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High rates of exogenous carbohydrate oxidation from a mixture of glucose and fructose ingested during prolonged cycling exercise

Published online by Cambridge University Press:  08 March 2007

Roy L. P. G. Jentjens  and
Asker E. Jeukendrup
Roy L. P. G. Jentjens
Affiliation:
Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston B15 2TT, UK
Asker E. Jeukendrup*
Affiliation:
Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston B15 2TT, UK
*
*Corresponding author: Dr Asker E. Jeukendrup, fax +44 (0)121 414 4121, email [email protected]
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Abstract

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A recent study from our laboratory has shown that a mixture of glucose and fructose ingested at a rate of 1·8 g/min leads to peak oxidation rates of approximately 1·3 g/min and results in approximately 55 % higher exogenous carbohydrate (CHO) oxidation rates compared with the ingestion of an isocaloric amount of glucose. The aim of the present study was to investigate whether a mixture of glucose and fructose when ingested at a high rate (2·4 g/min) would lead to even higher exogenous CHO oxidation rates (>1·3 g/min).Eight trained male cyclists (VO2max: 68±1 ml/kg per min) cycled on three different occasions for 150 min at 50 % of maximal power output (60±1 % VO2max) and consumed either water (WAT) or a CHO solution providing 1·2 g/min glucose (GLU) or 1.2 g/min glucose+1·2 g/min fructose (GLU+FRUC). Peak exogenous CHO oxidation rates were higher (P<0·01) in the GLU+FRUC trial compared with the GLU trial (1·75 (se 0·11) and 1·06 (se 0·05) g/min, respectively). Furthermore, exogenous CHO oxidation rates during the last 90 min of exercise were approximately 50 % higher (P<0·05) in GLU+FRUC compared with GLU (1·49 (se 0·08) and 0·99 (se 0·06) g/min, respectively). The results demonstrate that when a mixture of glucose and fructose is ingested at high rates (2·4 g/min) during 150 min of cycling exercise, exogenous CHO oxidation rates reach peak values of approximately 1·75 g/min.

Keywords

Substrate utilizationStable isotopesIntestinal carbohydrate transport
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 4 , April 2005 , pp. 485 - 492
Copyright
Copyright © The Nutrition Society 2005

