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Insight into the growth hormone–insulin-like growth factor-I axis in cancer cachexia

Published online by Cambridge University Press:  08 March 2007

Chen Bing
Chen Bing*
Affiliation:
Neuroendocrine & Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
*
[email protected]
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Abstract

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Type
Invited commentary
Information
British Journal of Nutrition , Volume 93 , Issue 6 , June 2005 , pp. 761 - 763
Copyright
Copyright © The Nutrition Society 2005

References

Anker, SD, Volterrani, M, Pflaum, CD, et al. (2001) Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone. J Am Coll Cardiol 38, 443–452.CrossRefGoogle ScholarPubMed
Argiles, JM, Busquets, S & Lopez-Soriano, FJ (2003) Cytokines in the pathogenesis of cancer cachexia. Curr Opin Clin Nutr Metab Care 6, 401–406.CrossRefGoogle ScholarPubMed
Bereket, A, Lang, CH, Blethen, SL, Gelato, MC, Fan, J, Frost, RA & Wilson, TA (1995) Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 80, 1312–1317.Google ScholarPubMed
Bing, C, Taylor, S, Tisdale, MJ & Williams, G (2001) Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J Neurochem 79, 1004–1012.CrossRefGoogle ScholarPubMed
Boulware, SD, Tamborlane, WV, Matthews, LS & Sherwin, RS (1992) Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism. Am J Physiol 262, E130–E133.Google ScholarPubMed
Cicoira, M, Kalra, PR & Anker, SD (2003) Growth hormone resistance in chronic heart failure and its therapeutic implications. J Card Fail 9, 219–226.CrossRefGoogle ScholarPubMed
Cioffi, WG, Gore, DC, Rue, LW 3rd, Carrougher, G, Guler, HP, McManus, WF & Pruitt, BA Jr (1994) Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. Ann Surg 220, 310–316 discussion 316–319.CrossRefGoogle ScholarPubMed
Clemmons, DR, Klibanski, A, Underwood, LE, McArthur, JWRidgway, EC, Beitins, IZ, Van Wyk, JJ (1981) Reduction of plasma immunoreactive somatomedin C during fasting in humans. J Clin Endocrinol Metab 53, 1247–1250.CrossRefGoogle ScholarPubMed
Cohen, P, Clemmons, DR & Rosenfeld, RG (2000) Does the GH–IGF axis play a role in cancer pathogenesis? Growth Horm IGF Res 10, 297–305.CrossRefGoogle ScholarPubMed
Crown, AL, Cottle, K, Lightman, SL, Falk, S, Mohamed-Ali, V, Armstrong, L, Millar, AB & Holly, JM (2002) What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated? Clin Endocrinol (Oxf) 56, 723–733.CrossRefGoogle Scholar
Cwyfan, Hughes SC, Cotterill, AM, Molloy, AR, Cassell, TB, Braude, N, Hinds, CJ, Wass, JA & Holly, JM (1992) The induction of specific proteases for insulin-like growth factor-binding proteins following major heart surgery. J Endocrinol 135, 135–145.CrossRefGoogle Scholar
Dean, HJ, Kellett, JG, Bala, RM, Guyda, HJ, Bhaumick, B, Posner, BI & Friesen, HG (1982) The effect of growth hormone treatment on somatomedin levels in growth hormone-deficient children. J Clin Endocrinol Metab 55, 1167–1173.CrossRefGoogle ScholarPubMed
Dewys, WD, Begg, C, Lavin, PT, et al. (1980) Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69, 491–497.CrossRefGoogle ScholarPubMed
Ding, H, Kopple, JD, Cohen, A & Hirschberg, R (1993) Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91, 2281–2287.CrossRefGoogle ScholarPubMed
Donaghy, A, Ross, R, Wicks, C, Hughes, SC, Holly, J, Gimson, A & Williams, R (1997) Growth hormone therapy in patients with cirrhosis: a pilot study of efficacy and safety. Gastroenterology 113, 1617–1622.CrossRefGoogle ScholarPubMed
