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Impact of inulin and oligofructose on gastrointestinal peptides

Published online by Cambridge University Press:  08 March 2007

Nathalie M. Delzenne ,
Patrice D. Cani ,
Catherine Daubioul  and
Audrey M. Neyrinck
Nathalie M. Delzenne*
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD/FARM/PMNT 7369, Université Catholique de Louvain, Avenue E Mounier 73, B-1200, Brussels, Belgium
Patrice D. Cani
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD/FARM/PMNT 7369, Université Catholique de Louvain, Avenue E Mounier 73, B-1200, Brussels, Belgium
Catherine Daubioul
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD/FARM/PMNT 7369, Université Catholique de Louvain, Avenue E Mounier 73, B-1200, Brussels, Belgium
Audrey M. Neyrinck
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD/FARM/PMNT 7369, Université Catholique de Louvain, Avenue E Mounier 73, B-1200, Brussels, Belgium
*
*Corresponding author: Dr N. M. Delzenne, fax +32 2 7647359, email [email protected]
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Abstract

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In the present paper, we summarise the data supporting the following hypothesis: dietary inulin-type fructans extracted from chicory root may modulate the production of peptides, such as incretins, by endocrine cells present in the intestinal mucosa, this phenomenon being involved in the regulation of food intake and/or systemic effects. To test this hypothesis, male Wistar rats received for 3 weeks either a standard diet or the same diet supplemented with 10% inulin-type fructans with different degrees of polymerisation. All the effects were most pronounced with the diet containing oligofructose, and consisted of (i) a decrease in mean daily energy intake and in epididymal fat mass; (ii) a higher caecal pool of the anorexigenic glucagon-like peptide-1 (7–36) amide (GLP-1), and peptide YY (PYY), due to caecal tissue proliferation; (iii) an increase in GLP-1 and of its precursor – proglucagon mRNA – concentrations in the proximal colon; (iv) an increase in portal serum level of GLP-1 and PYY; (v) a decrease in serum orexigenic peptide ghrelin. Moreover, oligofructose supplementation improved glucose homeostasis (i.e. decreased glycaemia, increased pancreatic and serum insulin content) in diabetic rats previously treated with streptozotocin, a phenomenon that is partly linked to the reduction in food intake and that correlates with the increase in colic and portal GLP-1 content. Based on these results it appears justified to test, in human subjects, the hypothesis that dietary inulin-type fructans could play a role in the management of obesity and diabetes through their capacity to promote secretion of endogenous gastrointestinal peptides involved in appetite regulation.

Keywords

OligofructoseGlucagon-like peptide-1Peptide YYGhrelinRats
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue S1 , April 2005 , pp. S157 - S161
Copyright
Copyright © The Nutrition Society 2005

References

Brubaker, PL & Drucker, DJ (2004) Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 145, 2653–2659.CrossRefGoogle ScholarPubMed
Burcelin, R, Da Costa, A, Drucker, D & Thorens, B (2001) Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 50, 1720–1728.CrossRefGoogle ScholarPubMed
Cani, PD, Dewever, C & Delzenne, NM (2004a) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521–526.CrossRefGoogle ScholarPubMed
Cani, PD, Daubioul, C, Reusens, B, Remacle, C, Catillon, G & Delzenne, NM (2004b) Involvement of food restriction and endogenous GLP-1 (7–36) amide in glycemia-lowering effect of dietary oligofructose in streptozotocin diabetic rats. Regul Pept 122, 12–13.Google Scholar
Daubioul, C, De Wispelaere, L, Taper, H & Delzenne, N (2000) Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats. J Nutr 130, 1314–1319.CrossRefGoogle Scholar
Daubioul, C, Rousseau, N, Demeure, R, Gallez, B, Taper, H, Declercq, B & Delzenne, N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa / fa rats. J Nutr 132, 967–973.CrossRefGoogle Scholar
Delzenne, N (2003) Oligosaccharides: state of the art. Proc Nutr Soc 62, 177–182.CrossRefGoogle ScholarPubMed
Delzenne, N & Kok, N (2001) Effects of fructans-type prebiotics on lipid metabolism. Am J Clin Nutr 73, 456S–458S.CrossRefGoogle ScholarPubMed
Drozdowski, LA, Dixon, WT, McBurney, MI & Thomson, AB (2002) Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression. J Parenter Enteral Nutr 26, 145–150.CrossRefGoogle ScholarPubMed
Druce, MR, Small, CJ & Bloom, SR (2004) Gut peptides regulating satiety. Endocrinology 145, 2660–2665.CrossRefGoogle ScholarPubMed
Drucker, DJ (2002) Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122, 531–544.CrossRefGoogle ScholarPubMed
Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H & Kangawa, K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.CrossRefGoogle ScholarPubMed
Lippl, F, Kircher, F, Erdmann, J, Allescher, HD & Schusdziarra, V (2004) Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regul Pept 119, 93–98.CrossRefGoogle ScholarPubMed
Massimino, SP, McBurney, MI, Field, CJ, Thomson, AB, Keelan, M, Hayek, MG & Sunvold, GD (1998) Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr 128, 1786–1793.CrossRefGoogle ScholarPubMed
Nie, Y, Nakashima, M, Brubaker, PL, Li, QL, Perfetti, R, Jansen, E, Zambre, Y, Pipeleers, D & Friedman, TC (2000) Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest 105, 955–965.CrossRefGoogle ScholarPubMed
Perrin, IV, Marchesini, M, Rochat, FC, Schiffrin, EJ & Schilter, B (2003) Oligofructose does not affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model. Diabetes Nutr Metab 16, 94–101.Google Scholar
Piche, T, des Varannes, SB, Sacher-Huvelin, S, Holst, JJ, Cuber, JC & Galmiche, JP (2003) Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology 124, 894–902.CrossRefGoogle ScholarPubMed
Reimer, RA & McBurney, MI (1996) Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology 137, 3948–3956.CrossRefGoogle ScholarPubMed
Roberfroid, MB & Delzenne, NM (1998) Dietary fructans. Annu Rev Nutr 18, 117–143.CrossRefGoogle ScholarPubMed
Robertson, MD, Currie, JM, Morgan, LM, Jewell, DP & Frayn, KN (2003) Prior short-term consumption of resistant starch enhances post-prandial insulin sensitivity in healthy subjects. Diabetologia 46, 659–665.CrossRefGoogle ScholarPubMed
Schwartz, GJ (2000) The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16, 866–873.CrossRefGoogle ScholarPubMed
Stanley, S, Wynne, K & Bloom, S (2004) Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am J Physiol (Gastrointest Liver Physiol) 286, G693–G697.CrossRefGoogle ScholarPubMed
Tappenden, KA, Drozdowski, LA, Thomson, AB & McBurney, MI (1998) Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats. Am J Clin Nutr 68, 118–125.CrossRefGoogle ScholarPubMed
Tourrel, C, Bailbe, D, Meile, MJ, Kergoat, M & Portha, B (2001) Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in STZ-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 50, 1562–1570.CrossRefGoogle Scholar
Tschop, M, Smiley, DL & Heiman, ML (2000) Ghrelin induces adiposity in rodents. Nature 407, 908–913.CrossRefGoogle ScholarPubMed