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Glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats

Published online by Cambridge University Press:  09 March 2007

C. Suberville ,
P. Higueret ,
D. Taruoura ,
H. Garcin  and
D. Higueret
C. Suberville
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
P. Higueret
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
D. Taruoura
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
H. Garcin
Affiliation:
Laboratoire Physiologie de la Nutrition, Département Alimentation et Nutrition, Université de Bordeaux I, avenue des Facultés, 33405 Talence-Cédex, France
D. Higueret
Affiliation:
Laboratoire Biochimie Médicale, Hôpital Pellegrin, Place Raba Léon, 33000 Bordeaux, France
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Abstract

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1. For a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1·93 g cysteine/kg.

2. The thyroxine (T4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. Moreover, the extrathyroidal T4 pool and T4 disposal rate decreased.

3. Cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (T3). The T3 distribution space, extrathyroidal pool of T3 and T3 disposal rate were diminished.

4. In vitro, deiodination of T4 in liver homogenate assayed with endogenous glutathione (GSH) demonstrated decreased T3 production rates in the case of cysteine deficiency. This difference was minimized by the addition of GSH in amounts sufficient to saturate the reaction kinetics. In the light of this finding, GSH is probably involved in the promotion of certain thyroidal problems induced by a cysteine-deficient diet.

Type
Research Article
Information
British Journal of Nutrition , Volume 59 , Issue 3 , May 1988 , pp. 451 - 456
Copyright
Copyright © The Nutrition Society 1988

References

Abrams, G. M. & Larsen, P. R. (1973). Journal of Clinical Investigation 52, 2522–2531.Google Scholar
Balsam, A., Eisenstein, Z., Sexton, F. & Ingbar, S. H. (1978). Endocrinology 102, 1247–1253.CrossRefGoogle Scholar
Balsam, A. & Ingbar, S. H. (1978). Clinical Research 26, 489A.Google Scholar
Bradford, M. (1976). Analytical Biochemistry 72, 248–254.CrossRefGoogle Scholar
Cheng, S. Y. (1983). Endocrinology 112, 1754–1762.Google Scholar
Cho, E. S., Johnson, N. & Snider, B. C. F. (1984). Journal of Nutrition 114, 1853–1862.Google Scholar
Chopra, I. J. (1978). Science 199, 904–906.Google Scholar
Chopra, I. J., Chua Teco, G. N., Eisenberg, J. B., Wiersinga, W. M. & Solomon, D. H. (1982). Endocrinology 110, 163–168.Google Scholar
Chopra, I. J., Ho, R. S. & Lan, R. (1972). Journal of Laboratory and Clinical Medicine 80, 729–739.Google Scholar
Chopra, I. J., Solomon, D. H., Chopra, U., Wu, S. Y., Fisher, D. A. & Nakamura, Y. (1978). Recent Progress in Hormone Research 34, 521–567.Google Scholar
De Crombrugghe, B., Pitt Rivers, R. & Edelhoch, H. (1966). Journal of Biological Chemistry 241, 2766–2773.Google Scholar
De Groot, L. J. (1979). In Free Thyroid Hormones, pp. 632–635 [Ekins, R., Faglia, G., Pennisi, F. and Pinchera, A., editors]. Amsterdam, Oxford and Princeton: Excerpta Medica.Google Scholar
Di Lauro, R., Obici, S., Condliffe, D., Ursini, V. M., Musti, A., Moscatelli, C. & Avvedimento, V. E. (1984). European Journal of Biochemistry 148, 7–11.CrossRefGoogle Scholar
Geloso, J. P. & Bernard, G. (1967). Acta Endocrinologica 56, 561–566.Google Scholar
Glazenburg, E. J., Jeckel-Halsema, I. M. C., Scholtens, E., Baars, A. J. & Mulder, G. J. (1983). Journal of Nutrition 113, 1363–1373.Google Scholar
Griffith, O. W. (1980). Analytical Biochemistry 106, 207–212.Google Scholar
Hearn, M. T. W., Hancock, W. S. & Bishop, C. A. (1978). Journal of Chromatography 157, 337–343.Google Scholar
Higueret, P. & Garcin, H. (1982). Annals of Nutrition and Metabolism 26, 191–200.Google Scholar
Higueret, P. & Garcin, H. (1984). Annales d'Endocrinologie 45, 149–150.Google Scholar
Imai, Y., Kataoka, N. & Nishikimi, M. (1980). Endocrinologia Japonica 27, 201–207.CrossRefGoogle Scholar
Ingenbleek, Y. & Malvaux, P. (1980). American Journal of Clinical Nutrition 33, 609–616.Google Scholar
Jordan, D., Rousset, B., Perrin, F., Fournier, M. & Orgiazzi, J. (1980). Endocrinology 107, 1245–1248.Google Scholar
Köhrle, G., Brabant, R. & Hesh, D. (1987). Hormone Research 26, 58–78.Google Scholar
Lejeune, P. J., Marriq, C., Rolland, M. & Lissitky, S. (1983). Biochemical and Biophysical Research Communications 114, 73–80.CrossRefGoogle Scholar
Murphy, B. P. & Jachan, C. (1965). Journal of Laboratory and Clinical Medicine 66, 161–167.Google Scholar
Rao, S. G., Eckel, J., Rao, M. L. & Brever, M. (1976). Biochemical and Biophysical Research Communications 73, 98–104.Google Scholar
Rawitch, A. B., Litwer, M. R., Gregg, J., Turner, C. D., Rouse, J. B. & Hamilton, Y. W. (1984). Biochemical and Biophysical Research Communications 118, 423–428.Google Scholar
Scammel, J. G., Shiverick, K. T. & Fregly, M. J. (1986). Pharmacology 33, 52–57.Google Scholar
Sies, H. & Wendel, A. (1978). Functions of Glutathione in Liver and Kidney. Berlin, Heidelberg and New York: Springer-Verlag.Google Scholar
Sowers, J. E., Stockland, W. L. & Meade, R. J. (1972). Journal of Animal Science 35, 782–788.Google Scholar
Suberville, C., Higueret, P., Taruoura, D., Higueret, D. & Garcin, H. (1987). British Journal of Nutrition 58, 105–111.Google Scholar
Tateishi, N., Higashi, T., Naruse, A., Hikita, K. & Sakamoto, Y. (1981). Journal of Biochemistry 90, 1603–1610.CrossRefGoogle Scholar
Tietze, F. (1969). Analytical Biochemistry 27, 502–522.Google Scholar
Vigouroux, E. (1972). Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences, Paris 275, 579–582.Google Scholar
Visser, T. J., Van der Does-Tobe, T., Docter, R. & Henneman, G. (1976). Biochemical Journal 157, 479–482.Google Scholar