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Influence of low dietary lipid content on anorexia and [14C]glucose uptake in the intestine of zinc-deficient mice

Published online by Cambridge University Press:  09 March 2007

S. K. Taneja  and
P. Arya
S. K. Taneja
Affiliation:
Department of Zoology, Panjab University, Chandigarh 160014, India
P. Arya
Affiliation:
Department of Zoology, Panjab University, Chandigarh 160014, India
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Abstract

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Zinc deficiency was induced in adult male mice by feeding them for 8 weeks on a purified semi-synthetic Zn-deficient diet (ZD) containing 90 g lipid/kg (60 g maize oil plus 30 g cod-liver oil). One group was then fed on a low-lipid Zn-deficient diet (ZDLR) containing 30 g cod-liver oil/kg as the sole lipid source for a further 8 weeks. At the end of the experiment the stomach clearance rate, daily food intake, body-weight gain and [14C]glucose uptake in the intestine were significantly higher in group ZDLR than in mice that continued eating the Zn-deficient lipid-adequate diet ZD, and were comparable to results for a group given a Zn-supplemented diet. These results suggest that the pathogenesis of anorexia, nutrient malabsorption and growth retardation are secondary to lipid malabsorption resulting from Zn deficiency

Keywords

Dietary lipidAnorexiaGlucose uptakeZinc deficiencyMice
Type
Metabolic Effects of Altered Zinc Status
Information
British Journal of Nutrition , Volume 68 , Issue 2 , September 1992 , pp. 505 - 514
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Alvardo, F. & Mahmood, A. (1974). Co-transport of organic solutes in small intestine: A general model amino acid transport. Biochemistry 13, 2882–2890.Google Scholar
Ashley, D. V. M. & Anderson, G. H. (1975). Correlation between the plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. Journal of Nutrition 105, 1412–1421.Google Scholar
Baker, J. R. (1956). Improvements in the Sudan black B technique. Quarterly Journal of Microscopical Science 97, 621.Google Scholar
Butler, F. E. (1961). Determination of tritium in water and urine. Liquid scintillation counter and rate of drift determination. Annals of Chemistry 33, 409.CrossRefGoogle Scholar
Cain, A. J. (1947). Use of Nile blue in the examination of lipids. Quarterly Journal of Microscopical Science 88, 383.Google Scholar
Chesters, J. K. & Quarterman, J. (1970). Effects of Zn deficiency on food intake and feeding pattern of rats. British Journal of Nutrition 24, 1061–1069.CrossRefGoogle Scholar
Crane, R. K. & Mandelstain, P. (1960). The active transport of sugar by various preparation of hamster intestine. Biochimica et Biophysica Acta 45, 460–476.CrossRefGoogle ScholarPubMed
Essatara, M. B., McClain, C. J., Levin, E. S. & Morley, J. E. (1984). Zn-deficiency and anorexia in rats: The effect of central administration of norepinephrine, muscimol and bromergocryptine. Physiology and Behavior 32, 479–482.Google Scholar
Halas, E. S., Wallwork, J. C. & Sandstead, H. H. (1982). Mild zinc deficiency and under nutrition during prenatal and postnatal periods in rats: Effects on weight, food consumption and brain catecholamine concentrations. Journal of Nutrition 112, 542–551.Google Scholar
Henkin, R. I., Graziadei, P. P. G. & Bradley, D. E. (1969). The molecular basis of taste and its disorders. Annals of Internal Medicine 71, 791–919.Google Scholar
Ipsen, J. & Feigl, P. (1970). Bancrofts Introduction to Biostatistics, 2nd ed. New York: Harper and Row.Google Scholar
Isselbacher, K. J. & Budz, D. (1963). Synthesis of lipoprotein by rat intestinal mucosa. Nature 200, 363–365.Google Scholar
Konturek, S. & Grossman, M. I. (1965). Effect of perfusion of intestinal loops with acid, fat or dextrose on gastric secretion. Gastroenterology 49, 481–489.Google Scholar
Koo, S. I. & Turk, D. E. (1977). Effect of zinc deficiency on intestinal transport of triglyceride in the rat. Journal of Nutrition 107, 909–919.CrossRefGoogle ScholarPubMed
Long, J. F. & Brooks, F. P. (1965). Relation between inhibition of gastric secretion and absorption of fatty acids. American Journal of Physiology 209, 447–451.Google Scholar
McClain, C. J., Kasarkis, E. J. & Allen, J. J. (1985). Functional consequences of Zn-deficiency. Progress in Food and Nutrition Science 9, 185–226.Google Scholar
Moran, J. C. & Lyerly, A. (1985). The effects of severe Zn-deficiency on intestinal amino acid losses in the rat. Life Science 36, 2515–2521.Google Scholar
Prasad, A. S. (1984). Discovery and importance of zinc in human nutrition. Federation Proceedings 43, 2829–2834.Google Scholar
Robinson, J. W. L. & Alvardo, F. (1971). Interaction between sugar and amino acid transport system at the small intestinal brush border. A comparative study. Pflugers Archiv 326, 48–75.Google Scholar
Southon, S., Gee, J. M. & Johnson, I. T. (1986). Hexose absorption from jejunal loops in situ in zinc-deficient and Zn-supplemented rats. British Journal of Nutrition 55, 193–200.Google Scholar
Taneja, S. K. & Kaur, B. (1988). Lipids in mucosal epithelium of the intestine of mice fed on Zn-deficient diet. Current Science 57, 493–494.Google Scholar
Wallwork, J. C., Fosmire, G. J. & Sandstead, H. H. (1979). Cyclic feeding patterns and plasma amino acid concentrations in Zn-deficient rats. Federation Proceedings 38, 606.Google Scholar