Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-30T16:50:50.579Z Has data issue: false hasContentIssue false
  • English
  • Français

Intradialytic parenteral nutrition: comparison of olive oil versus soybean oilbasedlipid emulsions

Published online by Cambridge University Press:  08 March 2007

Noël J. M. Cano ,
Yannick Saingra ,
Anne-Marie Dupuy ,
Anne-Marie Lorec-Penet ,
Henri Portugal ,
Denis Lairon ,
Jean-Paul Cristol ,
Adrien Come ,
Alexia Le Brun  and
Philippe Atlan
...Show all authors
Noël J. M. Cano*
Affiliation:
Service d'Hépatogastroent´rologie et Nutrition, Clinique Résidence du Parc, Rue Gaston Berger, 13362, Marseille cedex 10, France
Yannick Saingra
Affiliation:
Service d'Hépatogastroent´rologie et Nutrition, Clinique Résidence du Parc, Rue Gaston Berger, 13362, Marseille cedex 10, France
Anne-Marie Dupuy
Affiliation:
Laboratorie de Biochimie, Hopital hapeyronie, 371 Avenue Doyen Gaston Gvaud, 34295 Montpellier, France
Anne-Marie Lorec-Penet
Affiliation:
Laboratoire central, CHU Sainte-Marguerite, Boulerard Sainte-Marguerite, 13009 Marseilles, France
Henri Portugal
Affiliation:
Laboratoire central, CHU Sainte-Marguerite, Boulerard Sainte-Marguerite, 13009 Marseilles, France
Denis Lairon
Affiliation:
UMR 476-INSERM/1260-INRA, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Jean-Paul Cristol
Affiliation:
Laboratorie de Biochimie, Hopital hapeyronie, 371 Avenue Doyen Gaston Gvaud, 34295 Montpellier, France
Adrien Come
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Alexia Le Brun
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Philippe Atlan
Affiliation:
Baxter SAS, 6 Avenue Louis Pasteur, BP 56, 7811 Maurepas, Cedex France
Xavier M. Leverve
Affiliation:
INSERM-E0221, Bioénergétique Fondamentale et Appliqueé, Université- BP 53XF Joseph Fourier, 38041 Grenoble, Cedex France
*
*Corresponding author:fax +33 4 91 83 88 38, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Lipid, oxidative and inflammatory parameters are frequently altered in dialysis patients and may be worsened by intravenous lipid emulsions (ILE). We assessed the efficacy and tolerance of olive as compared with standard soybean oil-based ILE during intradialytic parenteral nutrition (IDPN). IDPN mixtures containing amino acids, glucose, and either olive oil (OO group, n 17) or soybean oil-based ILE (SO group, n 18) were administered in a 5-week randomized, double-blind study. On days 0 and 35, patients' nutritional status was assessed by BMI, normalized protein catabolic rate, predialytic creatinine, serum albumin and transthyretin; lipid metabolism by plasma LDL- and HDL-cholesterol, triacylglycerols, phospholipids, apo A-I, A-II, B, C-II, C-III, E and lipoprotein (a); oxidative status by α-tocopherol, retinol, selenium, glutathione peroxidase, malondialdehyde and advanced oxidized protein products; inflammatory status by serum C-reactive protein, orosomucoid, IL-2 and IL-6. No serious adverse event was observed. Significant changes were observed from day 0 to day 35 (P<0·05): nutritional criteria improved (albumin in OO; albumin, transthyretin and creatinine in SO); LDL-cholesterol, apo B, C-II, C-III and apo A-I/A-II ratio increased in both groups. HDL-cholesterol decreased in OO; apo E increased and lipoprotein (a) decreased in SO; α-tocopherol/cholesterol ratio increased in OO; malondialdehyde decreased in both groups; IL-2 increased in both groups. The between-group comparison only showed the following differences: α-tocopherol/cholesterol increased in OO; lipoprotein (a) decreased in SO. From these data, it was concluded that OO- and SO-based IDPNs similarly improved nutritional status and influenced plasma lipid, oxidative, inflammatory and immune parameters.

