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Influence of diet and β-agonist administration on plasma concentrations of growth hormone and insulin-like growth factor-1 in young steers

Published online by Cambridge University Press:  09 March 2007

J. M. Dawson ,
J. Craigon ,
P. J. Buttery  and
D. E. Beever
J. M. Dawson
Affiliation:
Department of Applied Biochemistry and Food Science, Faculty of Agricultural and Food Sciences, University of Nottingham Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD
J. Craigon
Affiliation:
Department of Applied Biochemistry and Food Science, Faculty of Agricultural and Food Sciences, University of Nottingham Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD
P. J. Buttery
Affiliation:
Department of Applied Biochemistry and Food Science, Faculty of Agricultural and Food Sciences, University of Nottingham Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD
D. E. Beever
Affiliation:
Department of Ruminant Nutrition and Metabolism. AFRC Institute for Grassland and Environmental Research, Hurley, Maidenhead, Berkshire SL6 5LR
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Abstract

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The effect of feeding grass silage or a forage–concentrate (dried grass–barley) diet ad lib. to young cattle on growth rate, plasma growth hormone (GH) and insulin-like growth factor-1 (IGF-1) concentrations was examined. The effect of including the β-adrenergic agonist cimaterol in the forage–concentrate diet was also investigated. Significantly higher growth rates were observed in animals fed on the forage–concentrate diet than in those fed on the silage diet (P < 0·001), and these were further enhanced by dietary inclusion of cimaterol (P < 0·05). Plasma GH levels were higher in the silage-fed animals (P < 0·001) but IGF-1 levels were significantly lower (P < 0·001) than in the forage–concentrate-fed animals. Cimaterol had no effect on mean plasma GH and IGF-1 concentrations. Nevertheless, plasma IGF-1 levels correlated positively with growth rate across all three treatments (r 0·84, P < 0·001, n 17). Spectral analysis of the GH data obtained for each animal was used to determine whether regular periodicities could be detected in the 24 h profile and whether they differed between the three treatment groups. Regular periodicities of four-five cycles/d were detected in the averaged GH profiles of the silage-fed and the control forage–concentrate-fed animals. In contrast, in animals given cimaterol regular GH cycles were not detectable at any of the frequencies tested. This suggests that cimaterol disrupts the rhythm of GH secretion without altering the overall mean concentrations. The data also suggest that due to an inadequate nutrient supply, the GH–IGF-1 regulatory mechanism was uncoupled in the cattle fed on silage, which may have contributed to the poor growth response of these animals.

