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Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat

Published online by Cambridge University Press:  09 March 2007

Nicole M. de Rose ,
Michiel L. Bots ,
Els Siebelink ,
Evert Schouten  and
Martijin B. Katan
Nicole M. de Rose*
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, the Netherlands
Michiel L. Bots
Affiliation:
Julius Center for Patient Oriented Research, University Medical Center, Utrecht, the Netherlands
Els Siebelink
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, the Netherlands
Evert Schouten
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, the Netherlands
Martijin B. Katan
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, the Netherlands The Wageningen Center for Food Sciences, Wageningen, the Netherlands
*
*Corresponding author: Ms N. M. de Roos, fax +31 317 483342, email [email protected]
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Abstract

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Low-fat diets, in which carbohydrates replace some of the fat, decrease serum cholesterol. This decrease is due to decreases in LDL-cholesterol but in part to possibly harmful decreases in HDL-cholesterol. High-oil diets, in which oils rich in monounsaturated fat replace some of the saturated fat, decrease serum cholesterol mainly through LDL-cholesterol. We used these two diets to investigate whether a change in HDL-cholesterol would change flow-mediated vasodilation, a marker of endothelial function. We fed thirty-two healthy volunteers two controlled diets in a 2×3·5 weeks' randomised cross-over design to eliminate variation in changes due to differences between subjects. The low-fat diet contained 59·7 % energy (en%) as carbohydrates and 25·7 en% as fat (7·8 en% as monounsaturates); the oil-rich diet contained 37·8 en% as carbohydrates and 44·4 en% as fat (19·3 en% as monounsaturates). Average (SD) SERUM HDL-CHOLESTEROL AFTER THE LOW-FAT DIET WAS 0·21 (sd 0·12) mmol/l (8·1 mg/dl) lower than after the oil-rich diet. Serum triacylglycerols were 0·22 (sd 0·28) mmol/l (19·5 mg/dl) higher after the low-fat diet than after the oil-rich diet. Serum LDL and homocysteine concentrations remained stable. Flow-mediated vasodilation was 4·8 (SD 2·9) after the low-fat diet and 4·1 (SD 2·7) after the oil-rich diet (difference 0·7 %; 95 % CI -0·6, 1·9). Thus, although the low-fat diet produced a lower HDL-cholesterol than the high-oil diet, flow-mediated vasodilation, an early marker of cardiovascular disease, was not impaired.

Keywords

LipoproteinsCardiovascular diseaseDiet
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 2 , August 2001 , pp. 181 - 188
Copyright
Copyright © The Nutrition Society 2001

