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Infant intake of fatty acids from human milk over the first year of lactation

Published online by Cambridge University Press:  09 March 2007

Leon R. Mitoulas ,
Lyle C. Gurrin ,
Dorota A. Doherty ,
Jillian L. Sherriff  and
Peter E. Hartmann
Leon R. Mitoulas*
Affiliation:
Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
Lyle C. Gurrin
Affiliation:
Women and Infants Research Foundation and The University of Western AustraliaDepartment of Obstetrics and Gynaecology, King Edward Memorial Hospital, Subiaco WA 6008, Australia
Dorota A. Doherty
Affiliation:
Women and Infants Research Foundation and The University of Western AustraliaDepartment of Obstetrics and Gynaecology, King Edward Memorial Hospital, Subiaco WA 6008, Australia
Jillian L. Sherriff
Affiliation:
Department of Nutrition, Dietetics and Food Science, School of Public Health, Curtin University of Technology, GPO Box U1987, Perth WA 6845, Australia
Peter E. Hartmann
Affiliation:
Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
*
*Corresponding author: Dr L. R. Mitoulas, fax +61 8 9380 1148, email [email protected]
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Abstract

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Despite the importance of human milk fatty acids for infant growth and development, there are few reports describing infant intakes of individual fatty acids. We have measured volume, fat content and fatty acid composition of milk from each breast at each feed over a 24h period to determine the mean daily amounts of each fatty acid delivered to the infant from breast milk at 1, 2, 4, 6, 9 and 12 months of lactation in five women. Daily (24h) milk production was 336·60 (sem 26·21) and 414·49 (sem 28·39) ml and milk fat content was 36·06 (sem 1·37) and 34·97 (sem 1·50) g/l for left and right breasts respectively over the course of the first year of lactation. Fatty acid composition varied over the course of the day (mean CV 14·3 (sd 7·7) %), but did not follow a circadian rhythm. The proportions (g/100g total fatty acids) of fatty acids differed significantly between mothers (P<0·05) and over the first year of lactation (P<0·05). However, amounts (g) of most fatty acids delivered to the infant over 24h did not differ during the first year of lactation and only the amounts of 18:3n-3, 22:5n-3 and 22:6n-3 delivered differed between mothers (P<0·05). Mean amounts of 18:2n-6, 18:3n-3, 20:4n-6 and 22:6n-3 delivered to the infant per 24h over the first year of lactation were 2·380 (sd 0·980), 0·194 (sd 0·074), 0·093 (sd 0·031) and 0·049 (sd 0·021) g respectively. These results suggest that variation in proportions of fatty acids may not translate to variation in the amount delivered and that milk production and fat content need to be considered.

Keywords

Fatty acidsInfant nutritionHuman milk lipidsSampling protocolsBreast-feeding
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 5 , November 2003 , pp. 979 - 986
Copyright
Copyright © The Nutrition Society 2003