Keywords

HaemodialysisIntradialytic parenteral nutritionFat emulsionsOlive oil
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 1 , January 2006 , pp. 152 - 159
Copyright
Copyright © The Nutrition Society 2006

References

Anstead, GM, Chandrasekar, B, Zhang, Q & Melby, PCMultinutrient undernutrition dysregulates the resident macrophage proin-flammatory cytokine network, nuclear factor-kappaB activation, and nitric oxide production. J Leukoc Biol (2003) 74 982 ndash; 991CrossRefGoogle Scholar
Attman, PO, Samuelsson, O, Johansson, AC, Moberly, JB & Alaupovic, PDialysis modalities and dyslipidemia. Kidney Int Suppl (2003) 63 110–112CrossRefGoogle Scholar
Bessler, H, Karp, L, Notti, I, Apter, A, Tyano, S, Djaldetti, M & Weizman, RCytokine production in anorexia nervosa. Clin Neuropharmacol (1993) 16 237–243CrossRefGoogle ScholarPubMed
Blondin, J & Ryan, CNutritional status: a continuous quality improvement approach. Am J Kidney Dis (1999) 33 198–202CrossRefGoogle ScholarPubMed
Cano, N, di Costanzo-Dufetel, J, Calaf, R, Durbec, JP, Lacombe, P, Pascal, S, Stroumza, P & Labastie-Coeyrehourq, JPrealbumin-retins-binding-protein-retinol complex in hemodialysis patients. Am J Clin Nutr (1988) 47 664–667CrossRefGoogle ScholarPubMed
Cano, N, Fernandez, JP, Lacombe, P, Lankester, M, Pascal, S, Defayolle, M, Labastie, J & Saingra, SStatistical selection of nutritional parameters in hemodialyzed patients. Kidney Int (1987) 32 supple 22 S178–S180Google Scholar
Cano, N, Labastie-Coeyrehourcq, J, Lacombe, P, Stroumza, P, di Costanzo-Dufetel, J, Durbec, JP, Coudray-Lucas, C & Cynober, LPerdialytic parenteral nutrition with lipids and amino-acids in malnourished hemodialysis patients. Am J Clin Nutr (1990) 52 726–730CrossRefGoogle ScholarPubMed
Cano, NLuc, G, Stroumza, PLacombe, P – Durbec, JPSerum lipoprotein changes after prolonged Intralipid® infusion in malnourished hemodialysis patients. Clin Nutr (1994) 13 111–115CrossRefGoogle Scholar
Capelli, JP, Kushner, H, Camiscioli, TC, Chen, SM & Torres, MAEffect of intradialytic parenteral nutrition on mortality rates in end-stage renal disease care. Am J Kidney Dis (1994) 23 808–816CrossRefGoogle ScholarPubMed
Chavance, M, Labarre, C, Bleiberg, F, Jacqueson, A, Ducimetiere, P, Lemonnier, D – Wade, SThyroxine-binding prealbumin, overnutrition and apolipoprotein A1.. Hum Nutr Clin Nutr (1986) 40 359–364Google ScholarPubMed
Chertow, GM, Ling, J, Lew, NL, Lazarus, JM & Lowrie, EGThe association of intradialytic parenteral nutrition administration with survival in hemodialysis patients. Am J Kidney Dis (1984) 24 912–920CrossRefGoogle Scholar
Choudhry, MA, Haque, FKhan, M, Fazal, NAl-Ghoul, WRavindranath, T, Gamelli, RL – Sayeed, MMEnteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in burn injury. Crit Care Med (2003) 31 1764–1770CrossRefGoogle ScholarPubMed
Combe, C, Chauveau, PLaville, M, Fouque, D, Azar, R, Cano, N, Canaud, B, Roth, H, Leverve, X & Aparicio, MInfluence of nutritional factors and hemodialysis adequacy on the survival of 1,610 French patients. Am J Kidney Dis (2001) 37 S81–S88CrossRefGoogle ScholarPubMed
Cristol, JP, Bosc, JY, Badiou, S, Leblanc, M, Lorrho, R, Descomps, B & Canaud, BErythropoietin and oxidative stress in haemodialysis:beneficial effects of vitamin E supplementation. Nephrol Dial Transplant (1997) 12 2312–2317CrossRefGoogle ScholarPubMed
Czekalski, S & Hozejowski, RIntradialytic amino acids supplementation in hemodialysis patients with malnutrition: results of a multicenter cohort study. J Ren Nutr (2004) 14 82–88CrossRefGoogle ScholarPubMed
Dasgupta, A, Kenny, MA, Ahmad, SAbnormal fatty acid pro-file in chronic hemodialysis patients: possible deficiency of essential fatty acids Clin Physiol Biochem (1990) 8 238–243Google Scholar
Duane, PD, Theahon, K & Crabtree, JEThe relationship between nutritional status and serum soluble interleukin-2 receptor concentrations in patients with Crohn's disease treated with elemental diet. Clin Nutr (1991) 10 222–227CrossRefGoogle ScholarPubMed