References

Adopo, E, Peronnet, F, Massicotte, D, Brisson, GR & Hillaire-Marcel, C (1994) Respective oxidation of exogenous glucose and fructose given in the same drink during exercise. J Appl Physiol 76, 1014–1019.CrossRefGoogle ScholarPubMed
Bjorkman, O, Crump, M & Phillips, RW (1984) Intestinal metabolism of orally administered glucose and fructose in Yucatan miniature swine. J Nutr 114, 1413–1420.CrossRefGoogle ScholarPubMed
Bjorkman, O, Eriksson, LS, Nyberg, B & Wahren, J (1990) Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients. Diabetes 39, 747–751.CrossRefGoogle ScholarPubMed
Borg, G (1982) Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling strength test. Int J Sports Med 3, 153–158.CrossRefGoogle Scholar
Bosch, AN, Dennis, SC & Noakes, TD (1994) Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise. J Appl Physiol 76, 2364–2372.CrossRefGoogle ScholarPubMed
Burant, CF, Takeda, J, Brot-Laroche, E, Bell, GL & Davidson, NO (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 267, 14523–14526.CrossRefGoogle ScholarPubMed
Coggan, AR & Coyle, EF (1987) Reversal of fatigue during prolonged exercise by carbohydrate infusion or ingestion. J Appl Physiol 63, 2388–2395.CrossRefGoogle ScholarPubMed
Corpe, CP, Burant, CF & Hoekstra, JH (1999) Intestinal fructose absorption: clinical and molecular aspects. J Pediatr Gastroenterol Nutr 28, 364–374.Google ScholarPubMed
Coyle, EF, Coggan, AR, Hemmert, MK & Ivy, JL (1986) Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 61, 165–172.CrossRefGoogle ScholarPubMed
Craig, H (1957) Isotopic standards for carbon and oxygen and correction factors. Geochim Cosmochim Acta 12, 133–149.CrossRefGoogle Scholar
Davidson, RE & Leese, HJ (1977) Sucrose absorption by the rat small intestine in vivo and in vitro. J Physiol 267, 237–248.CrossRefGoogle ScholarPubMed
Ferraris, RP & Diamond, J (1997) Regulation of intestinal sugar transport. Physiol Rev 77, 257–302.CrossRefGoogle ScholarPubMed
Fine, KD, Santa, Ana CA, Porter, JL & Fordtran, JS (1994) Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo. Gastroenterology 107, 389–395.CrossRefGoogle ScholarPubMed
Frayn, KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55, 628–634.CrossRefGoogle ScholarPubMed
Fujisawa, T, Mulligan, K, Wada, L, Schumacher, L, Riby, J & Kretchmer, N (1993) The effect of exercise on fructose absorption. Am J Clin Nutr 58, 75–79.CrossRefGoogle ScholarPubMed
Fujisawa, T, Riby, J & Kretchmer, N (1991) Intestinal absorption of fructose in the rat. Gastroenterology 101, 360–367.CrossRefGoogle ScholarPubMed
Gray, GM & Ingelfinger, FJ (1966) Intestinal absorption of sucrose in man: interrelation of hydrolysis and monosaccharide product absorption. J Clin Invest 45, 388–398.CrossRefGoogle ScholarPubMed
Hanson, PJ & Parsons, DS (1976) The utilization of glucose and production of lactate by in vitro preparations of rat small intestine: effects of vascular perfusion. J Physiol 255, 775–795.CrossRefGoogle ScholarPubMed
Hawley, JA, Dennis, SC & Noakes, TD (1992) Oxidation of carbohydrate ingested during prolonged endurance exercise. Sports Med 14, 27–42.CrossRefGoogle ScholarPubMed
Hoekstra, JH & van den Aker, JH (1996) Facilitating effect of amino acids on fructose and sorbitol absorption in children. J Pediatr Gastroenterol Nutr 23, 118–124.Google ScholarPubMed
Holdsworth, CD & Dawson, AM (1964) The absorption of monosaccharides in man. Clin Sci 27, 371–379.Google ScholarPubMed
Holloway, PA & Parsons, DS (1984) Absorption and metabolism of fructose by rat jejunum. Biochem J 222, 57–64.CrossRefGoogle ScholarPubMed
Jandrain, BJ, Pallikaris, N, Normand, S, Pirnay, F, Lacroix, M, Mosora, F, Pachiaudi, C, Gautier, JF, Scheen, AJ, Riou, JP, Lefèbvre, PJ (1993) Fructose utilization during exercise in men: rapid conversion of ingested fructose to circulating glucose. J Appl Physiol 74, 2146–2154.CrossRefGoogle ScholarPubMed
Jentjens, RL, Achten, J & Jeukendrup, AE (2004a) High oxidation rates from combined carbohydrates ingested during exercise. Med Sci Sports Exerc 36, 1551–1558.CrossRefGoogle ScholarPubMed
Jentjens, RL, Moseley, L, Waring, RH, Harding, LK & Jeukendrup, AE (2004b) Oxidation of combined ingestion of glucose and fructose during exercise. J Appl Physiol 96, 1277–1284.CrossRefGoogle ScholarPubMed
Jentjens, RL, Venables, MC & Jeukendrup, AE (2004c) Oxidation of exogenous glucose, sucrose, and maltose during prolonged cycling exercise. J Appl Physiol 96, 1285–1291.CrossRefGoogle ScholarPubMed
