenne, N (1995) Dietary oligofructose lowers triacylglycerols, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167.CrossRefGoogle ScholarPubMed
Griffin, BA, Freeman, DJ, Tait, GW, Thomson, J, Caslake, MJ, Packard, CJ & Shepherd, J (1994) Role of plasma triglyceride in the regulation of plasma LDL subfractions: relative contribution of small dense LDL to coronary heart disease risk. Atherosclerosis 106, 241–253.CrossRefGoogle ScholarPubMed
Hidaka, H, Tashiro, Y & Eida, T (1991) Proliferation of bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobacteria Microflora 10, 65–79.CrossRefGoogle Scholar
Jackson, KG, Taylor, GRJ, Clohessy, AM & Williams, CM (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. British Journal of Nutrition 82, 23–30.CrossRefGoogle ScholarPubMed
Kok, N, Roberfroid, M & Delzenne, N (1996 a) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition 76, 881–890.CrossRefGoogle ScholarPubMed
Kok, N, Roberfroid, M & Deizenne, N (1996 b) Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism 45, 1547–1550.CrossRefGoogle ScholarPubMed
Luo, J, Rizkalla, SW, Alamowitch, C, Boussairi, A, Blayo, A, Barry, J-L, Laffifle, A, Ouyon, F, Bornet, FRJ & Slama, VS (1996) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. American Journal of Clinical Nutrition 63, 939–945.CrossRefGoogle ScholarPubMed
Parks, E (2002) Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentration. British Journal of Nutrition 87, S247–S253, this issue.CrossRefGoogle Scholar
Pedersen, A, Sandstrom, B & Van Amelsvobrt, JMM (1997) The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. British Journal of Nutrition 78, 215–222.CrossRefGoogle ScholarPubMed
Roberfroid, M (1993) Dietary fiber, inulin and oligofructose: a review comparing their physiological effects. Critical Reviews in Food Science and Nutrition 33, 102–148.CrossRefGoogle ScholarPubMed
Todesco, T, Rao, AV, Bosello, O & Jenkins, DJA (1991) Propionate lowers blood glucose and alters lipid metabolism in healthy subjects. American Journal of Clinical Nutrition 54, 860–865.CrossRefGoogle ScholarPubMed
Wolever, TMS, Spadafora, PJ, Cunnane, SC & Pencharz, PB (1995) Propionate inhibits incorporation of colonic [1,2-13C] acetate into plasma lipids in humans. American Journal of Clinical Nutrition 61, 1241–1247.CrossRefGoogle ScholarPubMed
Williams, CM (1997) Postprandial lipid metabolism: effects of dietary fatty acids. Proceedings of the Nutrition Society 6, 679–692.CrossRefGoogle Scholar
Yamashita, K, Kawai, K & Itakura, M (1984) Effectsof fructo-oligosaccharides on blood glucose and serum lipids in diabetic subjects. Nutrition Research 4, 961–966.CrossRefGoogle Scholar