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High intakes of trans monounsaturated fatty acids taken for 2 weeks do not influence procoagulant and fibrinolytic risk markers for CHD in young healthy men

Published online by Cambridge University Press:  09 March 2007

Thomas A. B. Sanders ,
Francesca R. Oakley ,
David Crook ,
Jackie A. Cooper  and
George J. Miller
Thomas A. B. Sanders*
Affiliation:
Nutrition Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
Francesca R. Oakley
Affiliation:
Nutrition Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
David Crook
Affiliation:
Department of Cardiovascular Biochemistry, Charterhouse Square, London EC1M 6BQ, UK
Jackie A. Cooper
Affiliation:
Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute, St Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
George J. Miller
Affiliation:
Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute, St Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
*
*Corresponding author: Professor T. A. B. Sanders, fax +44 207 848 4171, email [email protected]
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Abstract

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Dietary trans fatty acids are associated with increased risk of CHD. We hypothesized that the changes in plasma lipids associated with a high intake of trans fatty acids would cause adverse effects on procoagulant and fibrinolytic activities. A randomized crossover controlled feeding study was conducted in twenty-nine men. A trans-rich diet supplying 10 % energy as trans- 18:1 was compared with diets in which the trans fatty acids were replaced either with carbohydrate or oleate; each diet was taken for 2 weeks in random order. Fasting fibrinogen and D-dimer concentrations and factor VII coagulant, plasminogen activator inhibitor type 1 and tissue plasminogen activator did not differ between diets. Postprandially, tissue plasminogen activator activity increased and plasminogen activator inhibitor type 1 activity decreased on all diets. Factor VIIc increased postprandially by 15 and 17 % on the trans and oleate diets respectively, compared with an 11 % increase on the carbohydrate diet; the mean difference between oleate and carbohydrate diets was 6 (95 % CI 0·2, 11·9) %. The LDL-cholesterol:HDL-cholesterol and apolipoprotein B: apolipoprotein A-I ratios increased by 13 (95 % CI 5·7, 21·8) and 10 (95 % CI 3·1, 17·2) % respectively on the trans diet compared with the oleate diet and by 6 (95 % CI 0·1,12·7) and 7 (95 % CI 0, 13·5) % respectively compared with the carbohydrate diet. Plasma HDL2-cholesterol concentration was 18 (95 % CI 0·7, 35·9) % lower on the trans diet compared with the oleate diet. The results confirm adverse effects of trans fatty acids on HDL-cholesterol concentrations, but suggest that trans fatty acids do not have any specific effects on known haemostatic risk markers for cardiovascular disease in healthy young men in the short-term.

Keywords

LipidsFibrinolysisCoagulationTrans fatty acids
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue 6 , June 2003 , pp. 767 - 776
Copyright
Copyright © The Nutrition Society 2003

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