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Intussusception in the Syrian Golden hamster

Published online by Cambridge University Press:  09 March 2007

Stephen C. Cunnane  and
Stephen R. Bloom
Stephen C. Cunnane
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Stephen R. Bloom
Affiliation:
Royal Postgraduate Medical School, Hammersmith Hospital, DuCane Road, London W12 OHS
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Abstract

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Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production. Plasma levels of gastric inhibitory polypeptide (GIP) were reduced 80% (P < 0.01) but peptide tyrosine/tyrosine and enteroglucagon in plasma were increased 290 and 526 % respectively in hamsters with intussusception. Variations in dietary fatty acid composition had no effect but intussusception was not observed after changing the dietary carbohydrate from sucrose to starch.

Colon: Cystic fibrosis: Intussusception: Peptide hormones: Hamster

Keywords

ColonCystic fibrosisIntussusceptionPeptide hormonesHamster
Type
Digestion, Absorption and Gut Physiology
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 231 - 237
Copyright
Copyright © The Nutrition Society 1990

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