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The importance of the non-protein components of the diet in the plasma cholesterol response of rabbits to casein

Zinc and copper

Published online by Cambridge University Press:  09 March 2007

S. Samman  and
D. C. K. Roberts
S. Samman
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
D. C. K. Roberts
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
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Abstract

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1. To characterize further the effect of protein-mineral interaction on plasma cholesterol, four groups of rabbits were placed on cholesterol-free, semi-purified diets for 12 weeks. The diets were similar in proximate composition with either casein or soya-bean protein isolate as the protein source (250 g/kg).

2. The dietary zinc content of the casein diets was increased to 22 mg/kg to equal that of the soya-bean diets. The copper content was set at 2 and 6 mg/kg. There were no differences in weight gain; all animals grew at a similar rate.

3. When the dietary Zn content was equalized, the plasma and liver cholesterol responses were similar regardless of the source of protein.

4. Differences in liver Cu and Zn were observed. As dietary Cu increased, Cu decreased and Zn increased in the liver. Hepatic Zn was also higher in soya-bean-fed than in casein-fed animals.

5. No effects on plasma Cu and Zn were seen.

6. The addition of Zn to the casein diet resulted in a similar plasma cholesterol to that of animals fed on the soya-bean diet, suggesting that casein-induced hypercholesterolaemia is due to a marginal Zn intake.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 1 , January 1987 , pp. 27 - 33
Copyright
Copyright © The Nutrition Society 1987

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