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Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats

Published online by Cambridge University Press:  08 March 2007

Keiichiro Sugimoto ,
Junko Suzuki ,
Kazuya Nakagawa ,
Shuichi Hayashi ,
Toshiki Enomoto ,
Tomoyuki Fujita ,
Ryoichi Yamaji ,
Hiroshi Inui  and
Yoshihisa Nakano
Keiichiro Sugimoto
Affiliation:
Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan Research and Development Center, Nagaoka Perfumery Co. Ltd, Ibaraki, Osaka 567-005, Japan
Junko Suzuki
Affiliation:
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
Kazuya Nakagawa
Affiliation:
Research and Development Center, Nagaoka Perfumery Co. Ltd, Ibaraki, Osaka 567-005, Japan
Shuichi Hayashi
Affiliation:
Research and Development Center, Nagaoka Perfumery Co. Ltd, Ibaraki, Osaka 567-005, Japan
Toshiki Enomoto
Affiliation:
Department of Food Science, Ishikawa Agricultural College, Nonoichi, Ishikawa 921-8836, Japan
Tomoyuki Fujita
Affiliation:
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
Ryoichi Yamaji
Affiliation:
Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
Hiroshi Inui*
Affiliation:
Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
Yoshihisa Nakano
Affiliation:
Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan
*
*Corresponding author: Dr Hiroshi Inui, fax +81 72 254 9937, email [email protected]
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Abstract

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Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75 % in calorie base) with or without ELE (10 g/kg diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (sd 37·9) v. 392 (sd 26·0) g (n 7); P<0·05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1·44 (sd 0·448) v. 2·79 (sd 0·677) mmol/l (n 7); P<0·05) and liver (19·1 (sd 5·07) v. 44·1 (sd 16·28) μmol/g (n 7); P<0·05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 min after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, which inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.

Keywords

AdiposityDietary sucroseIntestinal fructose absorptionEucalyptusEucalyptus globulus
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 6 , June 2005 , pp. 957 - 963
Copyright
Copyright © The Nutrition Society 2005

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