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Factors influencing the composition of the weight lost by obese patients on a reducing diet

Published online by Cambridge University Press:  09 March 2007

Merril L. Durrant ,
J. S. Garrow ,
P. Royston ,
Susan F. Stalley ,
Shirley Sunkin  and
Penelope M. Warwick
Merril L. Durrant
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
J. S. Garrow
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
P. Royston
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Susan F. Stalley
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Shirley Sunkin
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Penelope M. Warwick
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
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Abstract

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1.Weight loss, resting metabolic rate and nitrogen loss were measured in forty obese inpatients on reducing diets.

2. Five subjects ate 3·55 MJ/d for 6 weeks (Expt I). Twenty-one subjects ate 4.2 MJ/d for the first week, 2·0 MJ/d for the second week and 4 2 MJ/d for the third week (Expt 2). Fourteen subjects ate 3·4 MJ/d for the first week and then 0.87 MJ protein or carbohydrate for the second or third weeks, using a cross-over design for alternate patients (Expt 3).

3. Patients in Expt I had highest weight loss and N loss in the first 2 weeks, but adapted to the energy restriction over the remaining weeks. On average subjects were in N balance at the end of the study.

4. In Expt 2 patients eating 2·0 MJ/d in week 2 showed increased weight loss compared with week I.N loss was not raised but it failed to decrease as it had in Expt I. Weight loss and N loss were reduced on return to 4.2 MJ/d for a third week.

5. In Expt 3 patients eating 0·87 MJ protein showed significantly more weight loss and less N loss than patients eating 0·87 MJ carbohydrate.

6. Resting metabolic rate decreased with time on the low-energy diet, but the manipulations of energy or protein content did not significantly affect the pattern of decrease.

7. Both weight loss and N loss were greater the lower the energy intake, and both decreased with time. Diets with a high protein:energy value give a favourable value for N:weight loss at each level of energy intake.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 3 , November 1980 , pp. 275 - 285
Copyright
Copyright © The Nutrition Society 1980

References

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