Foulks, CJThe effect of intradialytic parenteral nutrition on hospitalization rate and mortality in malnourished hemodialysis patients.. J Renal Nutr (1994) 4 5–10CrossRefGoogle Scholar
Friedewald, WT, Levy, RI & Frederickson, DSEstimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem (1972) 18 499–502CrossRefGoogle ScholarPubMed
Garred, LJ, Tang, W, Barichello, DL & Canaud, BEquations for the calculation of the protein catabolic rate from predialysis and post dialysis urea concentrations and residual renal clearance in stable hemodialysis patients. Blood Purif (1997) 15 157–168CrossRefGoogle Scholar
Goulet, O, de Potter, S, Antebi, H, Driss, F, Colomb, V, Bereziat, G, Alcindor, LG, Corriol, O, Le Brun, A, Dutot, G, Forget, D, Perennec, V & Ricour, CLong-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a doubleblind randomized study. Am J Clin Nutr (1999) 70 338–345CrossRefGoogle ScholarPubMed
Granato, D, Blum, S, Rossle, C, Le Boucher, J, Malnoe, A & Dutot, GEffects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr (2000) 24 113–118CrossRefGoogle ScholarPubMed
Heidland, A & Kult, JLong-term effects of essential amino acids supplementation in patients on regular dialysis treatment. Clin Nephrol (1975) 3 234–239Google ScholarPubMed
Held, PJ, Brunner, FOdaka, M, Garcia, JR, Port, FK & Gaylin, DSFive-year survival for end-stage renal disease patients in the United States, Europe, and Japan. Am J Kidney Dis (1990) 15 451–457CrossRefGoogle ScholarPubMed
Hiroshige, K, Iwamoto, M, Kabashima, N, Mutoh, Y, Yuu, K & Ohtan, AProlonged use of intradialysis parenteral nutrition in elderly malnourished chronic haemodialysis patients. Nephrol Dial Transplant 13, (1998) 13 2081–2087CrossRefGoogle ScholarPubMed
Hung, AM, Chertow, GM, Young, BS, Carey, S & Johansen, KLInflammatory markers are unrelated to physical activity, performance, and functioning in hemodialysis. Adv Ren Replace Ther (2003) 10 232–240CrossRefGoogle ScholarPubMed
Ikizler, TA, Wingard, RL, Harvell, J, Shyr, Y &Hakim, RMAssociation of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int (1999) 55 1945–1951CrossRefGoogle ScholarPubMed
Kaysen, GAThe microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol (2001) 12 1549–1557CrossRefGoogle Scholar
Kimmel, PL, Phillips, TM, Simmens, SJ, Peterson, RAKL, Weihs, KL, Alleyne, S, Cruz, I, Yanovski, JA & Veis, JHImmunologic function and survival in hemodialysis patient. Kidney Int (1998) 54 236–244CrossRefGoogle Scholar
Locatelli, F, Canaud, B, Eckardt, KU, Stenvinkel, P, Wanner, C & Zoccali, COxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant (2003) 18 1272–1280CrossRefGoogle ScholarPubMed
Madigan, KM, Olshan, A & Yingling, DJEffectiveness of intradialytic parenteral nutrition in diabetic patients with end-stage renal disease. J Am Diet Assoc (1990) 90 861–863CrossRefGoogle ScholarPubMed
McCann, L, Feldman, C, Hornberger, J, Belanger, S, Maru, L, Torres, M, Tootell, F & Gotch, FEffect of intradialytic parenteral nutrition on delivered Kt/V. Am J Kidney Dis (1999) 33 1131–1135CrossRefGoogle ScholarPubMed
Mortelmans, AK, Duym, P, Vandenbroucke, J, De Smet, R, Dhondt, A, Lesaffer, G, Verwimp, H & Vanholder, RIntradialytic parenteral nutrition in malnourished hemodialysis patients: a prospective long-term study. JPEN J Parenter Enteral Nutr (1999) 23 90–95CrossRefGoogle ScholarPubMed
Moussa, M, Le Boucher, J, Garcia, J, Tkaczuk, J, Ragab, J, Dutot, G, Ohayon, E, Ghisolfi, J & Thouvenot, JPIn vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr (2000) 19 49–54CrossRefGoogle ScholarPubMed
National Kidney Foundation Kidney disease outcomes quality initiative. Clinical practice guidelines for nutrition in chronic renal failure. I. Adult guidelines. A. Maintenance dialysis. Am J KidneyDis (2000) 35 suppl.2, S17–S55Google Scholar
