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Glucose turnover and recycling in unrestrained and unanesthetized 48-h-old fasting or post-absorptive newborn pigs

Published online by Cambridge University Press:  09 March 2007

Jean-Paul Pégorier ,
Pierre-Henri Duée ,
Carlo Simoes Nunes ,
Jean Peret  and
J. Girard
Jean-Paul Pégorier
Affiliation:
Centre de Recherches sur la Nutrition du CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France
Pierre-Henri Duée
Affiliation:
Centre de Recherches sur la Nutrition du CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France
Carlo Simoes Nunes
Affiliation:
Laboratoire de Physiologie de la Nutrition de PINRA, CNRZ, 78350 Jouy-en-Josas, France
Jean Peret
Affiliation:
Centre de Recherches sur la Nutrition du CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France
J. Girard
Affiliation:
Centre de Recherches sur la Nutrition du CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France
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Abstract

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1. The metabolism of glucose has been studied in 48-h-old unanesthetized fasting and post-absorptive sucking piglets.

2. Both [6-3H]- and [U-14CJglucose were administered either by a single injection method or by a primed infusion technique. The rates of glucose turnover and recycling were estimated under steady-state conditions.

3. The rates of glucose turnover and recycling in 48-h-old fasting or post-absorptive piglets were not statistically different when measured using the single injection technique or the printed infusion method.

4. The mean (with SE) rate of glucose turnover was 65.8 (2.5) in post-absorptive and 31.1 (1–9), μ mol/kg per min in fasted newborn pigs. Glucose utilization was linearly related to blood glucose concentration; regression analysis indicated a y-intercept of 7.2, μ mol/kg per min.

5. As tested by arterio-portal differences the gut was not releasing glucose or galactose in 5 h-post-absorptive sucking newborn pigs. Thus, the higher rates of glucose turnover in post-absorptive newborn pigs compared with fasting ones suggest that hepatic glucose production is enhanced in post-ahsorptive sucking piglets.

6. The mean (with SE) rates of glucose recycling were four times higher in post-absorptive piglets than in tasting ones, i.e. 14.4 (1.6) and 3.7 (0.5)% of [6-3H] glucose turnover respectively. As liver glycogen was exhausted in 48-h-old sucking piglets, this suggests that hepatic glucose production results from gluconeogenesis.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 2 , September 1984 , pp. 277 - 287
Copyright
Copyright © The Nutrition Society 1984

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