Durai, R, Yang, W, Gupta, S, Seifalian, AM & Winslet, MC (2005) The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge. Int J Colorectal Dis 20, 203–220.CrossRefGoogle ScholarPubMed
Fearon, KC & Moses, AG (2002) Cancer cachexia. Int J Cardiol 85, 73–81.CrossRefGoogle ScholarPubMed
Fryburg, DA, Jahn, LA, Hill, SA, Oliveras, DM & Barrett, EJ (1995) Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 96, 1722–1729.CrossRefGoogle ScholarPubMed
Huang, Q, Nai, Y-J, Jiang, Z-W & Li, J-S (2005) Change of the growth hormone–insulin-like growth factor-I axis in patients with gastrointestinal cancer: related to tumour type and nutritional status. Br J Nutr 93, 853–858.CrossRefGoogle ScholarPubMed
Hussain, MA, Schmitz, O, Mengel, A, Glatz, Y, Christiansen, JS, Zapf, J & Froesch, ER (1994) Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest 94, 1126–1133.CrossRefGoogle ScholarPubMed
Iida, K, del Rincon, JP, Kim, DS, Itoh, E, Coschigano, KT, Kopchick, JJ & Thorner, MO (2004) Regulation of full-length and truncated growth hormone (GH) receptor by GH in tissues of lit/lit or bovine GH transgenic mice. Am J Physiol Endocrinol Metab 287, E566–E573.CrossRefGoogle ScholarPubMed
Jenkins, RC & Ross, RJ (1998) Acquired growth hormone resistance in adults. Baillieres Clin Endocrinol Metab 12, 315–329.CrossRefGoogle ScholarPubMed
Jones, JI & Clemmons, DR (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16, 3–34.Google ScholarPubMed
Kaaks, R & Lukanova, A (2001) Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 60, 91–106.CrossRefGoogle ScholarPubMed
Mazzoccoli, G, Giuliani, A, Bianco, G, De Cata, A, Balzanelli, M, Carella, AM, La Viola, M & Tarquini, R (1999) Decreased serum levels of insulin-like growth factor (IGF)-I in patients with lung cancer: temporal relationship with growth hormone (GH) levels. Anticancer Res 19, 1397–1399.Google ScholarPubMed
Oster, MH, Fielder, PJ, Levin, N & Cronin, MJ (1995) Adaptation of the growth hormone and insulin-like growth factor-I axis to chronic and severe calorie or protein malnutrition. J Clin Invest 95, 2258–2265.CrossRefGoogle ScholarPubMed
O'Sullivan, U, Gluckman, PD, Breier, BH, Woodall, S, Siddiqui, RA & McCutcheon, SN (1989) Insulin-like growth factor-1 (IGF-1) in mice reduces weight loss during starvation. Endocrinology 125, 2793–2794.CrossRefGoogle ScholarPubMed
Rinderknecht, E & Humbel, RE (1978) Primary structure of human insulin-like growth factor II. FEBS Lett 89, 283–286.CrossRefGoogle ScholarPubMed
Schaur, RJ, Fellier, H, Gleispach, H, Fink, E & Kronberger, L (1979) Tumor host relations. I. Increased plasma cortisol in tumor-bearing humans compared with patients with benign surgical diseases. J Cancer Res Clin Oncol 93, 281–285.CrossRefGoogle ScholarPubMed
Skjaerbaek, C, Frystyk, J, Orskov, H, Kissmeyer-Nielsen, P, Jensen, MB, Laurberg, S, Moller, N & Flyvbjerg, A (1998) Differential changes in free and total insulin-like growth factor I after major, elective abdominal surgery: the possible role of insulin-like growth factor-binding protein-3 proteolysis. J Clin Endocrinol Metab 83, 2445–2449.CrossRefGoogle ScholarPubMed
Tisdale, MJ (2002) Cachexia in cancer patients. Nat Rev Cancer 2, 862–871.CrossRefGoogle ScholarPubMed
Todorov, P, Cariuk, PMcDevitt, TColes, B, Fearon, K & Tisdale, M (1996) Characterization of a cancer cachectic factor. Nature 379, 739–742.CrossRefGoogle ScholarPubMed
Tomas, FM, Knowles, SE, Owens, PC, Read, LC, Chandler, CS, Gargosky, SE & Ballard, FJ (1991) Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J 276, 547–554.CrossRefGoogle ScholarPubMed