Keywords

Spectral analysisGrowth hormonelnsulin-like growth factor-1ForageBovidae
Type
Diet and Hormonal Influences on Growth
Information
British Journal of Nutrition , Volume 70 , Issue 1 , July 1993 , pp. 93 - 102
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Breier, B. H., Bass, J. J., Butler, J. H. & Gluckman, P. D. (1986). The somatotrophic axis in young steers: influence of nutritional status on pulsatile release of growth hormone and circulating concentrations of insulin- like growth factor-1. Journal of Endocrinology 111, 209–215.Google Scholar
Breier, B. H. & Gluckman, P. D. (1991). The regulation of post-natal growth -nutritional influences on endocrine pathways and function of somatotrophic axis. Livestock Production Science 27, 77–94.CrossRefGoogle Scholar
Breier, B. H., Gluckman, P. D. & Bass, J. J. (1988 a). Influence of nutritional status and oestradiol-17&beta; on plasma growth hormone, insulin-like growth factors-1 and -11 and the response to exogenous growth hormone in young steers. Journal of Endocrinology 118, 243–250.CrossRefGoogle Scholar
Breier, B. H., Gluckman, P. D. & Bass, J. J. (1988 b). The somatotrophic axis in young steers: influence of nutritional status and oestradiol- 17&beta; on hepatic high- and low-affinity somatotrophic binding sites. Journal of Endocrinology 116, 169–177.CrossRefGoogle ScholarPubMed
Buttery, P. J. & Dawson, J. M. (1987). The mode of action of beta-agonists as manipulators of carcass composition. In Beta-Agonisrs and their Effects on Animal Growth and Carcass Quality, pp. 2943 [Hanrahan, J. P., editor]. London: Elsevier Applied Science.Google Scholar
Clemmons, D. R., Klibanski, A., Underwood, L. E., McArthur, J. W., Ridgway, E. C., Beitius, J. Z. & Van Wyk, J. J. (1981). Reduction of plasma immunoreactive somatostatin C during fasting in humans. Journal of Clinicu1 Endocrinology and Metabolism 53, 1247–1250.CrossRefGoogle Scholar
Dewar, W. A. & McDonald, P. (1961). Determination of dry matter in silage by distillation with toluene. Jourriul of the Science of Food and Agriculture 12, 790–795.CrossRefGoogle Scholar
Digby, P., Galway, N. & Lane, P. (1989). Genstat s, A Second Course. Oxford: Oxford Science Publications.Google Scholar
Diggle, P. J. (1990). Time Series A Biostaristical Introducrion. Oxford: Oxford Science Publications.CrossRefGoogle Scholar
Driver, P. M., Brown, W. B., Scanes, C. G. & Forbes, J. M. (1976). Serum growth hormone levels in growing lambs at two daylengths and two levels of feeding. Journal of Endocrinology 69, 44P–45P.Google ScholarPubMed
Eigenmann, J. E., de Bruijne, J. J. & Froesch, E. R. (1985). Insulin-like growth factor-l and growth hormone in canine starvation. Acta Endocrinologica 108, 161–166.Google Scholar
Elsasser, T. H., Rumsey, T. S. & Hammond, A. C. (1989). Influence of diet on basal and growth hormone-stimulated plasma concentrations of IGF-I in beef cattle. Journal of Animal Science 67, 128–141.CrossRefGoogle ScholarPubMed
England, P. & Gill, M. (1983). The effect of wilting and short-chopping of grass on the subsequent voluntary intake of silage, and liveweight gain of calves. Animal Production 36, 73–77.Google Scholar
Gill, M., Beever, D. E., Buttery, P. J., England, P., Gibb, M. J. & Baker, R. D. (1987). The effect of oestradiol- 17&beta; implantation on the response in voluntary intake, liveweight gain and body composition, to fishmeal supplementation of silage offered to growing calves. Journul of Agricultural Scietice, Cambridge 108, 9–16.CrossRefGoogle Scholar
Houseknecht, K. L., Boggs, D. L., Campion, D. R., Sartin, J. L., Kiser, T. E., Rampacek, G. B. & Amos, H. E. (1988). Effect of dietary source and level on serum growth hormone, insulin-like growth factor-1, growth and body composition in beef heifers. Journal of Animal Science 66, 2916–2923.CrossRefGoogle ScholarPubMed
Howles, C. M., Craigon, J. & Haynes, N. B. (1982). Long term rhythms of testicular volume and plasma prolactin concentrations in rams reared for 3 years in constant photoperiod. Journal of Reproduction and Fertility 65, 439–446.CrossRefGoogle ScholarPubMed
Jenkins, C. M. & Watts, D. G. (1968). The spectrum. In Spectral Analysis rind its Applicutions, pp. 209–257 [Jenkins, G.M. and Parzen, E. editors]. San Francisco: Holden-Day.Google Scholar
McLeod, B. J. & Craigon, J. (1985). Time series analysis of plasma LH and FSH concentrations as a method of assessing episodic secretion. Journal of Reproduction and Fertility 74, 575–587.CrossRefGoogle ScholarPubMed
Maltin, C. A., Delday, M. I., Hay, S. M., Innes, G. M. & Williams, P. E. V. (1990). Effects of bovine pituitary growth hormone alone or in combination with the &beta;-agonist clenbuterol on muscle growth and composition in veal calves. British Journal of Nutrition 63, 535–545.Google Scholar
Marsh, R. (1979). The effects of wilting on fermentation in the silo and on the nutritive value of silage. Grass and Forage Science 34, 1–10.Google Scholar
Merimee, T. J. & Finberg, S. E. (1974). Growth hormone secretion in starvation: a reassessment. Journal of Clinirnl Endocrinology and Metabolism 39, 385–386.Google Scholar
Moseley, W. M., Krabill, L. F. & Olsen, R. F. (1982). Effect of bovine growth hormone administered in various patterns on nitrogen metabolism in the Holstein steer. Journal of Animal Science 55, 1062–1072.CrossRefGoogle ScholarPubMed
Mounier, F., Bluet-Pajot, M. T., Durand, D., Kordon, C., Rasolonjanahary, R. & Epelbaum, J. (1989). Involvement of central somatostatin in the alteration of GH secretion in starved rats. Hormone Research 31, 266–270.Google Scholar
Payne, R. W., Lane, P. W., Ainsley, A. E., Bicknell, K. E., Digby, P. G. N., Harding, S. A., Leech, P. K., Simpson, H. R., Todd, A. D., Verrier, P. J. & Whyte, R. P. (1988). Genstat S Reference Manual. Oxford: Oxford University Press.Google Scholar
Pell, J. M., Elcock, C., Harding, R. L., Morrell, D. J., Simmonds, A. D. & Wallis, M. (1990). Growth body composition, hormonal and metabolic status in lambs treated long-term with growth hormone. British Journal of Nutrition 63, 431–445.Google Scholar
Perkins, S. N., Evans, W. S., Thorner, M. O. & Cronin, M. J. (1983). Beta-adrenergic stimulation of growth hormone release from perifused rat anterior pituitary cells. Neuroendocrinology 37, 473–475.CrossRefGoogle ScholarPubMed
Rahe, C.H., Owens, R. E., Fleeger, J. L., Newton, H. J. & Harms, P. G. (1980). Pattern of plasma luteinizing hormone in the cyclic cow: dependence upon the period of the cycle. Endocrinology 107, 498–503.Google Scholar
Reeds, P. J. & Mersmann, H. J. (1991). Protein and energy requirements of animals treated with beta-adrenergic agonists: a discussion. Journal of Animal Science 69, 1532–1550.Google Scholar
Ricks, C. A., Dalrymple, R. H., Baker, P. K. & Ingle, D. L. (1984). Use of a β agonist to alter fat and muscle deposition in steers. Journal of Agricultural Science 59, 1247–1255.Google Scholar
Ronge, H., Blum, J., Clement, C., Jam, F., Leuenberger, H. & Binder, H. (1988). Somatomedin C in dairy cows related to energy and protein supply and to milk production. Animal Production 47, 165–183.Google Scholar
Trenkle, A. (1976). Estimates of the kinetic parameters of growth hormone metabolism in fed and fasted calves and sheep. Journal of Animal Science 43, 1035–1043.Google Scholar
Welsh, T. H. Jr, Smith, S. B., Sutton, M. R. & Wagner, K. A. (1987). Growth hormone releasing factor and clenbuterol regulation of bovine growth hormone secretion in vitro. Journal of Animal Science 65, Suppl. 1, 279.Google Scholar
Wheaton, J. E., Al-Raheem, S. N., Massri, Y. G. & Marcek, J. M. (1986). Twenty-four-hour growth hormone profiles in Angus steers. Journal of Animal Science 62, 1267–1272.Google Scholar