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Interaction between caffeine intake and heart zinc concentrations in the rat

Published online by Cambridge University Press:  09 March 2007

Magdalena J. Rossowska ,
Chantal Dinh ,
Sheila B. Gottschalk ,
Malektaj Yazdani ,
Fletcher S. Sutton III  and
Tetsuo Nakamoto
Magdalena J. Rossowska
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Chantal Dinh
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Sheila B. Gottschalk
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiologyand Pediatrics, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Malektaj Yazdani
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Fletcher S. Sutton III
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Tetsuo Nakamoto
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
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Abstract

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The purpose of the present study was to determine the levels of zinc in the hearts of growing post-weaning offspring, fetuses and their dams chronically fed caffeine. A further study was conducted to determine the distribution of Zn in subcellular heart fractions affected by acutely injecting caffeine into the veins of the adult rats. After delivery pups were raised on a 200 g protein/kg diet until day 22 of weaning. On day 22 randomly selected male offspring from each litter were divided into two groups. Group 1 was fed continuously on the same diet as a control, whereas in the experimental group offspring were fed on a 200 g protein/kg diet supplemented with caffeine (20 mg/kg). On day 49 the animals were killed and Zn, calcium and magnesium concentrations of the hearts were measured. In the second series of studies pregnant dams were randomly divided into two groups. Group 1 was fed on a 200 g protein/kg diet from day 3 of gestation, whereas in the experimental group dams were fed on the diet supplemented with caneme. On day 22 of gestation the fetuses were surgically removed. The Zn, Ca and Mg concentrations of hearts of fetuses and dams were determined. In the third phase a caffeine solution was injected into the vein. After 45 min the hearts were removed and Zn levels in the subcellular fractions determined. The hearts of the growing offspring fed on a caffeine-supplemented diet consistently showed decreased Zn and Ca levels compared with the non-caffeine group. In contrast, Zn and Ca concentrations of the hearts of fetuses and dams showed no difference between caffeine and non-caffeine groups. In the various fractions studied, the Zn contents affected by caffeine were in the supernatant (cytoplasmic) fraction. This fraction contained 30% of the Zn concentration of the homogenates. Current findings suggest that caffeine intake and heart Zn levels are closely correlated.

Keywords

CaffeineHeartZincRat
Type
Minerals: Absorption and Bioavailability
Information
British Journal of Nutrition , Volume 64 , Issue 2 , September 1990 , pp. 561 - 567
Copyright
Copyright © The Nutrition Society 1990

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