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Intravenous administration of thiomolybdate for the prevention and treatment of chronic copper poisoning in sheep

Published online by Cambridge University Press:  09 March 2007

S. R. Gooneratne ,
J. McC Howell  and
J. M. Gawthorne
S. R. Gooneratne
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
J. McC Howell
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
J. M. Gawthorne
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
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Abstract

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1. Twenty-six sheep were used in experiments designed to test the effectiveness of ammonium tetrathiomolybdate in the prevention and treatment of chronic copper poisoning.

2. Intravenous injections of 100 mg ammonium tetrathiomolybdate twice weekly (a) prevented the occurrence of haemolytic crisis in sheep repeatedly dosed with copper sulphate and (b) minimized tissue damage and prevented further haemolytic crisis when given to sheep already in haemolysis.

3. Thiomolybdate prevented excessive depostion of Cu in the liver of sheep receiving orally large amounts of Cu and decreased liver Cu levels in sheep that were not given additional Cu. In the latter sheep, 50 mg ammonium tetrathiomolybdate given twice weekly did not produce histologically-detectable tissue damage even though liver and kidneys contained high levels of molybdenum, and kidneys contained elevated levels of Cu.

4. It is concluded that chronic Cu poisoning can be successfully prevented or treated by intravenous injection of appropriate doses of ammonium tetrathiomolybdate.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 46 , Issue 3 , November 1981 , pp. 457 - 467
Copyright
Copyright © The Nutrition Society 1981

References

Allcroft, R. & Lewis, G. (1956). Landbouwk. Tijdschv 68, 711.Google Scholar
Aymonino, P. J., Ranade, A. C. & Müller, A. (1969). Z. anorg. allg. Chem. 371, 295.CrossRefGoogle Scholar
Bell, M. C., Diggs, B. G., Lowrey, R. S. & Wright, P. L. (1964). J. Nutr. 84, 367.CrossRefGoogle Scholar
Bremner, I. & Young, B. W. (1978). Br. J. Nutr. 39, 325.CrossRefGoogle Scholar
Brouwer, F., Frens, A. M., Reitsma, P. & Kalesvaart, C. (1938). Versl. landbouwk. Onderz. 44c, 267.Google Scholar
Dick, A. T., Dewey, D. W. & Gawthorne, J. M. (1975). J. agric. Sci., Camb. 85, 567.CrossRefGoogle Scholar
Fell, B. F., Dinsdale, D. & El-Gallad, T. (1979). J. Comp. Path. Ther. 89, 495.CrossRefGoogle Scholar
Ferguson, W. S., Lewis, A. H. & Watson, S. J. (1938). Nature, Lond. 141, 553.CrossRefGoogle Scholar
Ferguson, W. S., Lewis, A. H. & Watson, S. J. (1943). J. agric. Sci., Camb. 33, 44.CrossRefGoogle Scholar
Ford, E. J. H. (1967). J. Comp. Path. Ther. 77, 405.CrossRefGoogle Scholar
Gooneratne, S. R. (1979). Morphometric, electron microscopic, biochemical and pathological investigation of liver of normal and copper poisoned sheep. PhD Thesis, Murdoch University, Western Australia.Google Scholar
Gooneratne, S. R., Howell, J. McC. & Gawthorne, J. M. (1979). Res. vet. Sci. 27, 30.CrossRefGoogle Scholar
Gooneratne, S. R., Howell, J. McC. & Gawthorne, J. M. (1981). Br. J. Nutr. 46, 469.CrossRefGoogle Scholar
Gopinath, C., Hall, G. A. & Howell, J. McC. (1974). Res. vet. Sci. 16, 57.CrossRefGoogle Scholar
Gopinath, C. & Howell, J. McC. (1975). Res. vet. Sci. 19, 35.CrossRefGoogle Scholar
Hogan, K. G., Money, D. F. L. & Blayney, A. (1968). N.Z. Jl agric. Res. 11, 435.CrossRefGoogle Scholar
Ishmael, J., Gopinath, C. & Howell, J. McC. (1972). Res. vet. Sci. 13, 22.CrossRefGoogle Scholar
Kline, R. D., Hays, V. W. & Cromwell, G. L. (1971). J. Anim. Sci. 33, 771.CrossRefGoogle Scholar
Marcilese, N. A., Ammerman, C. B., Valsecchi, R. M., Dunavant, B. F. & Davis, G. K. (1970). J. Nutr. 100, 1399.CrossRefGoogle Scholar
Miller, J. K., Moss, B. R., Bell, M. C. & Snead, N. N. (1972). J. Anim. Sci. 34, 846.CrossRefGoogle Scholar
Norheim, G. & Waasjo, E. (1977). Z. Analyt. Chem. 286, 229.CrossRefGoogle Scholar
Ross, D. B. (1966). Br. vet. J. 122, 279.CrossRefGoogle Scholar
Schalm, O. W., Jain, N. C. & Carroll, E. J. (1975). Veterinary Haematology, 3rd edn, p. 76. Philadelphia: Lea and Fabiger.Google Scholar
Smith, B. S. W., Field, A. C. & Suttle, N. F. (1968). J. Comp. Path. Ther. 78, 449.CrossRefGoogle Scholar
Spence, J. A., Suttle, N. F., Wenham, G., El-Gallad, T. & Bremner, I. (1980). J. Comp. Path. Ther. 90, 139.CrossRefGoogle Scholar
Suttle, N. F. (1974). Proc. Nutr. Soc. 33, 299.CrossRefGoogle Scholar
Suttle, N. F. (1979). Proc. Nutr. Soc. 38, 58A.Google Scholar
Todd, J. R. (1962). Vet. Bull. 32, 573.Google Scholar
Todd, J. R. (1972). J. agric. Sci., Camb. 79, 191.CrossRefGoogle Scholar
Tridot, G. & Bernard, J. C. (1962). Acta Chim. hung. 34, 179.Google Scholar
Underwood, E. J. (1976). In The Proceedings of the International Symposium on Molybdenum in the Environment, vol. 1, p. 9 [Chappell, W. R. and Peterson, K. K. editors]. New York and Basel: Marcel and Dekker Inc.Google Scholar
Underwood, E. J. (1977). Trace Elements in Human and Animal Nutrition, 4th edn. p. 95. New York, San Francisco and London: Academic Press.Google Scholar
Ward, G. M. (1978). J. Anim. Sci. 46, 1078.CrossRefGoogle Scholar