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Growth hormone in infant malnutrition: the arginine test in marasmus and kwashiorkor

Published online by Cambridge University Press:  19 January 2009

F. Beas ,
I. Contreras ,
A. Maccioni  and
Sara Arenas
F. Beas
Affiliation:
Department of Pediatrics, Laboratory for Pediatric Research, University of Chile
I. Contreras
Affiliation:
Department of Pediatrics, Laboratory for Pediatric Research, University of Chile
A. Maccioni
Affiliation:
Department of Pediatrics, Laboratory for Pediatric Research, University of Chile
Sara Arenas
Affiliation:
Department of Pediatrics, Laboratory for Pediatric Research, University of Chile
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Abstract

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1. Experiments in children and in animals seem to demonstrate that in marasmic malnutrition there is a reduction in the secretion of growth hormone. To study this problem the fasting, resting plasma concentrations of growth hormone were determined, before, and 45 and 60 min after, stimulation with an intravenous dose of arginine, in six infants with marasmus, in six infants with kwashiorkor and in five normal infants.

2. The values of plasma growth hormone (4·5 ± 0·97 ng/ml) in marasmic infants were significantly (P < 0·001) lower than those of the controls (7·8 ± 2·6 ng/ml), and responded little to stimulation with arginine (5·1 and 5·8 ng/ml at 45 and 60 min respectively), in contrast to those in the control group, which rose to 16·4 and 14·6 ng/ml. In children with kwashiorkor the values were very variable, but generally high, and showed little response (25·6 ± 13·3 before and 25·0 ± 17·6 and 14·2 ± 5·3 ng/ml at 45 and 60 min after stimulation respectively).

3. These results demonstrate that the responses of the hypophysis to deprivation of calories and protein (marasmus) and to protein deprivation (kwashiorkor) are different: in marasmus there is a progressive adaptation, with low secretion and poor reaction to stimulation, whereas in kwashiorkor the process is acute with high basal values of plasma growth hormone.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 26 , Issue 2 , September 1971 , pp. 169 - 175
Copyright
Copyright © The Nutrition Society 1971

References

REFERENCES

Alleyne, G. A. O. & Young, V. H. (1966). Lancet i, 911.CrossRefGoogle Scholar
Beas, F. (1970). Revta chil. Pediat. 41, 277.Google Scholar
Beas, F., Monckeberg, F., Horwitz, I. & Figueroa, M. (1966). Pediatrics, N.Y. 38, 1003.Google Scholar
Biag, E. & Edozien, J. (1965). Lancet ii, 662.CrossRefGoogle Scholar
Brusner, O., Reid, A., Monckeberg, F., Maccioni, A. & Contreras, I. (1968). Am. J. clin. Nutr. 21, 976.Google Scholar
Conte, F. A., Kaplan, S. L., Abrams, C. A. L. & Grumbach, M. M. (1966). J. Pediat. 69, 969.CrossRefGoogle Scholar
Donso, G., Undurraga, O., Weshler, A., Barja, I. & Saez, M. (1962). Pediatria, Santiago 5, 135.Google Scholar
Glick, S. M., Roth, K., Yalow, R. S. & Berson, S. A. (1965). Recent Prog. Horm. Res. 21, 241.Google Scholar
Hunter, W. M., Fonseka, C. C. & Passmore, R. (1965). Q. Jl. exp. Physiol. 50, 406.CrossRefGoogle Scholar
Hunter, W. M. & Greenwood, F. C. (1964). Biochem. J. 91, 43.CrossRefGoogle Scholar
Kaplan, S. L., Abrams, C. A. L., Bell, J. J., Conte, F. A. & Grumbach, M. M. (1968). Pediat Res. 2, 43.CrossRefGoogle Scholar
Knopf, R. T., Conn, J. N., Fajans, S. S., Floyd, J. C., Guntsche, E. M. & Rull, J. A. (1965). J. clin. Endocr. Metab. 25, 1140.CrossRefGoogle Scholar
Landen, J. & Greenwood, F. C. (1968). Proc. int. Congr. Endocr. III. Mexico, D.F. p. 595.Google Scholar
Landen, J., Greenwood, F. C., Stamp, T. C. & Wynn, V. V. (1966). J. clin. Invest. 45, 437.CrossRefGoogle Scholar
Leblond, C. P. & Carriere, R. (1955). Endocrinology 56, 261.CrossRefGoogle Scholar
Marks, V., Howarth, N. & Greenwood, F. C. (1965). Nature, Lond. 208, 686.CrossRefGoogle Scholar
Merimee, T. J., Riggs, L., Rimoin, D. L., Rabinowitz, D., Burgess, J. A. & McKusic, V. A. (1967). New Engl. J. Med. 276, 434.CrossRefGoogle Scholar
Monckeberg, F., Donso, G., Oxman, S., Pak, N. & Meneghello, J. (1963). J. Pediat. 31, 58.CrossRefGoogle Scholar
Morgan, C. R. (1966). Proc. Soc. exp. Biol. Med. 121, 62.CrossRefGoogle Scholar
Muzzo, S. & Beas, F. (1967). VII Reun. An. Soc. Latinoamer. Invest. Pediat., Sao Paulo, Brasil p. 37.Google Scholar
Muzzo, S. & Beas, F. (1968). 1st Congr. Soc. Latinoamer. Nutr., Inst. Nac. Nutr., Caracas, Venezuela.Google Scholar
Muzzo, S., Egaña, E. & Beas, F. (1970). J. Pediat. 77, 717.Google Scholar
Oxman, S., Maccioni, A., Zuñiga, A., Spada, R. & Monckeberg, F. (1968). Am. J. clin. Nutr. 21, 1285.Google Scholar
Parker, M. L., Hammond, J. M., Daughaday, W. H. (1967). J. clin. Endocr. Metab. 27, 1129.CrossRefGoogle Scholar
Pimstone, B. L., Wittmann, W., Hansen, J. D. L. & Murray, P. (1966). Lancet ii, 779.CrossRefGoogle Scholar
Raiti, S., Davis, W. T. & Blizzard, R. M. (1967). Lancet ii, 1182.CrossRefGoogle Scholar
Roth, J., Glick, S. M., Yalow, R. S. & Berson, S. A. (1963 a). Metabolism 12, 577.Google Scholar
Roth, J., Glick, S. M., Yalow, R. S. & Berson, S. A. (1963 b). Science, N.Y. 140, 987.CrossRefGoogle Scholar
Salinas, A. & Colombo, M. (1968). VIII Reun. An. Soc. Latinoamer. Invest. Ped., Lima, Perú p. 38.Google Scholar
Tejada, C. & Russfield, A., (1957). Archs Dis. Childh. 32, 343.CrossRefGoogle Scholar