References

Anonymous (1996) Nederlands Voedingsstoffenbestand, Den Haag: Voorlichtingsbureau voor de Voeding.Google Scholar
Anderson, TJ, Meredith, IT, Yeung, AC, Frei, B, Selwyn, AP & Ganz, P (1995) The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. New England Journal of Medicine 332, 488–493.CrossRefGoogle Scholar
Aro, A, Jauhiainen, M, Partanen, R, Salminen, I & Mutanen, M (1997) Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. American Journal of Clinical Nutrition 65, 1419–1426.CrossRefGoogle ScholarPubMed
Ashton, EL, Pomeroy, S, Foster, JE, Kaye, RS, Nestel, PJ & Ball, M (2000) Diet high in monounsaturated fat does not have a different effect on arterial elasticity than a low-fat, high-carbohydrate diet. Journal of the American Diet Association 100, 537–542.Google Scholar
Ballantyne, CM, Herd, JA, Ferlic, LL, Dunn, JK, Farmer, JA, Jones, PH, Schein, JR & Gotto, AMJ (1999) Influence of low HDL on progression of coronary artery disease and response to fluvastatin therapy. Circulation 99, 736–743.Google Scholar
Bellamy, MF, McDowell, IF, Ramsey, MW, Brownlee, M, Newcombe, RG & Lewis, MJ (1999) Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. European Journal of Clinical Nutrition 29, 659–662.Google ScholarPubMed
Berglund, L, Oliver, EH, Fontanez, N, Holleran, S, Matthews, K, Ginsberg, HN, Ramakrishnan, R & Lefevre, M (1999) HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects. American Journal of Clinical Nutrition 70, 992–1000.Google Scholar
Bray, GA & Popkin, BM (1998) Dietary fat intake does affect obesity!. American Journal of Clinical Nutrition 68, 1157–1173.Google Scholar
Brouwer, IA, van Dusseldorp, M, West, CE, Meyboom, S, Thomas, CM, Duran, M, van het, H, Eskes, TK, Hautvast, JG & Steegers-Theunissen, RP (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. Journal of Nutrition 129, 1135–1139.CrossRefGoogle Scholar
Castelli, WP, Anderson, K, Wilson, PW & Levy, D (1992) Lipids and risk of coronary heart disease. The Framingham Study. Annals of Epidemiology 2, 23–28.Google Scholar
Celermajer, DS, Adams, MR, Clarkson, P, Robinson, J, McCredie, R, Donald, A & Deanfield, JE (1996) Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. New England Journal of Medicine 334, 150–154.Google Scholar
Chambers, JC, McGregor, A, Jean-Marie, J, Obeid, OA & Kooner, JS (1999) Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia, an effect reversible with vitamin C. Circulation 99, 1156–1160.CrossRefGoogle ScholarPubMed
Clarke, R, Frost, C, Collins, R, Appleby, P & Peto, R (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. British Medical Journal 314, 112–117.Google Scholar
Clarkson, P, Celermajer, DS, Powe, AJ, Donald, AE, Henry, RM & Deanfield, JE (1997) Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. Circulation 96, 3378–3383.CrossRefGoogle ScholarPubMed
Connor, WE & Connor, SL (1997) The case for a low-fat, high-carbohydrate diet. New England Journal of Medicine 337, 562–563.Google ScholarPubMed
de Backer, G, de Bacquer, D & Kornitzer, M (1998) Epidemiological aspects of high density lipoprotein cholesterol. Atherosclerosis 137, S1–S6.Google Scholar
de Roos, NM, Schouten, EG & Katan, MB (2001) Consumption of a solid fat rich in lauric acid results in a more favourable serum lipid profile in healthy men and women than consumption of a solid fat rich in trans fatty acids. Journal of Nutrition 131, 242–245.Google Scholar
Duffy, SJ, Gokce, N, Holbrook, M, Huang, A, Frei, B, Keaney, JF & Vita, JA (1999) Treatment of hypertension with ascorbic acid. Lancet 354, 2048–2049.Google Scholar
Dupuis, J, Tardif, JC, Cernacek, P & Theroux, P (1999) Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial. Circulation 99, 3227–3233.Google Scholar
Gokce, N, Keaney, JFJ, Frei, B, Holbrook, M, Olesiak, M, Zachariah, BJ, Leeuwenburgh, C, Heinecke, JW & Vita, JA (1999) Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 99, 3234–3240.CrossRefGoogle ScholarPubMed
Goodman, SN (1999) Toward evidence-based medical statistics. 2: The Bayes factor. Annals of Internal Medicine 130, 1005–1013.Google Scholar
Gordon, DJ, Knoke, J, Probstfield, JL, Superko, R & Tyroler, HA (1986) High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial. Circulation 74, 1217–1225.CrossRefGoogle ScholarPubMed
Gordon, DJ, Probstfield, JL, Garrison, RJ, Neaton, JD, Castelli, WP, Knoke, JD, Jacobs, DRJ, Bangdiwala, S & Tyroler, HA (1989) High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 79, 8–15.CrossRefGoogle ScholarPubMed
