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The in vitro metabolism of 25-hydroxycholecalciferol by pig kidney: effect of low dietary levels of calcium and phosphorus

Published online by Cambridge University Press:  09 March 2007

Barbara A. Sommerville ,
J. Fox ,
A. D. Care  and
R. Swaminathan
Barbara A. Sommerville
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
J. Fox
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
A. D. Care
Affiliation:
Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
R. Swaminathan
Affiliation:
Department of Chemical Pathology, The General Infirmary, Leeds LS1 3EX
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Abstract

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1. Homogenates of pig kidney incubated in vitro convert 25-hydroxycholecalciferol to the dihydroxy-metabolites almost as efficiently as homogenates of chick kidney under similar conditions.

2. The cortex of the kidney carries out this conversion more efficiently than does the medulla.

3. Kidneys from pigs given low calcium or low phosphorus diets produce about 40 % more 1,25-dihydroxy cholecalciferol than those from pigs given diets containing normal levels of Ca and P.

Type
Short Papers
Information
British Journal of Nutrition , Volume 40 , Issue 1 , July 1978 , pp. 159 - 162
Copyright
Copyright © The Nutrition Society 1978

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