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Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants

Published online by Cambridge University Press:  08 March 2007

Mary R. Sweeney ,
Joseph McPartlin ,
Donald G. Weir ,
Sean Daly ,
Kristina Pentieva ,
Leslie Daly  and
John M. Scott
Mary R. Sweeney*
Affiliation:
Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland Department of Public Health Medicine and Epidemiology, University College Dublin, Earlsfort Terrace, Dublin 2, Ireland
Joseph McPartlin
Affiliation:
Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland
Donald G. Weir
Affiliation:
Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland
Sean Daly
Affiliation:
Coombe Woman's Hospital, Dublin, Ireland
Kristina Pentieva
Affiliation:
Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine BT52 ISA, Northern Ireland
Leslie Daly
Affiliation:
Department of Public Health Medicine and Epidemiology, University College Dublin, Earlsfort Terrace, Dublin 2, Ireland
John M. Scott
Affiliation:
Department of Biochemistry, University of Dublin, Trinity College, Dublin, Ireland
*
*Corresponding author: Dr Mary R. Sweeney, fax +353 1 7167407, email [email protected]
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Abstract

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Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia; more recently the theoretical potential for high-dose folic acid to promote cancer has been highlighted. In this paper we set out to examine the appearance of unmetabolised folic acid both in cord blood from newborn full-term and premature infants and serum from 4-d-old infants post-formula feeding. Blood was collected from the umbilical cord of eleven infants in the delivery room immediately after birth. A follow-up serum sample (n 9) was collected 4d later from infants post-formula feeding. We detected unmetabolised folic acid in cord blood from all infants at birth. In addition, unmetabolised folic acid was present in serum of seven infants post-formula feeding, six of which had increased from birth. Our results imply that infants in Ireland, which does not yet have mandatory fortification, could potentially have circulatory unmetabolised folic acid at the time of birth. We do not know if the presence of folic acid in cord blood will have any adverse consequences. However, if theoretical safety concerns are borne out by future research, the likelihood is that the longer the exposure the more likely the potential for harm. This would also be the case in infants exposed to unmetabolised folic acid as a result of formula feeding.

Keywords

Folic acidCord bloodInfantsIrelandCirculatory unmetabolised folic acidInfant formula
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 727 - 730
Copyright
Copyright © The Nutrition Society 2005

References

Achon, M, Reyes, Leticia, Alonso-Aperte, E, Ubeda, N & Varela-Moreiras, G (1999) High dietary folate supplementation affects gestational development and dietary protein utilisation in rats. Am Soc Nutr Sci 129, 1204–1209.Google ScholarPubMed
Berger, H (1998) Significance of cord blood values for the newborn. In Vitamins and Minerals in Pregnancy and Lactation. Workshop Series no. 16, Nestle Nutrition [Berger, H, editor]. New York: Raven Press.Google Scholar
Chanarin, I, Laidlow, J, Loughridge, LW & Mollin, DL (1960) Megaloblastic anaemia due to phenobarbitone. The convulsant action of therapeutic doses of folic acid. Br Med J 1, 1099.CrossRefGoogle ScholarPubMed
Charles, D, Ness, AR, Campbell, D, Smith, GD & Hall, MH (2004) Taking folate in pregnancy and risk of maternal cancer. Br Med J 329, 1375–1376.CrossRefGoogle Scholar
Committee on Medical Aspects of Food and Nutrition Policy (COMA) (2000) Folic Acid and the Prevention of Disease. London: The Stationery Office.Google Scholar
Food Safety Authority of Ireland (2003) Risk Benefit Analysis of Fortification of Flour in the Republic of Ireland. Dublin: Food Safety Authority of Ireland Nutrition Sub-Committee, March.Google Scholar
Giovannucci, E, Stampfer, MJ, Colditz, GA, Hunter, DJ, Fuchs, C, Rosner, B, Speizer, FE & Willett, WC (1998) Multivitamin use, folate and colon cancer in women in the Nurses’ Health Study. Ann Intern Med 129, 517–524.CrossRefGoogle ScholarPubMed
Hibbard, ED & Smithells, RW (1965) Folic acid metabolism and human embryopathy. Lancet I, 1254–1256.CrossRefGoogle Scholar
Johan, EK & Magnus, E (1980) Plasma and red cell folacin in cow's milk-fed infants and children during the first 2 years of life, the significance of boiling pasteurised cow's milk. Am J Clin Nutr 33, 1220–1224.Google Scholar
Kelly, P, McPartlin, J, Goggins, M, Weir, DG & Scott, JM (1997) Unmetabolised folic acid in sera: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 65, 1790–1795.CrossRefGoogle Scholar
Kim, Y-I (2004) Will mandatory folic acid fortification prevent or promote cancer. Am J Clin Nutr 80, 1123–1128.CrossRefGoogle ScholarPubMed
Lucock, M, Wild, J, Smithells, R & Hartley, R (1989) Biotransformation of pteroyl monoglutamic acid during absorption: implications of Michaelis–Menton Kinetics.. Eur J Clin Nutr 43, 631–5.Google Scholar
Lucock, M & Yates, Z (2005) Folic acid – vitamin and panacea or genetic time bomb? Nat Rev Genet 6, 235–240.CrossRefGoogle ScholarPubMed
Molloy, A & Scott, JM (1997) Microbiological assay for serum, plasma and red cell folate using cryopreserved microtitre plate method. Methods Enzymol 281, 43–53.CrossRefGoogle Scholar
Quinlivan, EP & Gregory, JF (2003) Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 77, 221–225.CrossRefGoogle ScholarPubMed
Sweeney, MR, McPartlin, J, Weir, DG & Scott, JM (2003) Measurements of subnanomolar concentrations of unmetabolised folic acid in serum. J Chromotogr B 788, 187–191.CrossRefGoogle ScholarPubMed
Tamura, T (1998) Determination of food folates. Nutr Biochem 9, 285–293.CrossRefGoogle Scholar
Thompson, JR, Fitzgerald, P, Willoghby, ML & Amstrong, BK (2001) Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 358, 1935–1940.CrossRefGoogle ScholarPubMed
Weir, DG & Scott, JM (1998) Vitamin B12: cobalamin. In Modern Nutrition in Health and Disease, 9th ed. pp. 447–458 [Shils, ME, Olsen, JA, Shike, M and Ross, AC, editors]. Baltimore, MD: Williams and Wilkins.Google Scholar