Hulshof, KFAM, van Erp-Baart, MA & Anntolainen, M (1999) Intake of fatty acids in Western-Europe with emphasis on trans fatty acids: The Transfair Study. European Journal of Clinical Nutrition 53, 143–157.CrossRefGoogle ScholarPubMed
Huttunen, JK, Manninen, V, Manttari, M, Koskinen, P, Romo, M, Tenkanen, L, Heinonen, OP & Frick, MH (1991) The Helsinki Heart Study: central findings and clinical implications. Annals of Medicine 23, 155–159.Google Scholar
Jensen-Urstad, K & Rosfors, S (1997) A methodological study of arterial wall function using ultrasound technique. Clinical Physiology 17, 557–567.Google Scholar
Joannides, R, Haefeli, WE, Linder, L, Richard, V, Bakkali, EH, Thuillez, C & Luscher, TF (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91, 1314–1319.Google Scholar
Katan, MB, Grundy, SM & Willett, WC (1997) Beyond low-fat diets. New England Journal of Medicine 337, 563–566.Google ScholarPubMed
Kitamura, A, Iso, H, Naito, Y, Iida, M, Konishi, M, Folsom, AR, Sato, S, Kiyama, M, Nakamura, M, Sankai, T, Shimamoto, T & Komachi, Y (1994) High-density lipoprotein cholesterol and premature coronary heart disease in urban Japanese men. Circulation 89, 2533–2539.Google Scholar
Kuhn, FE, Mohler, ER, Satler, LF, Reagan, K, Lu, DY & Rackley, CE (1991) Effects of high-density lipoprotein on acetylcholine-induced coronary vasoreactivity. American Journal of Cardiology 68, 1425–1430.Google Scholar
Leung, WH, Lau, CP & Wong, CK (1993) Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients. Lancet 341, 1496–1500.Google Scholar
Lichtenstein, AH, Ausman, LM, Jalbert, SM & Schaefer, EJ (1999) Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. New England Journal of Medicine 340, 1933–1940.Google Scholar
Lundman, P, Eriksson, M, Schenck-Gustafsson, K, Karpe, F & Tornvall, P (1997) Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease. Circulation 96, 3266–3268.Google Scholar
Mensink, RP & Katan, MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arteriosclerosis and Thrombosis 12, 911–919.Google Scholar
Miller, M, Teter, B, Dolinar, C & Georgopoulos, A (1998) An NCEP II diet reduces postprandial triacylglycerol in normocholesterolemic adults. Journal of Nutrition 128, 582–586.CrossRefGoogle ScholarPubMed
Müller, H, Jordal, O, Kierulf, P, Kirkhus, B & Pedersen, JI (1998) Replacement of partially hydrogenated soybean oil by palm oil in margarine without unfavorable effects on serum lipoproteins. Lipids 33, 879–887.CrossRefGoogle ScholarPubMed
Nestel, PJ, Pomeroy, SE, Sasahara, T, Yamashita, T, Liang, YL, Dart, AM, Jennings, GL, Abbey, M & Cameron, JD (1997) Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arteriosclerosis, Thrombosis and Vascular Biology 17, 1163–1170.CrossRefGoogle ScholarPubMed
Neunteufl, T, Heher, S, Katzenschlager, R, Wslfl, G, Maurer, G & Weidinger, F (1999) Long-term prognostic value of low-mediated vasodilation in the brachial artery of patients with angina pectoric: results of a 5-year follow-up study. Circulation 100, 1–48(Abstract).Google Scholar
Neunteufl, T, Priglinger, U, Heher, S, Zehetgruber, M, Soregi, G, Lehr, S, Huber, K, Maurer, G, Weidinger, F & Kostner, K (2000) Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. Journal of the American College of Cardiology 35, 277–283.Google Scholar
apos;Brien, SF, Watts, GF, Playford, DA, Burke, V, O'Neal, DN & Best, JD (1997) Low-density lipoprotein size, high-density lipoprotein concentration, and endothelial dysfunction in non-insulin-dependent diabetes. Diabetic Medicine 14, 974–978.Google Scholar
O'Driscoll, G, Green, D & Taylor, RR (1997) Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 95, 1126–1131.CrossRefGoogle ScholarPubMed
Ong, PJ, Dean, TS, Hayward, CS, Della, MP, Sanders, TA & Collins, P (1999) Effect of fat and carbohydrate consumption on endothelial function. Lancet 354, 2134.Google Scholar
Pearson, TA, Bulkley, BH, Achuff, SC, Kwiterovich, PO & Gordis, L (1979) The association of low levels of HDL cholesterol and arteriographically defined coronary artery disease. American Journal of Epidemiology 109, 285–295.CrossRefGoogle ScholarPubMed
Plotnick, GD, Corretti, MC & Vogel, RA (1997) Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA 278, 1682–1686.CrossRefGoogle ScholarPubMed
Schaefer, EJ, Lichtenstein, AH, Lamon-Fava, S, Contois, JH, Li, Z, Rasmussen, H, McNamara, JR & Ordovas, JM (1995) Efficacy of a National Cholesterol Education Program Step 2 diet in normolipidemic and hypercholesterolemic middle-aged and elderly men and women. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 1079–1085.CrossRefGoogle ScholarPubMed
