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Infants in Trinidad excrete more 5-L-oxoproline (L-pyroglutamic acid) in urine than infants in England: an environmental not ethnic difference

Published online by Cambridge University Press:  22 August 2007

C. Lenton ,
Z. Ali ,
C. Persaud  and
A.A. Jackson
C. Lenton
Affiliation:
Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
Z. Ali
Affiliation:
Mount Hope Women's Hospital, Trinidad and Tobago, West Indies
C. Persaud
Affiliation:
Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
A.A. Jackson*
Affiliation:
Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
*
*Corresponding author: Professor Alan A. Jackson, fax +44 1703 594 383, email [email protected]
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Abstract

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The demand for glycine to satisfy normal growth during early life is considerable and most has to be made endogenously. The extent to which adequate glycine is available can be assessed by measuring the urinary excretion of 5-L-oxoproline. The excretion of 5-L-oxoproline at 6 weeks of age for infants in Trinidad of African, Indian or mixed parentage (398 μmol/mmol creatinine) was significantly greater than for infants born in England of Caucasian parentage (194 μmol/mmol creatinine). There was no relationship between 5-L-oxoproline excretion and either sex or pattern of feeding. There were significant inverse relationships between 5-L-oxoproline/creatinine and birth weight, and head circumference either at birth or 6 weeks of age, suggesting that limited availability of glycine is associated with poorer growth before and after birth. For a group of infants born in England of Indian parentage, excretion of 5-L-oxoproline (155 μmol/mmol creatinine) was not different to infants of Caucasian parentage, but significantly less than infants born in Trinidad. The demonstration that 5-L-oxoproline/creatinine was similar in infants born in England, regardless of parentage, shows that the differences between England and Trinidad are related to environment and are unlikely to be accounted for by genetic differences or ethnicity.

Keywords

5-L-OxoprolineGlycineGrowth
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 1 , July 1998 , pp. 51 - 55
Copyright
Copyright © The Nutrition Society 1998