Jentjens, RLPG, Shaw, C, Birtles, T, Waring, RH, Harding, LE, Jeukendrup, AEOxidation of combined ingestion of glucose and sucrose during exercise Metabolism in pressGoogle Scholar
Jeukendrup, AE & Jentjens, R (2000) Oxidation of carbohydrate feedings during prolonged exercise: current thoughts, guidelines and directions for future research. Sports Med 29, 407–424.CrossRefGoogle ScholarPubMed
Jeukendrup, AE, Vet-Joop, K, Sturk, A, Stegen, JH, Senden, J, Saris, WHM & Wagenmakers, AJM (2000) Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci 98, 47–55.CrossRefGoogle ScholarPubMed
Jeukendrup, AE, Wagenmakers, AJM, Stegen, JHCH, Gijsen, AP, Brouns, F & Saris, WHM (1999) Carbohydrate ingestion can completely suppress endogenous glucose production during exercise. Am J Physiol 276, E672–E683.Google ScholarPubMed
Koivisto, VA, Karonen, SL & Nikkila, EA (1981) Carbohydrate ingestion before exercise: comparison of glucose, fructose, and sweet placebo. J Appl Physiol 51, 783–787.CrossRefGoogle ScholarPubMed
Kuipers, H, Verstappen, FTJ, Keizer, HA, Geurten, P, van Kranenburg, G (1985) Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med 6, 197–201.CrossRefGoogle ScholarPubMed
Macdonald, I, Keyser, A & Pacy, D (1978) Some effects, in man, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood. Am J Clin Nutr 31, 1305–1311.CrossRefGoogle ScholarPubMed
Massicotte, D, Peronnet, F, Allah, C, Hillaire-Marcel, C, Ledoux, M & Brisson, G (1986) Metabolic response to [ 13 C]glucose and [ 13 C]fructose ingestion during exercise. J Appl Physiol 61, 1180–1184.CrossRefGoogle ScholarPubMed
Massicotte, D, Peronnet, F, Brisson, G, Bakkouch, K, Hillaire-Marcel, C (1989) Oxidation of a glucose polymer during exercise: comparison with glucose and fructose. J Appl Physiol 66, 179–183.CrossRefGoogle ScholarPubMed
Massicotte, D, Peronnet, F, Brisson, G, Boivin, L, Hillaire-Marcel, C (1990) Oxidation of exogenous carbohydrate during prolonged exercise in fed and fasted conditions. Int J Sports Med 11, 253–258.CrossRefGoogle ScholarPubMed
Mosora, F, Lefebvre, P, Pirnay, F, Lacroix, M, Luyckx, A & Duchesne, J (1976) Quantitative evaluation of the oxidation of an exogenous glucose load using naturally labeled 13 C-glucose. Metabolism 25, 1575–1582.CrossRefGoogle Scholar
Murray, R, Paul, GL, Seifert, JG, Eddy, DE & Halaby, GA (1989) The effects of glucose, fructose, and sucrose ingestion during exercise. Med Sci Sports Exerc 21, 275–282.CrossRefGoogle ScholarPubMed
Nicholls, TJ, Leese, HJ & Bronk, JR (1983) Transport and metabolism of glucose by rat small intestine. Biochem J 212, 183–187.CrossRefGoogle ScholarPubMed
Pallikarakis, N, Sphiris, N & Lefebvre, P (1991) Influence of the bicarbonate pool and on the occurrence of 13 CO 2 in exhaled air. Eur J Appl Physiol 63, 179–183.CrossRefGoogle Scholar
Porteous, JW (1978) Glucose as a fuel for small intestine. Biochem Soc Trans 6, 534–539.CrossRefGoogle ScholarPubMed
Ravich, WJ, Bayless, TM & Thomas, M (1983) Fructose: incomplete intestinal absorption in humans. Gastroenterology 84, 26–29.CrossRefGoogle ScholarPubMed
Riby, JE, Fujisawa, T & Kretchmer, N (1993) Fructose absorption. Am J Clin Nutr 58, 748S–753SCrossRefGoogle ScholarPubMed
Robert, JJ, Koziet, J, Chauvet, D, Darmaun, D, Desjeux, JF & Young, VR (1987) Use of 13 C-labeled glucose for estimating glucose oxidation: some design considerations. J Appl Physiol 63, 1725–1732.CrossRefGoogle Scholar
Rumessen, JJ, Gudmand-Hoyer, E (1986) Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut 27, 1161–1168.CrossRefGoogle ScholarPubMed
Sandle, GI, Lobley, RW, Warwick, R & Holmes, R (1983) Monosaccharide absorption and water secretion during disaccharide perfusion of the human jejunum. Digestion 26, 53–60.CrossRefGoogle ScholarPubMed
Shi, X, Schedl, HP, Summers, RM, Lambert, GP, Chang, RT, Xia, T & Gisolfi, CV (1997) Fructose transport mechanisms in humans. Gastroenterology 113, 1171–1179.CrossRefGoogle ScholarPubMed
Shi, X, Summers, RW, Schedl, HP, Flanagan, SW, Chang, R & Gisolfi, CV (1995) Effects of carbohydrate type and concentration and solution osmolality on water absorption. Med Sci Sports 27, 1607–1615.Google ScholarPubMed
Wagenmakers, AJM, Brouns, F, Saris, WHM & Halliday, D (1993) Oxidation rates of orally ingested carbohydrates during prolonged exercise in man. J Appl Physiol 75, 2774–2780.CrossRefGoogle Scholar