Schnell, GB, Robertson, A, Houston, D, Malley, L & Anderson, TJ (1999) Impaired brachial artery endothelial function is not predicted by elevated triglycerides. Journal of the American College of Cardiology 33, 2038–2043.Google Scholar
Schorah, CJ, Devitt, H, Lucock, M & Dowell, AC (1998) The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study. European Journal of Clinical Nutrition 52, 407–411.Google Scholar
Sharrett, AR, Sorlie, PD, Chambless, LE, Folsom, AR, Hutchinson, RG, Heiss, G & Szklo, M (1999) Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence. American Journal of Epidemiology 149, 843–852.CrossRefGoogle ScholarPubMed
Simons, LA, Sullivan, D, Simons, J & Celermajer, DS (1998) Effects of atorvastatin monotherapy and simvastatin plus cholestyramine on arterial endothelial function in patients with severe primary hypercholesterolaemia. Atherosclerosis 137, 197–203.Google Scholar
Sorensen, KE, Celermajer, DS, Spiegelhalter, DJ, Georgakopoulos, D, Robinson, J, Thomas, O & Deanfield, JE (1995) Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. British Heart Journal 74, 247–253.Google Scholar
Sorlie, PD, Sharrett, AR, Patsch, W, Schreiner, PJ, Davis, CE, Heiss, G & Hutchinson, R (1999) The relationship between lipids/lipoproteins and atherosclerosis in African Americans and whites: the Atherosclerosis Risk in Communities Study. Annals of Epidemiology 9, 149–158.CrossRefGoogle ScholarPubMed
Tawakol, A, Omland, T, Gerhard, M, Wu, JT & Creager, MA (1997) Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 95, 1119–1121.Google Scholar
Toikka, JO, Ahotupa, M, Viikari, JS, Niinikoski, H, Taskinen, M, Irjala, K, Hartiala, JJ & Raitakari, OT (1999) Constantly low HDL-cholesterol concentration relates to endothelial dysfunction and increased in vivo LDL-oxidation in healthy young men. Atherosclerosis 147, 133–138.Google Scholar
Treasure, CB, Klein, JL, Weintraub, WS, Talley, JD, Stillabower, ME, Kosinski, AS, Zhang, J, Boccuzzi, SJ, Cedarholm, JC & Alexander, RW (1995) Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. New England Journal of Medicine 332, 481–487.Google Scholar
Turley, ML, Skeaff, CM, Mann, JI & Cox, B (1998) The effect of a low-fat, high-carbohydrate diet on serum high density lipoprotein cholesterol and triglyceride. European Journal of Clinical Nutrition 52, 728–732.CrossRefGoogle ScholarPubMed
Ubbink, JB, Hayward Vermaak, WJ & Bissbort, S (1991) Rapid high-performance liquid chromatography assay for total homo-cysteine levels in human serum. Journal of Chromatography 565, 441–446.Google Scholar
Ueland, PM, Refsum, H, Stabler, SP, Malinow, R, Andersson, A & Allen, RH (1993) Total homocysteine in plasma or serum: methods and clinical applications. Clinical Chemistry 39, 1764–1779.Google Scholar
Vogel, RA, Corretti, MC & Plotnick, GD (1996a) Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. American Journal of Cardiology 77, 37–40.Google Scholar
Vogel, RA, Corretti, MC & Plotnick, GD (1997b) Effect of a single high-fat meal on endothelial function in healthy subjects. American Journal of Cardiology 79, 350–354.CrossRefGoogle ScholarPubMed
Walden, CE, Retzlaff, BM, Buck, BL, Wallick, S, McCann, BS & Knopp, RH (2000) Differential effect of National Cholesterol Education Program (NCEP) Step II diet on HDL cholesterol, its subfractions, & apoprotein A-I levels in hypercholesterolemic women and men after 1 year: the beFIT Study. Arteriosclerosis, Thrombosis and Vascular Biology 20, 1580–1587.Google Scholar
Williams, MJA, Sutherland, WHF, McCormick, MP, de Jong, SA, Walker, RJ & Wilkins, GT (1999) Impaired endothelial function following a meal rich in used cooking fat. Journal of the American College of Cardiology 33, 1050–1055.Google Scholar
Wilmink, HW, Stroes, ES, Erkelens, WD, Gerritsen, WB, Wever, R, Banga, JD & Rabelink, TJ (2000) Influence of folic acid on postprandial endothelial dysfunction. Arteriosclerosis, Thrombosis Vascular Biology 20, 185–188.Google Scholar
Zeiher, AM, Schachlinger, V, Hohnloser, SH, Saurbier, B & Just, H (1994) Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 89, 2525–2532.CrossRefGoogle ScholarPubMed
Zhang, X, Zhao, SP, Li, XP, Gao, M & Zhou, QC (2000) Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease. Atherosclerosis 149, 19–24.Google Scholar