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The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers

Published online by Cambridge University Press:  09 March 2007

T. A. B. Sanders  and
Alison Hinds
T. A. B. Sanders
Affiliation:
Department of Nutrition and Dietetics, King's College London, Campden Hill Road, London W8 7AH
Alison Hinds
Affiliation:
Department of Nutrition and Dietetics, King's College London, Campden Hill Road, London W8 7AH
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Abstract

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Nine healthy male subjects consumed a daily fish oil supplement providing 2.1 g docosahexaenoic acid (22:6 n-3; DHA) and 0.8 g eicosapentaenoic acid (20:5 n-3; EPA) for 6 weeks. The proportion of EPA and DHA in plasma, erythrocytes, leucocytes and platelet phospholipids was increased by the supplement. Plasma concentration of triacylglycerol and very-low-density-lipoprotein-cholesterol were lowered and those of high-density-lipotrotein (HDL)- and HDL2-cholesterol and apoprotein B were increased. Platelet aggregation and thromboxane B2 production induced by collagen were partially inhibited. Both systolic and diastolic blood pressure fell during treatment and rose following withdrawal of the supplement. Statistically significant reductions in erythrocyte counts, packed cell volume and haemoglobin and increases in total leucocyte and monocyte counts occurred with the supplement. Plasma α-tocopherol concentrations fell below the normal range during the period of supplementation. It is suggested that future studies consider components other than EPA in fish oil. Further studies are needed to investigate the extent to which fish oil increases the requirement for antioxidant nutrients.

Keywords

Dietary fatCoronary risk factorsVitamin EPolyunsaturated fatty acidsFish oil
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 163 - 173
Copyright
Copyright © The Nutrition Society 1992

References

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