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The influence of pancreatic juice on 64Cu absorption in the rat

Published online by Cambridge University Press:  09 March 2007

M. H. Jamison ,
H. Sharma ,
J. M. Braganza  and
R. M. Case∥
M. H. Jamison
Affiliation:
University Department of Gastroenterology, Manchester Royal Infirmary, ManchesterM13 9WL
H. Sharma
Affiliation:
Department of Medical Biophysics Stopford Building, University of Manchester, ManchesterM13 9PT
J. M. Braganza
Affiliation:
University Department of Gastroenterology, Manchester Royal Infirmary, ManchesterM13 9WL
R. M. Case∥
Affiliation:
Departments of Physiology, Stopford Building, University of Manchester, ManchesterM13 9PT
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Abstract

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1. The absorption of 64Cu from closed duodeno-jejunal loops in anaesthetized rats was significantly less in the presence of pancreatic juice compared with that in the presence of saline (9 g sodium chloride/1). The inhibition of 64Cu absorption caused by pancreatic juice was similar to that achieved with bile.

2. Studies using solutions of electrolytes and of pancreatic extracts showed that the inhibitory effect of pancreatic secretions was due to its protein-enzyme content and not to its bicarbonate content.

Pancreatic secretion and bile influence Cu absorption and thereby affect Cu homeostasis.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 50 , Issue 1 , July 1983 , pp. 113 - 119
Copyright
Copyright © The Nutrition Society 1983

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