References

Arthur, PG, Hartmann, PE & Smith, M (1987) Measurement of the milk intake of breast-fed infants. J Pediatr Gastroenterol Nutr 6, 758–763.Google ScholarPubMed
Butte, NF, Garza, C, Smith, EO & Nichols, BL (1984) Human milk intake and growth in exclusively breast-fed infants. J Pediatr 104, 187–195.CrossRefGoogle ScholarPubMed
Christie, WW (1973) Lipid analysis. Isolation, Separation, Identification and Structural Analysis of Lipids. Oxford: Pergamon Press.Google Scholar
Cox, DB, Kent, JC, Casey, TM, Owens, RA & Hartmann, PE (1999) Breast growth and the urinary excretion of lactose during human pregnancy and early lactation: endocrine relationships. Exp Physiol 84, 421–434.CrossRefGoogle ScholarPubMed
Cox, DB, Owens, RA & Hartmann, PE (1996) Blood and milk prolactin and the rate of milk synthesis in women. Exp Physiol 81, 1007–1020.CrossRefGoogle ScholarPubMed
Cunnane, SC, Francescutti, V, Brenna, JT & Crawford, MA (2000) Breastfed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids 35, 105–111.CrossRefGoogle Scholar
Daly, SEJ, Di Rosso, A, Owens, RA & Hartmann, PE (1993) Degree of breast emptying explains changes in the fat content, but not fatty acid composition, of human milk. Exp Physiol 78, 741–755.Google Scholar
Del Prado, M, Villalpando, S, Lance, A, Alfonso, E, Demmelmair, H & Koletzko, B (2000) Contribution of dietary and newly formed arachidonic acid to milk (secretion in women on low fat diets). In Short and Long Term Effects of Breast Feeding on Child Health, pp. 407–408 [Koletzko, B, Michaelson, KF, Hernell, O, editors]. New York: Kluwer Academic/Plenum Publishers.Google Scholar
Farquharson, J, Cockburn, F, Patrick, WA, Jamieson, EC & Logan, RW (1993) Effect of diet on infant subcutaneous tissue triglyceride fatty acids. Arch Dis Child 69, 589–593.CrossRefGoogle ScholarPubMed
Folch, J, Lees, M, Sloane, Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509.CrossRefGoogle ScholarPubMed
Gibson, RA & Kneebone, GM (1981) Fatty acid composition of human colostrum and mature breast milk. Am J Clin Nutr 34, 252–257.CrossRefGoogle ScholarPubMed
Gibson, RA & Makrides, M (2000) n -3 Polyunsaturated fatty acid requirements of term infants. Am J Clin Nutr 71, Suppl., 251S–255S.CrossRefGoogle ScholarPubMed
Gibson, RA, Neumann, MA & Makrides, M (1996) Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. Lipids 31, Suppl., S177–S181.CrossRefGoogle ScholarPubMed
Hachey, DL (1994) Benefits and risks of modifying maternal fat intake in pregnancy and lactation. Am J Clin Nutr 59, Suppl., 454S–463S.CrossRefGoogle ScholarPubMed
Hall, B (1979) Uniformity of human milk. Am J Clin Nutr 32, 304–312.CrossRefGoogle ScholarPubMed
Hartmann, PE, Mitoulas, LR & Sherriff, JL (2000) Synthesis and secretion of fat in human milk and its role in infant development. J Integr Study Diet Habits 10, 65–73.CrossRefGoogle Scholar
Hartmann, PE, Morgan, SEG & Arthur, PG (1986) Milk let-down and the concentration of fat in breast milk. In Human Lactation 2: Maternal and Environmental Factors, pp. 275–281 [Hamosh, M, Goldman, AS, editors]. NewYork: Plenum Press.CrossRefGoogle Scholar
Huisman, M, Van Beusekom, M, Lanting, CI, Nijeboer, HJ, Muskiet, FA & Boersma, ER (1996) Triglycerides, fatty acids, sterols, mono- and disaccharides and sugar alcohols in human milk and current types of infant formula milk. Eur J Clin Nutr 50, 255–260.Google ScholarPubMed
Hytten, FE (1954) Clinical and chemical studies in human lactation: I. Collection of milk samples. II. Variation in major constituents during feeding. III. Diurnal variation in major constituents in milk. Brit Med J 23, 175–182.CrossRefGoogle Scholar
Idota, T, Sakurai, M, Sugawara, Y et al. (1991) The latest survey for the composition of milk obtained from Japanese mothers. Part II. Changes of fatty acid composition, phospholipid and cholesterol contents during lactation. Jpn J Pediatr Gastroenterol Nutr 5, 159–173.Google Scholar
Innis, SM, Gilley, J & Werker, J (2001) Are human long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants? J Pediatr 139, 532–538.CrossRefGoogle ScholarPubMed
Innis, SM & Kuhnlein, HV (1988) Long chain n -3 fatty acids in breast milk of Inuit women consuming traditional foods. Early Hum Dev 18, 185–189.CrossRefGoogle ScholarPubMed
Isaacs, CE, Thormar, H & Pessolano, T (1986) Membrane-disruptive effect of human milk: inactivation of enveloped viruses. J Infect Dis 154, 966–971.CrossRefGoogle ScholarPubMed
Jensen, RG (1989) The Lipids of Human Milk. Boca Raton, FL: CRC Press.Google Scholar
Jensen, RG, Bitman, J, Carlson, SE, Couch, SC, Hamosh, M & Newberg, DS (1995) Milk Lipids. In Handbook of Milk Composition, pp. 495–576 [Jensen, RG, editor]. San Diego, CA: Academic Press.CrossRefGoogle Scholar
Kent, JC, Mitoulas, LR, Cox, DB, Owens, RA & Hartmann, PE (1999) Breast volume and milk production during extended lactation in women. Exp Physiol 84, 435–447.CrossRefGoogle ScholarPubMed
Kneebone, GM, Kneebone, R & Gibson, RA (1985) Fatty acid composition of breast milk from three racial groups from Penang, Malaysia. Am J Clin Nutr 41, 765–769.CrossRefGoogle ScholarPubMed
Luukkainen, P, Salo, MK & Nikkari, T (1994) Changes in the fatty acid composition of preterm and term human milk from 1 week to 6 months of lactation. J Pediatr Gastroenterol Nutr 18, 355–360.Google ScholarPubMed
Makrides, M, Simmer, K, Neumann, MA & Gibson, RA (1995) Changes in the polyunsaturated fatty acids of breast milk from mothers of full term infants over 30?wk of lactation. Am J Clin Nutr 61, 1231–1233.CrossRefGoogle Scholar
Marangoni, F, Agostoni, C, Lammardo, AM, Giovannini, M, Galli, C & Riva, E (2000) Polyunsaturated fatty acid concentrations in human hindmilk are stable throughout 12-months of lactation and provide a sustained intake to the infant during exclusive breastfeeding: an Italian study. Brit J Nutr 84, 103–109.CrossRefGoogle Scholar
Mitoulas, LR, Kent, JC, Cox, DB, Owens, RA, Sherriff, JL & Hartmann, PE (2002) Variation in fat, lactose and protein in human milk over 24?h and throughout the first year of lactation. Brit J Nutr 88, 29–37.CrossRefGoogle Scholar
Read, WWC, Lutz, PG & Tashjian, A (1965) Human Milk Lipids II. The influence of dietary carbohydrates and fat on the fatty acids of mature milk. A study in four ethnic groups. Am J Clin Nutr 17, 180–183.CrossRefGoogle ScholarPubMed
Stern, I & Shapiro, B (1953) A rapid and simple method for the determination of esterified fatty acids and for total fatty acids in blood. J Clin Pathol 6, 158.CrossRefGoogle ScholarPubMed