Navarro, JF, Mora, C, Leon, C, Martin-Del Rio, R, Macia, ML, Gallego, E, Chahin, J, Mendez, ML, Rivero, A & Garcia, JAmino acid losses during hemodialysis with polyacrylonitrile membranes:effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients. Am J Clin Nutr (2000) 71 765–773CrossRefGoogle ScholarPubMed
Oguz, Y, Bulucu, F & Vural, AOral and parenteral essential amino acid therapy in malnourished hemodialysis patients. Nephron (2001) 89 224–227CrossRefGoogle ScholarPubMed
Ohnishi, H, Lin, KM & Chu, TMProlongation of serum half-life of interleukin 2 and augmentation of lymphokine-activated killer cell activity by pepstatin in mice. Cancer Res (1990) 50 1107–1112Google ScholarPubMed
Owen, WF, Lew, NL, Liu, Y, Lowrie, EG & Lazarus, JMThe urea reduction rate and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 329 1001–1006CrossRefGoogle ScholarPubMed
Paglia, DE & Valentine, WNStudies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med (1967) 70 158–169Google ScholarPubMed
Piraino, AJ, Firpo, JJ & Powers, DVProlonged hyperalimentation in catabolic chronic dialysis therapy patients. JPEN J Parenter Enteral Nutr (1981) 5 463–477CrossRefGoogle ScholarPubMed
Qureshi, AR, Alvestrand, A, Divino-Filho, JC, Gutierrez, A, Heimburger, O, Lindholm, B & Bergstrom, JInflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol (2002) 13 Suppl. 1, S28–S36CrossRefGoogle ScholarPubMed
Rosenthal, AJInterleukin-2, its receptor and nutrition in older adults: a review. J Nutr Health Aging (1999) 3 182–185Google ScholarPubMed
Savendahl, L & Underwood, LEDecreased interleukin-2 production from cultured peripheral blood mononuclear cells in human acute starvation. J Clin Endocrinol Metab (1997) 82 1177–1180Google ScholarPubMed
Schneeweiss, B, Graninger, W, Stockenhuber, F, Druml, W, Ferenci, P, Eichinger, S, Grimm, G, Laggner, AN & Lenz, KEnergy metabolism in acute and chronic renal failure. Am J Clin Nutr (1990) 52 596–601CrossRefGoogle ScholarPubMed
Schulman, G, Wingard, RLHutchison, RL, Lawrence, P & Hakim, RMThe effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis (1993) 21 527–534CrossRefGoogle ScholarPubMed
Siderova, VS, Carpentier, YADahlan, W & Richelle, MIntravascular metabolism of different fatty acids during lipid infusion in man. Clin Nutr (1993) 12 328–336CrossRefGoogle ScholarPubMed
Simopoulos, APOmega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr (1991) 54 438–463CrossRefGoogle ScholarPubMed
Smolle, KH, Kaufmann, P, Holzer, H & Druml, WIntradialytic parenteral nutrition in malnourished patients on chronic haemodialysis therapy. Nephrol Dial Transplant (1995) 10 1411–1416Google ScholarPubMed
Snyder, S, Bergen, C, Sigler, MH & Teehan, BPIntradialytic parenteral nutrition in chronic hemodialysis patients. ASAIO Trans (1919) 37 M373–M375Google Scholar
Toigo, G, Aparicio, M, Attman, P-O, Cano, N, Ciancaruso, D, Fouque, D, Heidland, A, Howard, P, Teplan, V & Guarnieri, GESPEN consensus on nutritional treatment of patients with renal insuffi-ciency (Part 2 of 2). Clin Nutr (2000) 19 281–291CrossRefGoogle Scholar
Walther, LE, Winnefeld, K & Solch, ODetermination of iron, copper, zinc, magnesium and selenium in plasma and erythrocytes in neurosurgical patients. J Trace Elem Med Biol (2000) 14 92–95CrossRefGoogle ScholarPubMed
Witko-Sarsat, V, Friedlander, M, Capeillere-Blandin, C, Nguyen-Khoa, T, Nguyen, AT, Zingraff, J, Jungers, P – Descamps-Latscha, BAdvanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int (1996) 49 1304–1313CrossRefGoogle ScholarPubMed
Wolfson, M &Foulks, CJIntradialytic parenteral nutrition: a useful therapy? Nutr Clin Pract (1996) 11 5–11CrossRefGoogle ScholarPubMed
Yagi, KA simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med (1976) 15 212–216CrossRefGoogle ScholarPubMed
Zwolinska, D, Medynska, ASzprynger, K & Szczepanska, MSerum concentration of IL-2, IL-6, TNF-alpha and their soluble receptors in children on maintenance hemodialysis. Nephron (2000) 86 441–446CrossRefGoogle ScholarPubMed