References

Barker, DJP, Gluckman, PD, Godfrey, KM, Harding, JE, Owens, JA & Robinson, JS (1993) Fetal nutrition and cardiovascular disease in later life. Lancet 341, 938–941.CrossRefGoogle Scholar
Barker, DJP (1994) Mothers, babies and disease in later life. London: BMJ Publishing Group.Google Scholar
Forrester, TE, Wilks, RJ, Bennett, FI, Simeon, D, Osmond, C, Allen, M, Chung, AP & Scott, P (1996) Fetal growth and cardiovascular risk factors in Jamaican schoolchildren. British Medical Journal 312, 56–60.CrossRefGoogle ScholarPubMed
Garn, SM, Ridella, SA, Petzold, AS & Falkner, F (1981) Maternal hematologic levels and pregnancy outcomes. Seminars in Perinatology 5, 155–162.Google ScholarPubMed
Godfrey, KM, Forrester, T, Barker, DJP, Jackson, AA, Landman, JP, Hall, JSE & Cox, V (1994) Maternal nutritional status in pregnancy and blood pressure in childhood. British Journal of Obstetrics and Gynaecology 101, 398–403.CrossRefGoogle ScholarPubMed
Godfrey, KM, Redman, CWG, Barker, DJP & Osmond, C (1991) Effect of maternal anaemia and iron deficiency on ratio of fetal weight to placental weight. British Journal of Obstetrics and Gynaecology 98, 886–891.CrossRefGoogle ScholarPubMed
Jackson, AA (1989) Optimizing amino acid and protein supply and utilization in the newborn. Proceedings of the Nutrition Society 48, 293–301.CrossRefGoogle ScholarPubMed
Jackson, AA (1991) The glycine story. European Journal of Clinical Nutrition 45, 59–65.Google ScholarPubMed
Jackson, AA (1995) Salvage of urea nitrogen and protein requirements. Proceedings of the Nutrition Society 54, 535–547.CrossRefGoogle ScholarPubMed
Jackson, AA, Badaloo, AV, Forrester, T, Hibbert, JM & Persaud, C (1987) Urinary excretion of 5-oxoproline (pyroglutamic acid-uria) as an index of glycine insufficiency in normal man. British Journal of Nutrition 58, 207–214.CrossRefGoogle Scholar
Jackson, AA, Persaud, C, Hall, M, Smith, S, Evans, N & Rutter, N (1997 a) Urinary excretion of 5-L-oxoproline (pyroglutamic acid) during early life in normal term and preterm infants. Archives of Disease in Childhood 76, F152–F157.CrossRefGoogle ScholarPubMed
Jackson, AA, Persaud, C, Meakins, TS & Bundy, R (1996) Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased in normal adults consuming vegetarian or low protein diets. Journal of Nutrition 126, 2813–2822.Google ScholarPubMed
Jackson, AA, Persaud, C, Werkmeister, G, McClelland, ISM, Badaloo, A & Forrester, T (1997 b) Comparison of urinary excretion of 5-L-oxoproline (L-pyroglutamate) during normal pregnancy in women in England and Jamaica. British Journal of Nutrition 77, 183–196.CrossRefGoogle ScholarPubMed
Jackson, AA, Shaw, JCL, Barber, A & Golden, MHN (1981) Nitrogen metabolism in preterm infants fed human donor breast milk: the possible essentiality of glycine. Pediatric Research 15, 1454–1461.CrossRefGoogle ScholarPubMed
Jackson, AA & Wootton, SA (1990) The energy requirements of growth and catch-up growth. In Activity, Energy Expenditure and Energy Requirements of Infants and Children, p. 185 [Schurch, B and Scrimshaw, NS, editors]. Lausanne, Switzerland: IDECG.Google Scholar
Lumey, LH (1992) Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944–45. Paediatric and Perinatal Epidemiology 6, 240–253.CrossRefGoogle Scholar
Miller, GJ, Beckles, GLA, Alexis, SD, Byam, NTA & Price, SGL (1982) Serum lipoproteins and susceptibility of men of Indian descent to coronary heart disease. Lancet ii, 200–203.CrossRefGoogle Scholar
Miller, GJ, Beckles, GLA, Maude, GH, Carson, DC, Alexis, SD, Price, SGL & Byam, NTA (1989) Ethnicity and other characteristics predictive of coronary heart disease in a developing community: principal results of the St James survey, Trinidad. International Journal of Epidemiology 18, 808–817.CrossRefGoogle Scholar
Miller, GJ, Kirkwood, BR, Beckles, GLA, Alexis, SD, Carson, DC & Byam, NTA (1988) Adult male all-cause, cardiovascular and cerebrovascular mortality in relation to ethnic group, systolic blood pressure and blood glucose concentration in Trinidad, West Indies. International Journal of Epidemiology 17, 62–69.CrossRefGoogle ScholarPubMed
Neuberger, A (1981) The metabolism of glycine and serine. Comprehensive Biochemistry 19A, 257–303.Google Scholar
Persaud, C, McDermott, J, de Benoist, B & Jackson, AA (1989) The excretion of 5-oxoproline in urine as an index of glycine status, during normal pregnancy. British Journal of Obstetrics and Gynaecology 96, 440–444.CrossRefGoogle ScholarPubMed
Persaud, C, Pate, E, Forrester, T & Jackson, AA (1997) Urinary 5-L-oxoproline (pyroglutamic acid) excretion in Jamaican infants is greater than in English infants. European Journal of Clinical Nutrition 51, 510–513.CrossRefGoogle Scholar
Wilks, R, McFarlane-Anderson, N, Bennett, F, Fraser, H, McGee, D, Cooper, R & Forrester, T (1996) Obesity in peoples of the African diaspora. In The Origins and Consequences of Obesity, p. 37 [Chadwick, DJ and Cardew, G, eds]. Chichester: Wiley.Google Scholar
Wootton, SA & Jackson, AA (1996) Influence of under-nutrition in early life on growth, body composition and metabolic competence. In Long Term Consequences of Early Environment Growth: Development and the Lifespan Developmental Perspective, p. 109 [Henry, CJK and Ulijaszek, SJ, editors]. Cambridge: Cambridge University Press.Google Scholar
World Health Organization (1996) Investing in Health Research and Development: Report of an ad hoc Committee on Health Research relating to Future Intervention Options. Geneva: WHO.Google Scholar