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Intravenous administration of thiomolybdate for the prevention and treatment of chronic copper poisoning in sheep

Published online by Cambridge University Press:  09 March 2007

S. R. Gooneratne ,
J. McC Howell  and
J. M. Gawthorne
S. R. Gooneratne
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
J. McC Howell
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
J. M. Gawthorne
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia 6150, Australia
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Abstract

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1. Twenty-six sheep were used in experiments designed to test the effectiveness of ammonium tetrathiomolybdate in the prevention and treatment of chronic copper poisoning.

2. Intravenous injections of 100 mg ammonium tetrathiomolybdate twice weekly (a) prevented the occurrence of haemolytic crisis in sheep repeatedly dosed with copper sulphate and (b) minimized tissue damage and prevented further haemolytic crisis when given to sheep already in haemolysis.

3. Thiomolybdate prevented excessive depostion of Cu in the liver of sheep receiving orally large amounts of Cu and decreased liver Cu levels in sheep that were not given additional Cu. In the latter sheep, 50 mg ammonium tetrathiomolybdate given twice weekly did not produce histologically-detectable tissue damage even though liver and kidneys contained high levels of molybdenum, and kidneys contained elevated levels of Cu.

4. It is concluded that chronic Cu poisoning can be successfully prevented or treated by intravenous injection of appropriate doses of ammonium tetrathiomolybdate.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 46 , Issue 3 , November 1981 , pp. 457 - 467
Copyright
Copyright © The Nutrition Society 1981

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